At2g13720.1/MSA

>gi|15225481|ref|NP_178993.1|	  223 residues, 50 /line  ATP binding / DNA binding / DNA topoisomerase (ATP-hydrolyzing) [Arabidopsis thaliana]

MWAL V-AQAERLG--SMRCRA---

--SRMPRGREWPRVRVPRDGLKS-SFITVLVT PYVKVSRL--TFSSHKYFIVLTNLSYVTSTLNTRNGKMKDRN--YLNRWTIKFYKG VWVQVMRE-KNVLSNVDQNKRFFIW-DEGSEAALENAFGTSE-DKQKKWIEKYVPGT--- -FL-DSKKQQIMYSDFVTKKLKLYFTTSNQRKHININKKNYILKKNDKKSKK IILKKYEKKVIQYIIIVLLI

--- >gi|10281012|dbj|BAB13747.1|	  777 residues, 50 /line  type II DNA topoisomerase [Kluyveromyces marxianus] -TDC MI---EKTVNIVPGLFKIFDEILVNAADNKVRD--P SMKKIDVTINQEENLIEVRNDGKGIPVEIHEKEG---IYIPEMIFGHLLTSSNYDDDEKK VTGGRNGYGAKVCNIFSTEFILETADPSKGQKYVQKWENNMSVCHPPSITSYKRGPSYTK VSFRADLQRFNMEKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKPLKIKNFKNYVELYLK SLEKIK-LNRLQELTNPDEPAQE---PTNIPAILYEKINDRWEI AFAVSENS-FQQISFVNSIATTSGGTHVNYVTDQIVKKVSDRLKKQKKS-IKPFQI KNNMF--IFINCLIENPAFTSQTKEQLTTRVKDFGSK--CE--VP-NDFVNK-VMKTDLA TRIFDIADENAEKQLKKTDGSRK-NRITEYPKLEDANKAGTKEGYKCTLVLTEGDS ALSLAVAGLAVVGRDYYGCFPLRGKMLNVRDATPDQITKNAEIQAIKKIMGLQHKKR-Y- --EDATSLRYGHITIMTDQDHDGS-HIKGLIINFLESSFPGL--LDIPGFLIEFIT PIIKITIT---RPKKQ-TISFYNMPDYEKWREEESHK-YTWKQKYYKG LGTSTQQEAREYFSQLDLHLKKFHALQGDDCQLIDLAFSKKKADDRKEWLKLYEPGT--- -VL-DPKLTEIPISDFINKELILFSLADNIRSIPSV--LDGLKPGQRK VIYACFKRNLKSEIKVAQLGGYVSEHTGYHHGEPSLYQTIVGLAQDFVGSNNIYLLKPNG AFGTRATGGKDSAAPRYIFTELNKITRKIFNSLDDPLLTYIQDDEQTVEPEW

--- >gi|1633273|pdb|1BGW|	  793 residues, 50 /line  Topoisomerase Residues 410 - 1202,

---ENALKKSDGTRK-SRITNYPKLEDANKAGTKEGYKCTLVLTEGDS ALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKK-Y- --EDTKSLRYGHLMIMTDQDHDGS-HIKGLIINFLESSFLGL--LDIQGFLLEFIT PIIKVSIT---KPTKN-TIAFYNMPDYEKWREEESHK-FTWKQKYYKG LGTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQYEPGT--- -VL-DPTLKEIPISDFINKELILFSLADNIRSIPNV--LDGFKPGQRK VLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNG AFGTRATGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMI LVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYR MYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDNIKFII TLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYY QKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPR-FNKEG KPYYGSPNDEIAEQINDVKG---ATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRI WSLTKERYQKLLKQKQEKETELENLLKLSAKDIWNTDLKAF---

---EVGYQEFLQRDAEARGGNVPNKGSKTKGKGKRKLVDD ED- >gi|10281014|dbj|BAB13748.1|	  804 residues, 50 /line  type II DNA topoisomerase [Issatchenkia orientalis] -LKC ME---KKTVSIVPGLFKIFDEILVNAADNKIRD--P SMKRIDVIINEEENVISVKNDGKGIPIEIHDKEN---IYIPELIFGNLLTSSNYDDDQKK VTGGRNGYGAKLCNIFSTEFTVHTADMSHGKEYTQVWRNNMSEVGKPKILNFKKKNEFTE IIFKPDLSKFGMEKLDHDILGVFKRRVYDLCGSVRGIRVTLNGELLKINNFKQYVELYVK AINKSKEERPHIPVKIETEDGTPLNGESEANTETSSTPEPSLNENLPTIVHEIINDRWEI AFCISDGS-FNQVSFVNSIATTLGGTHVDDVANMLCGKITEQIKRKNK---KAIIKPFQI KSKMF--LFINCLVENPAFTFQTKEYLTTQLSKFGGK---RLELP-EKFIKK-ILNTGII DEVLDIVQANADKALKKTDGAKK-SRITGYPKLEDANKAGTREGYKCTLILTEGDS AKSLAVQGLAVVGRNYYGCFPLRGKVLNVREASTDQIMKNGAIQAIKQIMGLQHKKH-Y- GPDDIKSLRYGRIMIMADQDHDGS-HIKGLLINFLEASFPGL--LEIPNFLIEFIT PIVKITIMS-GPNRRK-TIPFYSMPEYEQWRETEGST-CSYKQKYYKG LGTSSAQEMREYFTQLDKHLKRFDALRDEDKSSIDLAFSKKKADDRKEWLRNYQPGT--- -YL-DSTLSDIPISEFINKELILFSMADNVRSIASV--MDGFKPVQRK ILYACYKRNLRDEIKVSQLEGYIAEHTGYHHGDASLMQSIIGLAQDFVGSNNINLLVPHG GFGSRAAGGKDAAAARYIFTELSAITRKIFNPLDNPLLTYVQDDEQTVEPEW

--- >gi|10281026|dbj|BAB13754.1|	  782 residues, 50 /line  type II DNA topoisomerase [Pichia guilliermondii] -TES MI---YKEVHIVPGLYKIFDEILVNAADNKIRD--P SMRNIKVNIDAENNTILVMNDGKGIPIEIHKKEK---IYIPELIFGNLLTSSNYDDDEKK VTGGRNGYGAKLCNIFSTEFVLETADLNTSQVYKQTWTNNMANLTKPKITKLKSKKEYTK VTFKPDLSKFHMEMLDDDILSVLRRRVYDLCGTVKDCNIYLNDKKLSIRNFKSYVEMYVN AIRE---RSPD-PVAPEGE---TRNYSTIVHEVFNDRWEV AFAVSDGS-FNQVSFVNSIATTSGGTHVKYVSDQIITKLIDALTKKEKGKKKLNIKPQEV RNNMF--VFINCLIENPAFTSQTKEQLTTRVAQFGGKPLEKIVIS-DQFIAK-ILKTSIA DKIRTIVNANEDKEMLKADGSRK-SRIKNQVKLVDANKAGTKEGYKCTLILTEGDS AMPLAVAGLTVVGRDYYGCFPLRGKLLNVREASIEQVSKNAEINSIKQIMGLQHKKR-Y- TPENIKSLRYGHIMIMTDQDQDGS-HIKGLIINFLETSFPGL--LEIPGFLLEFIT PIVKVTIT--GRGNHR-VIPFYNMPEFEKWRETEGTT-CKWKHKYFKG LGTSLESEGREYFAALDRHMKSFHALQDGDSQYIDMAFSKKKADERKDWLQAFRPGT--- -HL-DPQIREIPISEFINKELILFSMADNVRSIPSI--LDGFKPGQRK VLYGCFKRNLRSEIKVAQLVGYISEHTGYHHGEGSLAQTIVGLAQNFVGANNLNLLQPIG LFGSRAAGGKDFSAVRYIHTNITDLTRVIFNPLDDDLYTYVQDDAQTVEPEA

--- >gi|10281028|dbj|BAB13755.1|	  772 residues, 50 /line  type II DNA topoisomerase [Clavispora lusitaniae] -SEK MV---QKSVKIVPGLYKIFDEILVNAADNKIRD--P SMKQLKVNIDVESNTITVRNDGRGIPVEIHEKEQ---MYIPEMIFGNLLTSSNYDDDEKK VTGGRNGYGAKLCNIFSTEFTVETADLSNGKVYQQVWTNNMSKCNPPKIKKMTAKREYTQ ITFKPDLAKFGMERLDDDIVSVMKRRVFDLCGTVRDCSVFLNDTKLPIKSFKQYVDMYVQ ALRQ---LDDS-D-DPKSSVVVHENFGDRWEV AFAVSDGS-FQQVSFVNSIATTSGGTHVKMLTDSIVKQLTESISAKRGKKKALMVKPQEV KNNMF--LFVNCLVENPAFTSQTKEQMTTKPAKFGSK---PV-IT-EDFIKKLIAKTSIT DKLHSLSQANEDKALARQDGSRR-SRVKS-AKLHDANKAGTKDGHKCTLILTEGDS ALAQAVVGLKVVGNEYYGCFPLRGKMLNVRDASADQISKNAEINEIKKIIGLQHKKH-Y- TPESLKSLRYGHILIMTDQDHDGS-HIKGLLINFFESSFPGL--LQCPGFLQGFIT PIVKVTILG---RHKK-VIPFYNMPDFERWRESEEAQANRWTHKYYKG LGTSLATEITEYFQQLSRHLKRFHALQDDDKQYIDLAFNKKKADDRKDWLGAYIPGT--- -QL-DPEIEEIPIADFINKELILFSMADNIRSLPCV--LDGLKPAQRK VIYGLQKRAGNREGKVNDLAGYISSNTAYHHGDQSLVMTIVSMAQDFVGANNINLLEPRG NFGSRFMGGKDASAARYIHTCLSEITKSVYNPLDNSLYKYVQEDESTVEPQW

--- >gi|10281016|dbj|BAB13749.1|	  782 residues, 50 /line  type II DNA topoisomerase [Candida tropicalis] -TES MV---FKEVTIVPGLYKIFDEILVNAADNKIRD--P TMKNIKVKIDPENNTIEVMNDGKGIPVEMHTKEN---MYIPELIFGNLLTSSNYDDNQKK VTGGRNGFGAKLCNIFSTQFEVETADLNTGKLYKQVWTDNMTNVAKPKITTLRTKKEYTK ITFKPDLAKFDMDSLDEDLLAVLRRRVYDLCGTVKNCNIYLNDKRLSISSFKSYVEMYVK AIRE---RSPE-PLT---EDGTSKNFTTIVHEVFNERWEV AFAVSDGT-FNQVSFVNSIATTAGGTHVKYVSDQIINKLVETLSKKEKGKKKLMIKPQEV RDNMF--LFINCLIENPAFTSQTKEQLTTKVSQFGGK--QKFVAN-DNLINR-ILKTSIV DKIRAIANANEDKALQKADGSRK-SRIKGQVSLVDANKAGTKLGHNCTLILTEGLS ALNLAVAGLSVVGRDYYGCFPLRGKLLNVREASADQISKNAEINALKQIIGLQHKKH-Y- TAENIKQLRYGHIMIMTDQDQDGS-HIKGLIINFLETSFPGL--LEIPGFLLEFIT PIVKVTIKTRGSGNNR-VIPFYTMPEFEAWRDGEGSQ-CRWTHKYYKG LGTSTPMEAREYFTALDRHLKKFHALQGEDASYIDLAFSKKKADERKDWLQGFIPGT--- -HL-DPEINEIPISDFINKELILFSMSDNIRSIPSV--LDGLKPGQRK VLYGCIKKKLKSEIKVAQLAGYVSENTGYHHGEQSLVQTIIGLAQNFVGSNNINILKPNG SFGSRAAGGKDFSAARYIFTELNEITRKIFNPLDDPLYNYVQDDEQTVEPEW

--- >gi|10281020|dbj|BAB13751.1|	  782 residues, 50 /line  type II DNA topoisomerase [Candida dubliniensis] -TES MV---FKEVTIVPGLYKIFDEILVNAADNKIRD--P SMKNIRVKIDAENNIIEVMNDGKGIPVEMHTKEN---MYIPELIFGNLLTSSNYDDNEKK VTGGRNGFGAKLCNIFSTQFEVETADLNMGKLYKQSWTNNMSNVSKPKITTLKTKKEYTK ITFRPDLSKFDMDCLDNDLLSVLRRRVYDLCGTVKNCNIYLNEKRLNISSFKSYVEMYVK AIKE---RSPE-PEP---QDGTIKNFTTIVHEVFNDRWEV AFAVSDGS-FNQVSFVNSIATTSGGTHVKYVSDQIINKLVETLSKKEKGKKKLMIKPQEV RDNMF--LFINCLIENPAFTSQTKEQLTTKVSQFGGK--DKFVAN-DNLINR-ILKTSIV EKIRAIANANEDKALQKADGSRK-SRIKGQVNLVDANRAGTKDGHNCTLILTEGLS AMNLAVAGLSVVGRDYYGCFPLRGKLLNVREASADQIAKNAEINSLKQIIGLQHKKV-Y- TAENIKSLRYGHIMIMTDQDQDGS-HIKGLIINFLETSFPGL--LDIPGFLLEFIT PIVKVTVRARGAGGKR-VIPFYTMPEFEHWRDTEGKQ-CRWTQKYYKG LGTSTPMEAREYFTALDRHLKRFHALQGEDKNYIDLAFSKKKADERKEWLQGFLPGT--- -HL-DPEITEIPISDFINKELILFSMSDNVRSIPSV--LDGFKPGQRK VLYGCFKKKLRSEIKVAQLAGYVSENTGYHHGEQSLVPTIIGLAQNFIGSNNINVLKPNG SFGSRAAGGKDFSAARYIFTELSEITRKIFNPLDDPLYTYVQDDEQTVEPEW

--- >gi|10281022|dbj|BAB13752.1|	  779 residues, 50 /line  type II DNA topoisomerase [Candida parapsilosis] -SES MK---FQEVTIVPGLYKIFDEILVNAADNKIRD--P SMKNIKVRIDPENNVIQVFNDGKGIPVEMHTKEK---MYIPELIFGNLLTSSNYDDDQKK VTGGRNGFGAKLCNIFSTQFEVETADLNTGKLYKQTWTDNMTKVGKPKITALKTKKEYTK ITFKPDLSKFDMDSLDEDLLSVLRRRVYDLCGTVRNCNIYLNDKRLSVNSFKSYVEMYVK AIKE---RSPE-PEG---E-GAPKNFTTIVHEVFNDRWEV AFAVSDGT-FNQVSFVNSIATTAGGTHVKYVSDQIISKLVETLSKKEKGKKKLMIKPNEV RDNMF--IFINCLIENPAFTSQTKEQLTTKVSQFGGK--EKFVAS-DNLIAR-VLKTGIA EKIRDIANANEDKALQKVDGSRK-SRIKGQVNLVDANKAGTKDGTKCTLILTEGLS ALNLAVAGLTVIGRDYYGCFPLRGKLLNVREASADQIAKNAEINALKQIIGLQHKKA-Y- TAENIKSLRYGHIMIMTDQDQDGS-HIKGLIINFLETSFPGL--LDIPGFLLEFIT PIVKVTVKGR--GAKK-VIPFYSMPEFEAWREGEGQT-CRWTQKYYKG LGTSTPMEAREYFTALDRHLKRFHALQGEDSNYIDLAFSKKKADERKEWLQNFVPGN--- -QL-DPELNEIPISEFINKELILFSMSDNIRSIPSV--LDGLKPGQRK VLFGCFKRNLKSEIKVAQLAAYVSENTGYHHGEVSLVQTIIGLAQNFVGSNNINILKPNG AFGSRATGGKDAAAARYIFTELNDITKAIFNPLDNPIYSYVQDDEQTVEPQW

--- >gi|10281024|dbj|BAB13753.1|	  779 residues, 50 /line  type II DNA topoisomerase [Candida parapsilosis] -SES MK---FQEVTIVPGLYKIFDEILVNAADNKIRD--P SMKNIKVRIDPENNVIQVFNDGKGIPVEMHTKEK---MYIPELIFGNLLTSSNYDDDQKK VTGGRNGFGAKLCNIFSTQFEVETADLNTGKLYKQTWTDNMTKVGKPKINALKTKKEYTK ITFKPDLSKFDMDSLDEDLLSVLRRRVYDLCGTVKNCNIYLNDKRLPVTSFKSYVEMYVK AIKE---RSPE-PEG---E-GAPKNYTTIVHEVFNERWEV AFAVSDGS-FNQVSFVNSIATTAGGTHVKYVSDQIITKLVETLSKKEKGKKKLMIKPNEV RDNMF--IFINCLIENPAFTSQTKEQLTTKVSQFGGK--EKFVAS-DNLISR-VLKTGIA DKIRDIANANEDKALQKVDGSRK-SRIKGQVNLVDANKAGTRDGLKCTLILTEGLS ALNLAVAGLTVIGRDYYGCFPLRGKLLNVREASADQIAKNAEINSLKQIIGLQHKKT-Y- NAENIKSLRYGHIPIMTDQDQDGS-HIKGLIINFLETSFPGL--LDIPGFLLEFIT PIVKVTVKGR--GAKK-IIPFYSMPEFETWRDGEGQT-CRWTQKYYKG LGTSTPMEAREYFTALDRHLKRFHALQGEDSSCIDLAFSKKKADERKEWLQNFVPGN--- -QL-DPALNEIPISEFINKELILFSMSDNIRSIPSV--LDGLKPGQRK VLFGCFKRNLKSEIKVAQLAAYVSENTGYHHGEVSLVQTIIGLAQNFVGSNNINILKPNG AFGSRATGGKDAAAARYIFTELNDITKAIFNPLDNPIYTYVQDDEQTVEPQW

--- >gi|10281018|dbj|BAB13750.1|	  782 residues, 50 /line  type II DNA topoisomerase [Candida tropicalis] -TES MV---FKEVTIVPGLYKIFDEILVNAADNKIRD--P SMKNIKVKIDPENNIIEVMNDGKGIPVEMHTKEN---MYIPELIFGNLLTSSNYDDNQKK VTGGRNGFGAKWCNIFSTQFEVETADLNTGKLYKQTWTDNMTNVSKPKITTLKSKKEYTK ITFKPDLSKFDMDSLDDDLLAVLRRRVYDLCGTVKSCNIYLNDKRLSISSFKSYVEMYVK AIRE---RSPE-PLA---EDGTLKNFTTIVHEVFNERWEV AFAVGHST-FNQVSFVNSIATTAGGTHVKYVSDQIINKLVDTLSKKEKGKKKLMIKPQEV RDNMF--LFINCLIENPAFTSQTKEQLTTKVSQFGGK--EKFVAG-DNLISR-ILKTSIV DKIRAIASANEDKALQKVDGSRK-SRIKGQVSLVDANKAGTKLGHNCTLILTEGLS ALNLAVAGLSVVGRDYYGCFPLRGKLLNVREASTDQISKNAEINALKQIIGLQHKKH-Y- TAENIKQLRYGHIMIMTDQDQDGS-HIKGLIINFLETSFPGL--LEIPGFLLEFIT PIVKVTVKTRGSGNNR-VIPFYTMPEFEAWRDGEGAE-CRWTHKYYKG LGTSTPMEAREYFTALDRHLKKFHALQGQDSNYIDLAFSKKKADERKEWLQGFIPGT--- -HL-DPEINEIPISDFINKELILFSMSDNIRSIPSV--LDGLKPGQRK VLYGCIKKKLKSEIKVAQLAGYVSENTGYHHGEQSLVQTIIGLAQNFVGSNNINILKPNG SFGSRAAGGKDFSAARYIFTELNEITRKIFNPLDDPLYNYVQDDEQTVEPEW

--- >gi|115534553|ref|NP_503483.2|	  616 residues, 50 /line  Y46H3C.4 [Caenorhabditis elegans]

---MDRHRIRFK-YNG--ADAIDMVFSKKKSEERKDWLSKWMREKKDR KQQGLAEEYLY-DKDTRFVTFKDFVNRELVLFSNLDNERSIPCL--VDGFKPGQRK VLFACFKRSDKHGVKVAQLAGGVADMSAYHHGEQSLMTTIVHLAQDY- ---GGKDSASAQYIFTQLSPVTRTLFPSHDDNVLRFLYEENQRIEPEWYCPISPMV LVNGAQGIDTGWRTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPRRFA CYGEV--- ---ALQSVICMSSMVLFDAAGCLRTSTSPEAITQEFYDSRQEKY LQRKEYLLEVLQAQSKRLTNQARFILAKINKEIVFENKKKVAIVDDLIKMGFDADPVKKW KEEQKLKLRESGEMDED-DLATVAVEDDEGVSSAAKAVETKLSG---YEYLFGMTI LDVSEEETNKLINESEEKMTELRVLKKKTWQDLWHEDLDNFLSELDKQEARERGDQDAML ENAVKKLAADAKSGRGSTKNVCPEVLPSKDGHRIEPRFDAATKAKYEKMTQPKRERVKKE PKKLAWQADCDDDVGVTSDEEVIRKPKPRAERRAAKKPAVEAPAKKAEPKKKKNNKLYDM SGGESADDVGEKEGSDNGSVGSG >gi|32813238|emb|CAE11801.1|	  345 residues, 50 /line  topoisomerase II [Leishmania panamensis]

---TEGDS AKTLCTAGLAVKDRDYFGVFPLRGKPLNVREASLKKLAACEEIQCVMKIMGLDIRQK-Y- --ENTDGLRYGHLMIMSDQDHDGS-HIKGLLINFIHCFWPNL--LRVPGFLQQFIT PIVKARPKGRG-GAGK-AISFFSMPDYFEWKKAIGDNLSNYQIRYYKG LGTSGAEEGREYFENIDRHRLSFVEQDQSEEDRIVMAFGKDRVEDRKEWITNFKTNVNVN ESM-DYSVRQVSYRDFVDKELILFSIADCERSIPSA--IDGFKPGQRK ILFSCFKRNLVNSIKVVQLAGYVSEHSAYHHGEQSLVQTIVGMAQDFVGSNNVPLLRKDG QFGTRLHGGKDHAAPRYIFT

--- >gi|34419280|ref|NP_899293.1|	  597 residues, 50 /line  topoisomerase II large subunit [Vibrio phage KVP40] -MSKQDNFQILSDKQH VLKRPGMYIGSVDREAHERFVLGE-YKQIEYVPGLVKIINEVIDNSLDEAIRT--K FKFANVIEVKVEGNRITIADNGRGIPQDKVIDPHGNELLRPEAAWTRTKAGSNFEDD--R TTVGMNGVGAALTNYFSHQFIGKTCD---GKNTVTVSCSN--NAERIFVRTSKGGTQGTS VEFIPDFNRFGVFGISPQDEEIIKDRLAALSVAFPEITFKYNGKK-HAPTLKQYAKMFG- ---TD-VSF-EFDNVA LFIAASD-EFRHNSFINGVHTINGGTHVDYFSNKLADELIPMIKRKHKINVPKPQL KNGLTIGLFIRNFVD-PKFDSQTKERLTSSQGDVSPY--LK-DISYDKIAKK-ILADDDI IMPIIEALLAKQHAAEAR--ELARKQKK---AQNAKVVDHIKATMPGG---TLFLTEGKS AIGYLI---KVRDSKKHGGIPLRGKVLSTWGKRPAKIMENKELCDIMSVLNIQL---GN- --DDIRDMYYHDIGILVDADVDGKGSIFPLLLAFF-YNWPEL--YK-QKRIKFVRT PVVIATNK--KE-TKWFYSIDEYRKAKLS-KTWKIRYIKG LGSLTEKEYKKVINEPV-FDEIVIDDPSCFELLFGDD-TDKRKDWMTQ

--- >gi|37651488|ref|NP_932362.1|	  607 residues, 50 /line  topoisomerase II large subunit; gp60plus39 [Bacteriophage 44RR2.8t] ---MSDEFKVLTPREH VILRPNMYVGSVAYEPHERFLFGK-FQSVSYVPGLVKIIDEIIDNSVDEGIRTDFK FANKIDIRFDLLEGSVTVVDNGRGIPQSMVETPDG-EMPKPVAAWTQTMAGSNFDDTN-R VSMGMNGVGSSLTNFFSKKFIGETCD---GKNFLTVTCSE--GASNIDWETKPGKIKGTS VYFIPDEKHFEGRTIDQQIIDIISDRITALSVVFPQIKFTINGQIASMK-FADYAKMFG- ---DESLIV-ESDRFS IAICNSPEGFRQVSYVNGLNIKNGGSHIDYLVDGISEELMPAIKKKHKIEISKARV KECLTM-VVVVRGMSNLRFDSQTKERLTNPAGEVKSH--F--DLDFKKLSKQ-IMNTDAI LQPIIEAALARHLAAEKA--AMTKAQKAAAKTNCAKHIKAGEWG-RNDIETTLFLTEGES AIGYL---LKVKDENLHGGYALRGKVMNTWGMKGSDVLKNNELSDICAITGLDLA--NP- --DDISQRKYKNIAIMTDADPDGQGSIYPCLLAFF-ARWPKL--FD-EGSVRFVKT PVVILNKG--KN-TKWFYTLTEFE--KEKK--DYKGWDLRYIKG LGSLREHEYSDVVNNPNYDIVDLGDDWEELFEMLLGDDAALRKEWMSQ

--- >gi|68062299|ref|XP_673155.1|	  426 residues, 50 /line  hypothetical protein PB300551.00.0 [Plasmodium berghei strain ANKA]

-NSN-FNNNK--

-YEEEI-- ---VKIHEK-QHRWEI VISKTDGSQFQQVSFVNSICTTKGGTHVSYIVDQLLNSLSKKANAKNKG--GMEIKSGHI RNHLW--VFVNCLIVNPTFDSQTKETLTTKQSKFGSK--C--ILT-DKTINN-VLKSSIL SNILLWAQAKAQVELRKKMKAGSSKAR-ERIIGIPKLEDANDAGSKYSQECTLILTEGDS AKTSCLAGLSIVGRDRYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFKIMGLDITDKNK- --QDIKGLRYGSLMIMTDQDYDGS-HIKGLLINMIHKFWPSL--LKHKGFLCEFVT PIVKVQKG--NQ-ELSFFTIAEYEQWKENT--NLVGWKIKYYKG LGTSTDKEFKQYFSDIQSHKIVFLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGS--- -YV-DHKEKDLSYYDFVNKELIYYSRYD

--- >gi|111305596|gb|AAI21351.1|	  757 residues, 50 /line  LOC779457 protein [Xenopus tropicalis] MSKSGGGGGAGGGSGGLTWVTLFDNQNASKKEETESNNKNDSSKKMSVERVYQKKTQLEH ILLRPDTYIGSVETVTQSMWVYDEDVGMNCRDITYVPGLYKIFDEILVNAADNKQRD--K NMNCIKISIDPDSNIISIWNNGKGIPVVEHKVEK---MYVPALIFGQLLTSSNYDDEEKK VTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWTNNMLKTTEPKIKHFD-GDDYTC ITFQPDLAKFQMEKLDKDTVALLTRRAYDIAGSCKGVKVLLNGKKLPVNGFRSYVDLYVK DRLD--ETGVA---LKVIHEVANERWDV CLTLSEKG-FQQISFVNSIATTKGGRHVDYVVDQIVSKLIEVVKKKNK--AGVSVKPFQV KNHVW--VFVNCLIENPTFDSQTKENMTLQPKGFGSK--CQL--S-EKFSKA-ASNCGIV ESILNWVKFKAQTQLNKKC---SSVKH-SKIKGIPKLDDANDAGGKHSLDCTLILTEGDS AKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKS-YD DNESLKTLRYGKIMIMTDQDQDGS-HIKGLLINFFHHNWPSL--LK-HSFLEEFIT PIVKATK--NKQ-ELSFYSIPEFEEWKKQTENQ-KLWKIKYYKG LGTSTSKEAKEYFADMDRHRIIFRYAGPEDDAAITLAFSKKKVDDRKEWLTNFMEDRRQR RLHGLPEQ-FLYGTATKHLTYNDFINKELILFSNSDNERSIPSL--VDGLKPGQRK VLFTCFKKKKK-

--- >gi|149040009|gb|EDL94093.1|	  733 residues, 50 /line  similar to topoisomerase (DNA) II beta [Rattus norvegicus] MAKSSLAGVDGALTWVN-NAAKKEELETANKNDSSKKLSVERVYQKKTQLEH ILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD--K NMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEK---VYVPALIFGQLLTSSNYDDDEKK VTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFD-GEDYTC ITFQPDLAKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVK DKLD--ETGVA---LKVIHELANERWDV CLTLSEKG-FQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNK--AGVSVKPFQV KNHIW--VFINCLIENPTFDSQTKENMTLQPKSFGSK--CQL--S-EKFFKA-ASNCGIV ESILNWVKFKAQTQLNKKC---SSVKY-SKIKGIPKLDDANDAGGKHSLECTLILTEGDS AKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKS-YD DAESLKTLRYGKIMIMTDQDQDGS-HIKGLLINFIHHNWPSL--LK-HGFLEEFIT PIVKASK--NKQ-ELSFYSIPEFDEWKKHIENQ-KAWKIKYYKG LGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQR RLHGLPEQ-FLYGTATKHLTYNDFINKELILFSNSDNERSIPSL--VDASKL

--- >gi|7025462|gb|AAF35892.1|	  226 residues, 50 /line  topoisomerase II [Mytilus edulis]

--GS-HIKGLLINFVHHFWPNL--LK-NNVVEEFIT PIVKVTK--GKE-EKSFYSLPEFEEWKRDTDNW-HTYKVKYYKG LGTSTAKEAKEYFSDMDKHKIPFKYQGTEDDASITLAFSKKKIEERKEWLTNFMVERKRR LEMGLPEV-YLYGKETKHISYNEFINRELVLFSNMDNERSIPSL--VDGLKPGQRK VIFTCIKRNLIRELKVAQLAGSVAEQSSYHHGEQSLMSTIINL-

--- >gi|72176533|ref|XP_789474.1|	  123 residues, 50 /line  PREDICTED: similar to topoisomerase II alpha-2, partial [Strongylocentrotus purpuratus]

-MENAEINNIMEILGLKYGNK-YD SPESMRSLRYGKLMIMTDQDPDGS-HIKGLLINFIHSNWPHL--LQ-MNFLEEFIT PIVKVSK-ANET-KLPFYSLLEFEKWKNETYNW-KSWKVKYYKG WL-- --LFSQEV

---