At2g05710.1/MSA

>gi|30678219|ref|NP_178634.2|	  990 residues, 50 /line  aconitate hydratase, cytoplasmic, putative / citrate hydro-lyase/aconitase, putative [Arabidopsis thaliana] ---MYLT--ASSSASSSI-- --IRAASSRSSSLFSFRSVLSPSVSSTSPSSLLARRSFGT ISPAFRRWSHSFHSKPSPFRFTSQIRAVSPVLDRLQR-TFSSMASEHPFKGIF-TT LPK-PG-GG-EFGKFYSLPALND- --PRVDKLPYSIRILLESAI RNCDN--FQVTKEDVEKIIDWE-KTSPKQVEIPFKPARVLLQDFTGVPAVVDLACMRDAM NKLGSDSNKINPLVPVDLVIDHSVQVDVARS-ENAVQANMELEFQRNKERFAFLKWGSTA FQNMLVVPPGSGIVHQVNLEYLGRVVFNTK---GLLYPDSVVGTDSHT TMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLAGKMRNGVTATDLVLTVTQML RK-H-GVVGKFVEFYGNGMSGLSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRS DETVAMIEAYLRANNMFVDYNEPQQDRVYSS-YLELNLDDVEPCISGPKRPHDRVTLKEM KADWHSCLDSKVGF---KGF ---AIPKEA---QE-KVV--NFSF---DGQPAELKHGSVVIAAITSCTNTSNPSVM LGAGLVAKKACDLGLQVKPWIKTSLAPGSGVVTKYLLKSGLQEYLNEQGFNIVGYGCTTC IGNSGEINESVGAAITENDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTV NIDFETEPIGK-GKNGKDVFLRDIWPTTEEIAEVVQSSVLPDMFRATYESITKGNPMWNK LSVP-ENTLYSWDPNSTYIHEPPYFKDMTMDP-P-GPHNVKDAYCLLNFGDSITTDHISP AGNIQKDSPAAKFLMERGVDRKDFNSYGSRRGNDEIMARGTFANIRIVNKLMNGE- VGPKTVH---IPSGEKLSVFDAAMRYKSSGEDTIILAGAEYGSG SSRDWAAKGPMLQGVKAVIAKSFERIHRSNLVGMGIIPLCFK-SGEDADTLGLTGHERYT IHLPTD--ISEIRPGQDVT--VTTDNG--KSFTCTVRFDTEVELAYFNHGGILPYVIRNL SKQ-- >gi|114320610|ref|YP_742293.1|	  914 residues, 50 /line  aconitate hydratase 1 [Alkalilimnicola ehrlichei MLHE-1]

MSDSF-NA RGTLEVG-G-RSYEIFHFDGLRKH --FDIDRLPYSLKVLMENLL RKEDG--VNVTREHIEALANWD-PKSKPKDQIGFTPARVVLQDFTGVPAVVDLAAMRDAM KSMGRDPNLINPLSPVDLVIDHSVMVDHFGS-PEALGLNTKIEFQRNGERYEFLRWGQKA FSNFRVVPPGTGIVHQVNLEYLGQVVFTREE-D---G--V-LRAYPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPISMLIPEVVGVRLTGKLAEGATATDLVLTVTEML RK-H-GVVGKFVEFFGDGLDHLPLADRATIGNMAPEYGATCGIFPIDRETLNYLELSGRD AEQIELVEAYAKRVGLWRETGAR--EAEYSA-VLDLDLSSVVPSIAGPKRPQDRIPLDRA KVAFLDTLDQYLEQHHSAP---ANKD-EERFEGEGGHAAP ---GVDDAH---EK-GAV--EYEM---DGEKHLLKHGSVVIAAITSCTNTSNPAVL LAAGLVAKKAAEKGLKPKPWVKTSLAPGSQVVPAYLERAGLLKPLEALGFHVVGFGCTTC IGNAGPLPEPIQNAVREGDLCVSSVLSGNRNFEGRIHGDVRTNYLASPPLVVAYALAGNM AVDLYKEPLGH-DQDGNPVYLKDVWPSQQEVAELAQKHITSQIYRDKYADVFKGDETWQA IKVT-GGELYDWQP-STYVKNPPYFEGMAAEA-Q-GSAAIEDARCLVYVGDSITTDHISP AGAIHPESPAGHYLREQGVEPKDFNSYGSRRGNHEIMMRGTFANVRLRNKMAPGT- EGGWTTH---VPSGEQMFIYDAAMKYRQEGTPLVVLAGKEYGTG SSRDWAAKGTNLLGIRAVIAESFERIHRSNLVGFGVLPLQFK-EGDSAEGLGLTGQEAFS ISSLEGD---PETVEVKAEGANGTT-TFEALVRIDTPKEWDYFRNGGILHYVLRQL AAKAA >gi|149377906|ref|ZP_01895634.1|	  919 residues, 50 /line  aconitate hydratase 1 [Marinobacter algicola DG893] MSK-

-QSLSKDSL-NT LSSLEAG-G-KTYHYYSLPKAADT-L-- --GNIDKLPFSLKVLLENLL RNEDD--ATVGRGHIDAMVQWM-KDRKSDTEIQFRPARVLMQDFTGVPGVVDLAAMREAV KAAGKDPAMINPLSPVDLVIDHSVMVDKYGD-PSAFKDNVTIEMERNQERYEFLRWGQQA FDNFRVVPPGTGICHQVNLEYLGKTVWSKDQ-D---G--K-TIAYPDTLVGTDSHT TMINGLGILGWGVGGIEAEAAMLGQPVSMLIPEVVGFKITGKLREGITATDLVLTVTEML RK-K-GVVGKFVEFYGDGLKDMPVADRATIANMAPEYGATCGFFPVDEQTIKYMQLTGRE DDQLELVEAYAKAQGLWRQPG-Q--EPVYTD-NLELDMGEVEASLAGPKRPQDRVALKNM KASFELLMETAEGPAESR-EDKLESEGGQTAV ---GVQDSY---EH-AASQ-PMEM---NGEKTRLDPGAVVIAAITSCTNTSNPSVM MAAGLIAQKAVARGLNTKPWVKTSLAPGSKVVTDYLKVGGFQDDLNKLGFNLVGYGCTTC IGNSGPLPDAVEKAIADGDLTVASVLSGNRNFEGRVHPLVKTNWLASPPLVVAYALAGNV RLDLSNDPLGD-DKDGKPVYLKDLWPSQQEIAEAVE-KVKTSMFHKEYAEVFDGDATWKA IKVP-ESKVYEWSDNSTYIQHPPFFQGLKEEP-D-AINDIKDANILALLGDSVTTDHISP AGSFKADSPAGKYLQERGVEPKDFNSYGSRRGNHEVMMRGTFANVRIRNEMLDGV- EGGFTKH---IPSGEQMPIYDAAMKYQEEDTPLVVIAGKEYGTG SSRDWAAKGTRLLGVKAVVAESYERIHRSNLIGMGVMPLQFR-DGVDRKSLKLTGEETIS IKGLSGDIKPGQTLEMTVTYPDGKTETCELLSRIDTANEAVYYRHGGILHYVVREM LKSA- >gi|72162324|ref|YP_289981.1|	  916 residues, 50 /line  aconitate hydratase [Thermobifida fusca YX]

---MSANSF-GS RDTLRVG-D-ESYEIFRLDAI--- --DGVQRLPYSLKVLLENLL RTEDG--VNVTADHIRALANWD-SKAQPSQEIQFSPARVIMQDFTGVPCVVDLATMREAV RDLGGDPTKINPLAPAELVIDHSVIVDVFGR-PDAFERNVEMEYERNRERYQFLRWGQNA FEGFKVVPPGTGIVHQANIEHLARVTMVRN---GQAYPDTCVGTDSHT TMQNGLGILGWGVGGIEAEAAMLGQPISMLIPRVVGFKLTGELPPGTTATDLVLTITEML RE-H-GVVGKFVEFYGEGVASVPLANRATIGNMSPEFGSTAAMFPIDDETIRYLKLTGRS DEQTALVEAYTKEQGLWHDPS-V--EPEYSE-YLELDLSEVVPSIAGPKRPHDRIALSDA KTAWRRDVRDHVNNDGIVT--R-ADEASAESFPASDAPAI SSNGVVTER---PR-KPVKVTL-G---DGTEFTIDHGSVVIAAITSCTNTSNPSVM LGAALLAKKAVEKGLSRKPWVKTSLAPGSKVVTDYYERSGLTPYLDKLGFNLVGYGCTTC IGNSGPLPEEISKAINDNDLAVAAVLSGNRNFEGRINPDVKMNYLASPPLVVAYALAGTM DIDFDTEPLGT-DTDGNPVYLRDIWPSPEEIQEVIDSAIAAEMYQRAYSDVFAGDERWRS LPTP-TGDTFSWDPNSTYVRKPPYFDGMPLEP-E-PVSDIVGARVLAKLGDSVTTDHISP AGAIKPGTPAAEYLMANGVERKDFNSYGSRRGNHEVMIRGTFANIRLRNQIAPGT- EGGYTRDFT-QEGGPVTFIYDAAQNYAAQNIPLVVLGGKEYGSG SSRDWAAKGTRLLGVRAVIAESFERIHRSNLIGMGVLPLQFP-EGQSADSLGLTGEETFS ITGVT-ELNEGR-IPETVKVTTDTGVEFDAVVRIDTPGEADYYRHGGILQYVLRQL INKK- >gi|82702004|ref|YP_411570.1|	  946 residues, 50 /line  aconitate hydratase 1 [Nitrosospira multiformis ATCC 25196]

---MAHNLF-NT LKELSLPTG-KKAKYYSLPALEAAGL-- --GRISRLPVSIRIVLESVL RNCDN--RKVTEAHIKRLADWQ-PTAPRLDEIPFVVSRIVLQDFTGVPLLVDLAAMRSTA KKMGKDPEMVEPLVSVDLVVDHSVQVDYYGT-DDALKLNMEMEFHRNRERYQFIKWGMQA FDTFKVVPPGIGIVHQVNLEYLARGVHEKE---GILYPDTLVGTDSHT TMINGIGVVGWGVGGIEAEAGMLGQPVYFLTPDVVGVNLTGKLSTGVTATDLVLTVTELL RK-S-GVVGKFVEFFGEGTASLTVPDRATIGNMAPEYGATMGFFPVDDATVEYFRGTGRS EEEVAAFQSYFKAQELYGVPRKG--EIDYTR-ELELDLSTVKPSLAGPRRPQDRIELDDV KTRFTELFSRPVMQGGYGRDAAALKLRYKVHGSEEPGPAAAA-ADSASADRNTAAVRPGT ERNIT--EMVNNR---PILAPAEAPVYG---ANDLFDLAHADILIAAITSCTNTSNPSVL LAAGLLAKKAVEKGLSVKCHIKTSLAPGSRVVTEYLRETGLLPYLDKLGFNLAGYGCTTC IGNSGPLSVPIEETVVSNDLVCAAVLSGNRNFEARIHPNIRANFLASPPLVVAYALAGTM LKDLTAEPLGY-GENGQPVWLADIWPRDDEIQSLMKFAANGETFRRLYSNLTQDHPLWND ISSV-SGEVYDWP-KSTYIAEPPFFQDFSLQP-R-PYNEIRNARALAIFGDSVTTDHISP AGSIKDTSPAGKYLLASGVSRSDFNSYGARRGNHEVMMRGTFANVRIKNLMIPGS- EGGITLH---QPDGEQMSIYDAAMRYIAEGIPTVIFGGEEYGSG SSRDWAAKGTQLLGVKAVIAKSFERIHRSNLIGMGVLPLQFK-GDDSVESLGIQGNEAFD IEGLS-SIRPQQDVTLVVRDNTGSRREIDLLCRIDTGIEIDYYRHGGILPYVLREL MKA-- >gi|83814227|ref|YP_445978.1|	  910 residues, 50 /line  aconitate hydratase 1 [Salinibacter ruber DSM 13855] ---MSAP-

-ADLAPDPF-DA LDTFATG-H-GRAYLYRLSALDGV ---DLDRLPVSIRVLLEGLL RECDG--DLVTEEHVRRLAQYD-PAAPTEAAVPFTPSRVLLQDFTGVPSVVDLAALRSAM DRFGAAPDGISPEVPVHLIIDHSVQVDHFGL-PNAVQLNSELEFRRNQERYKFLKWGQQA FDDFRVVPPASGICHQVNLEYVGRGVWTRDTAD---G--T-PLAYPDTLVGTDSHT TMINGLGVLGWDVGGIDAEAALLGQPLYMLMPEVVGVELTGELSEGATATDLVLTITQML RE-Y-GVVGRFVEFFGAGLRTLTVPDRATIANMSPEYGATMGFFPIDGETLDYMRRTNRS EEQVDLVERYTKEQGLFHTPDTP--APDFLD-VLELDLGDVTPSVAGPKRPQDRIRVPEL PDAFADSLTAPSGPTGFGLDADDLGA-- --TGTYDD---GTHTLDLTHGDVVIAAITSCTNTSNPSVM LGAGLLARNAVEAGLTVPPYIKTSLAPGSKVVTDYLQESDLLPFLQELGFATVGYGCTTC IGNSGPLPDPVEDAIEEGDLIVSGVLSGNRNFEGRIHPLVQANYLGSPPLVVAYALAGTV DIDLTTDPIGE-TADGDEVYLRDLWPSSEAVKRLVDTAVKPDFFAAEYEGIEDANETWNE IEIP-EGAVYDWEEDSTYIKEPPFFVDLTPEV-P-PVDSIEDARVLVKVRDSTTTDHISP AGAIPPDSPAGTYLIEQGVEPRQFNSYGARRGNHEVMMRGTFANIRIKNELVPGT- EGGVTKNF--LRDGEVTSVYEAAMDYQAHDVPLVVLAGEDYGMG SSRDWAAKGTDLLGVEAVLAASYERIHRSNLIGMGVLPLQFA-DGADADSLGLDGTETFD IPLDD-DLAPGQEIAVTATAEDGTATTFPTIARCDTPVEVRYYRHGGILHYVLRET LREAPVT-A >gi|114778400|ref|ZP_01453247.1|	  929 residues, 50 /line  aconitate hydratase [Mariprofundus ferrooxydans PV-1] ---MICKALFSDSV---FLSACRD---IVSHLW---IITDVSAIFADI F--- --HNIGAAMNNSF-GA KTSLSVG-D-KTYTYYALKAA--- --GDIDRLPYAMKILLENML RREDG--VNVTADDINFLAKWD-EKAEPNHEIAYMPARVLMQDFTGVPAVVDLAAMRDAV AALGGDTAKIEPLAPAELVIDHSVQVDTFGT-ADAATKNTGIEFQRNRERYNFLKWGQNA FETFKAVPPGTGIVHQVNLEFLARTVFVNNE--GVAYPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPVSMLVPKVVGFKLTGELPEGATATDLVLTIVEML RK-H-GVVGKFVEFYGSGLDSLPLADRATIANMAPEYGATCGIFPIDDETLNYLRLSNRS AENVALVEAYAKAQGMFRDADSP--EAIYSE-YVALDMSTVVPSLAGHKRPQDRIALTES KAKYQQAVETVKAEAGITT- ---HAV--NTTI---NGENVTIDDGAVVIAAITSCTNTSNPSVM VAAGLVAKKAAALGLSAAPWVKTSLGPGSLVVTEYLDKAGLSPELDKLGFNTVGYGCTTC IGNSGPLPAAVSAAIAEGNLAVTSVLSGNRNFEGRVHAEVRMNYLASPPLVVAYAIAGTM NIDLYNDPIGQ-DANGKDLFLRDIWPTQKEVADTVASCVTAEQFEAAYGNVYAGDANWQN LQAP-SGDRFAWDNDSTYIQHPPYFEGMSFEL-D-PVTDIKGARVLALLGDSVTTDHISP AGAIKADSPAGRYLQERGVEAKDFNSYGSRRGNHQIMMRGTFANIRLRNRLAPGT- EGGVTLH---QPSNTLMSIYDAAMQYIDEGVASIILAGKEYGSG SSRDWAAKGPRLQGVQAVIAETYERIHRSNLVGMGILPLQFK-AGESAESLGLTGQESYD FSGIG-DG-SAKELHVTATATDGSVKSFTVDVRIDTPKEVEYYQHGGILHYVLRQL AAEKA >gi|71066615|ref|YP_265342.1|	  939 residues, 50 /line  aconitate hydratase [Psychrobacter arcticus 273-4]

MSDIF-NV KDTIAVD-G-KEYAYYSLPKLTETH--- --ENISKLPFCMKVVLENLL RNEDD-GQSVGKNHIEAVANWD-AGAEASKEIAFMPARVVLQDFTGVPSVVDLAAMRDAV VELGGNAEQINPFIPSELVVDHSVQVDAYGR-EDALDLNEKIEFKRNNERYEFLHWGRNA FKNFVVVPPATGIVHQVNLEYLARVVMAADVDN---G--DGV-E-LTAYPDTVFGTDSHT TMINGIGVLGWGVGGIEAEAAMLGQPSSMLIPQVVGFELKGKLTEGVTATDLVLRVVEML RA-H-GVVGKFVEFYGEGLHSMPLADRATIANMSPEYGATCGIFPIDQMAIDYLRLSGRD EAQIELVEKYAKAQGLWHDADTP--AATYSS-KLELDLSSVQPALAGPNLPQQRINLSDM HKKFGETLTAMTKDRKS---EV-EGKVRFDQEG-GEQEQA KTLAAKPNPFCAEG-STYC-TVKI---EDEEYSLRDGSVVIAAITSCTNTSNPAVM IGAGLVAKKAAAKGLTAKPWVKTSLAPGSKVVTDYLEKAKLMDELEKIGFYLVGYGCTTC IGNSGPLLGAIEGAIEEGDLVAAAVLSGNRNFEGRIHSHVKASYLASPPLVVAYALAGTV DIDLTTHPLGQ-DQEGNDVYLKDIWPTSDEINELIANNIDADMFRKNYGEVFDGSAAWNA ISSA-DSQLYPWSEESTYIKNPPFFDGMTMEP-E-GIPDIEGARILGLFGDSITTDHISP AGNIDADSPAGKYLQERGVMEADFNSYGSRRGNDAVMTRGTFANIRIKNTMMGGK- EGGYTYYFNGDSATLQDGEEMAIYDAAMKYKEDKRPLVVLGGAEYGSG SSRDWAAKGTILLGVKAVLTSSFERIHRSNLVGMGVLPLTFK-AGENAATYNLDGSEVLS ITGLDNGES--KTAKVTATRADGSTESFDVNVMLQTPKEREYVRHGGVLHYVLRQL AADSKNA-A >gi|84687402|ref|ZP_01015280.1|	  932 residues, 50 /line  aconitate hydratase [Rhodobacterales bacterium HTCC2654] -MPP---FEGHRV---VQREEPDM

PIEVGKDTS-KT RKTLSAG-G-STVAYYSIPAAEEAGL-- --GTFSKLPASLKVVLENML RFEDG-GRTVSTDDIKAFSEWADKGGQNPREIAYRPARVLMQDFTGVPAVVDLAAMRDGI KALGGDAEKINPLVPVDLVIDHSVMIDEFGN-PRAFQMNVDREYERNMERYQFLKWGQTA FENFRVVPPGTGICHQVNLEYLAQTVWTDKDQN---G--E-EVAYPDTLVGTDSHT TMINGVAVLGWGVGGIEAEAAMLGQPISMLIPEVVGFKLTGAMVEGTTGTDLVLKVVEML RK-H-GVVGKFVEFYGDGLDNLPLAQRATIANMAPEYGATCGFFPIDGETLRYLEQTGRD KDRIELVEAYAKENGLWRDADY---DPVYTS-TLHLDMGDIVPAISGPKRPQDYVALDQA AGAFDNVVADYRGVDMS---DD-AQDMAAEGPI-AT -KPAV---YAK-SGKV---EGEDYELKDGSVVIASITSCTNTSNPYVM IGAGLVARKANELGLNRKPWVKTSLAPGSQVVTEYLEAAGLQDDLDAIGFDLVGYGCTTC IGNSGPLQPEISKSIADNDLIAVSVLSGNRNFEGRISPDVRANYLASPPLVVAYALAGDM NIDMANDPIAQ-TPDGKDVYLKDLWPSDAEIAELVEKVVTREAFQEKYADVFKGDEKWQA VEVS-GGETYDWPPQSTYIQNPPYFQGMSKDP-G-TIADIKDARVLALLGDMITTDHISP AGSFKAESPAGKYLTERQVAPRDFNSYGSRRGNHEVMMRGTFANIRIKNEMLDGV- EGGYTKGPDGEQTSIYDASMAYQEDGTPLVVVGGIEYGAG SSRDWAAKGTNLLGVKAVIAESFERIHRSNLVGMGVVPFEFT-GGDTRKTLNLTGEETFT ITGLSEDLKPLAVLPCTITYPDGTTKDIELKCRIDTEVEIDYVANGGVLHYVLRNL AKS-- >gi|94491672|ref|ZP_01298882.1|	  917 residues, 50 /line  hypothetical protein CburD_01001064 [Coxiella burnetii Dugway 7E9-12] -MAG---CGLTDF---CRTFECVK-LQP K--- --IGCEVTMADSL-KT RRELTAG-G-KTYHYHSLKAAEDAGL-- --SNIHRLPYSLKILLENQL RHEDG--ETVAQTHIEAFAHWL-KDKHSDREIAYRPARVLMQDFTGVPAVVDLAAMRDAM ARMKGDPTKINPHCPVDLIIDHSVQVDEFGN-EEAFRDNVRIEMERNHERYTFLKWGQQA FRHFQLVPPGTGICHQVNLEYLGRGVWSSQQ-D---G--E-WLAYPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPISMLIPEVIGFYLSGQLREGITATDLVLTVTQML RQ-K-GVVGKFVEFYGPGLAELPLADRATIGNMAPEYGATCGLFPIDAETIKYLELTGRD AEAIELVKAYSKAQGTWHDENTP--EPIFSD-TLSLDLSTVEPSLAGPKRPQDRVPLAKL KKTIEGVIATAERDQEL---DH-- SFQSTGDFDLHHGDVVIAAITSCTNTSNPSVM LAAGLLAKNAVEKGLQRKPWVKSSLAPGSKVVTDYLHKTGLIDYLEKIGFYLVGYGCTTC IGNSGPLPETVAKTVTENDLIVSSVLSGNRNFEGRIHPLVKTNWLASPPLVVAFALAGTT RIDLTKDPLGH-NDRGEPIFLNDIWPSNAEIAKTVMQ-VRNDMFRKEYADVFEGDEEWQR IHVS-AGDTFSWQTNSTYVKNPPFFENMSAKP-E-PLKNIIDARILAILGDSVTTDHISP AGAIKADSPAGKYLIEHGIDIKDFNSYGSRRGNHEVLMRGTFANIRIRNEMLSKV- EGGFTKH---FPDGEQLPIYDAAMKYHSENIPLVVIAGKEYGTG SSRDWAAKGPRLLGVKAVVAESFERIHRSNLVGMGVLPLEFK-NDDNRHSLKLEGNEVID ITGLENDLQPGGDVIMTVKRKDGTIEKIPLHCRIDTQNELAYYQHGGILQFVLRQM LRSS- >gi|92115078|ref|YP_575006.1|	  910 residues, 50 /line  aconitate hydratase 1 [Chromohalobacter salexigens DSM 3043]

---MSEAPQ-NT LSTLDVG-D-RTYHYYSLDKAAQA-F-- --GDASRLPMTLKVLLENQL RYSDD--ESVSPEDMQALVDWQ-KEARSTREIGYRPARVLMQDFTGVPGVVDLAAMRDAV KRLGESADRINPLSPVDLVIDHSVMVDHFGD-PSSFKDNVAIEMERNRERYEFLRWGQQA FDNFRVVPPGTGICHQVNLEYLGKTVWTKEE-D---G--K-TFAYPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPEVVGFKLTGKLREGITATDLVLTVTQML RQ-K-GVVGKFVEFYGDGLKDLPLADRATIGNMAPEYGATCGFFPVDEETLNYMRLTGRD EHQIALVEAYTKAQGLWREPGA---EPIFSD-TLHLDMGEVESSLAGPKRPQDRVALTDM KSTFEKILEDRKPDAAP---TE-QGKWLSEGGQ--- TAVGNEEGA---ES-GDSQ-ACEI---DGENFQLDHGAVVIAAITSCTNTSNPSVM LAAGLLAQKAVEKGLTTKPWVKTSLAPGSKVVTDYLDASGTQNDLNELGFNLVGYGCTTC IGNSGPLPEAIEKAIDDGDLTVASVLSGNRNFEGRIHPLVPTNWLASPPLVVAYALAGNM RIDLSKDPLGN-DRDGNPVYLKDIWPSQAEIATAVE-QVRTEMYRKEYGEVFEGDEIWKS LEVP-ESDVYAWNKNSTYIQHPPFFEGMGKEP-A-PLEDVKNASVLAMLGDSVTTDHISP AGAIKPDSPAGRYLQENGVKPKDFNSYGSRRGNHEVMMRGTFANVRIKNEMLDDV- EGGYTRH---VPSGEQMAIYDAAMKYAEESTPLVVVAGKEYGTG SSRDWAAKGTRLLGVRAVIAESYERIHRSNLIGMGVLPLQFP-EGEDRKSLGMTGDETIS IEGIAD-IEPGGKVTVTIASSKGE-KKIEALCRIDTANEMAYYRHGGILHYVLRSM L >gi|146306932|ref|YP_001187397.1|	  913 residues, 50 /line  aconitate hydratase 1 [Pseudomonas mendocina ymp]

--MPSLDSL-NC RRELKVG-D-ATYHYFSLPEAAQR-L-- --GNIDRLPKSLKVLLENLL RNEDG--KTVQPQDLQAMVDWL-DKRASDREIQYRPARVLMQDFTGVPAVVDLAAMRDAM AKAGGDPQRINPLSPVDLVIDHSVMVDRYAS-SSAFHDNVELEMQRNGERYAFLRWGQHA FDNFSVVPPGTGICHQVNLEYLARTVWTKEE-D---G--V-TLAFPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPEVIGFKLSGKLKEGITATDLVLTVTQML RK-K-GVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGFFPVDEITLGYLRLSGRP DATVQLVEAYSKAQGLWREAGA---EPLFTD-SLSLDLGSVEASLAGPKRPQDRVSLGQV SQAFDDFVGLQLKPSAKE-EGRLLSEGGG--- -GTAVGGDK---QS-GEI--DYED---EGHTHRLKDGAVVIAAITSCTNTSNPSVM MAAGLLAKKAVEKGLQRQPWVKSSLAPGSKVVTEYFNAAGLTPYLEKLGFDLVGYGCTTC IGNSGPLREPIEKAITQADLTVASVLSGNRNFEGRVHPLVKTNWLASPPLVVAYALAGSV RLDLTRDALGT-GKDGQPVYLKDIWPTQAEIAQAIA-QVDTAMFRKEYAEVFAGDEKWRA IDVP-KADTYAWQGDSTYIQHPPFFEDIAGDP-P-RITDIRQARILALLGDSVTTDHISP AGNIKADSPAGRYLREHGVNRADFNSYGSRRGNHEVMMRGTFANIRIRNEMLGGE- EGGNTLH---VPSGEKLAIYDAAMRYQAEGTPLVIIAGKEYGTG SSRDWAAKGTNLLGVKAVIAESFERIHRSNLVGMGVLPLQFK-PGTDRNSLRLSGREVVA VEGLEGV---ELRPQMPLTLIITREDGQHEEVEVLCRIDTLNEVEYFKAGGILHYVLRQM IAS-- >gi|114705365|ref|ZP_01438273.1|	  953 residues, 50 /line  aconitate hydratase [Fulvimarina pelagi HTCC2506] ---MVVPASSTRV---FRRAKAVRPSA--VVSVREG T--- --TRSMSNHPDSF-NC RKTLDVD-G-KPYVYFDLKEAEKNGL-- --EGISRLPFSMKVLLENLL RNEDG--RTVTKEDIHAVSKWLDDKGKAGYEIAYRPARVLMQDFTGVPAVVDLAAMRDAT KQLGADPKKVNPLVPVDLVIDHSVMVDFFAS-PDAFEKNVDAEYGRNKERYQFLRWGSEA FQNFRVVPPGTGICHQVNLEYLGQTVWTRDE-N---GE---TIAYPDTLVGTDSHT TMINGLSVLGWGVGGIEAEAAMLGQPISMMIPEVIGFRLDGALPDGTTATDLVLTVTEML RK-K-GVVGKFVEFFGPGLSNLTLEDQATIANMAPEYGATCGFFPIDKDTIAYLEATGRQ KDRIALVEAYGKAQGMYREDSTP--DPVFTD-TLELDLATVVPSLAGPKRPQDRVALTDA APAFHKALHEIKGGRKKDDNP--QSQGDSRFMDEG- -ATLPNEVP---SD-VAY--RHEV---EGAAHGLSHGDVVIAAITSCTNTSNPNVL VAAGLVARKAHEKGLTVKPWVKTSLAPGSQVVTEYLEKSGLQTDLDKMGFNLVGYGCTTC IGNSGPLPEPISDAINANDLVAASVLSGNRNFEGRVNPDVRANYLASPPLVVAYAIAGTM FKDITKEPLGQ-DKDGNDVYLSDIWPSTHEIAEIVRETVTRDMFENRYADVFKGDEHWRK IDVS-GGLTYDWDDTSTYVQNPPYFDGMDQEP-E-PVEDIKGARILGLFADSITTDHISP AGSIKKDGPAGEYLVSHQVRPVDFNSYGARRGNHQVMMRGTFANIRIKNQMVPGV- EGGVTVH---HPSGEQMPIYDAAMKYKDEGVPLVVFAGKEYGTG SSRDWAAKGTILLGVKAVIAESFERIHRSNLVGMGVVPFVFAEEGQSWEKLGLKGDEKVT IEGLT-DIRPRREMEAVIESADGSKQTVKIKTRIDTDDELSYYKNGGILHYVLRQL AA--- >gi|146337539|ref|YP_001202587.1|	  911 residues, 50 /line  aconitate hydratase 1 [Bradyrhizobium sp. ORS278] ---MGFPR

--MTSLDSF-KC RKTLKVG-T-KSYIYYSLPTAEKNGL-- --KDISKLPYSMKVLLENLL RNEDG--RTVTKDDIVAVSKWL-RKKSLEHEIAFRPARVLMQDFTGVPAVVDLAAMRNAM QKLGGDAEKINPLVPVDLVIDHSVIVNYFGD-NKAFGKNVAEEYKQNQERYEFLKWGQKA FSNFSVVPPGTGICHQVNLEYLAQTVWTKKE-KMTVGRTKG--TFEVAYPDSLVGTDSHT TMVNGLAVLGWGVGGIEAEACMLGQPLSMLLPDVVGFKLTGALKEGVTATDLVLTVTQML RK-L-GVVGKFVEFFGPGLDHLSVADKSTIANMAPEYGATCGFFPVDTATIDYLKTSGRK GPRVALVEAYAKAQGLFRTAKSA--DPVFTE-TLNLDLGDVVPSMAGPKRPEGRIALPAV AEGFATALAGEY --KKPDAAEQ--RFAV---EGKDFDIGHGDVVIAAITSCTNTSNPSVL IGAGLLARNAAAKGLKAKPWVKTSLAPGSQVVAEYLANSGLQKDLDKVGFNLVGFGCTTC IGNSGPLPEEISKSINDNGVVAAAVLSGNRNFEGRVSPDVQANYLASPPLVVAYALAGTV TKDLAVEPIGI-GKDKKPVYLKDIWPTTKEVNDFVKKFVKASIFKKRYADVFKGDTNWRK IKTV-ESETYRWNMSSTYVQNPPYFEGMKKEP-E-PIKDIVEARVLALFGDKITTDHISP AGSIKLTSPAGKFLSEHQVRPADFNQYGTRRGNHEIMMRGTFANIRIKNFMLKGADGNIP EGGLTKH---WPDGEQMSIYDAAMKYQEEGVPLVVFAGAEYGNG SSRDWAAKGTRLLGVRAVICQSFERIHRSNLVGMGVLPLTFQ-EGTSWSSLGLKGGEKVT IKGLQGDLKPRQTLTAEIVSADGAAQQVPLLCRIDTLDELDYYRNGGILHYVLRKL AA--- >gi|76260743|ref|ZP_00768373.1|	  913 residues, 50 /line  Aconitate hydratase 1 [Chloroflexus aurantiacus J-10-fl]

MANSF-GA RSTLTVG-D-RTYEIYRLDALTAHG--- --VNLARLPYSLRILLENLL RHEDG--RTVTADDILALANWQ-PQAEPEREVAFMPARVILQDFTGVPCVVDLAAMRDAM AELGGDPRRINPLQPVELVIDHSVQVDAYGS-EAALLINKDLEFQRNVERYAFLRWGQTA FDNFKVVPPGNGIVHQVNLEYLARVVFTSDE-N---PRATG--P-VQAYPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPLSMLIPQVVGFKLTGRLREGATATDLVLTVTQML RK-L-GVVGKFVEFFGPGLAHLPLADRATIANMAPEYGATCGIFPVDEETLRYLRFSGRS EERVALVEAYFKAQGLFHDEHTP--EAEYST-VLELDLSTVEPSVAGPKRPEGRVPLHEV NRTFHMAVPTIINPTQPDTAL--SAA-- DF-AAT--AVAV---PGADYKLHHGSVVIAAITSCTNTSNPSVM VAAGLLAKKAVEAGLSVKPWVKTSLAPGSKVVTEYLTNAGLLPYLEALRFHVVGYGCTTC IGNSGPLAPEISQTIEQSGLVAVSVLSGNRNFEGRVQQDVKANYLMSPPLVVAYAIAGRI DIDLDKEPLGV-GKDGKPVYLRDIWPSQAEVQQTIETAIQSEMYRRSYASVFVGDERWEN IPVP-AGDRFAWDPQSTYVRRPPYFDQMSPTP-PARVAEIHGARVLAFLGDSITTDHISP AGSIKVNSPAGKYLIEHGVAPADFNSYGARRGNHEVMVRGTFANVRLRNKLAPGT- EGGFTTY---LPTGEVMTIYDAAMRYQADGTPLVVIAGKEYGNG SSRDWAAKGPYLQGVKAVIAESFERIHRSNLVGMGIVPLQFM-PGENAASLGLTGHEVYD VIGLADAIASGFANGRILTVRATAGDGTVREFQVRVRIDTPQEVEYYRHGGILQYVLRQL LAEDQQ--G >gi|117928601|ref|YP_873152.1|	  926 residues, 50 /line  aconitate hydratase 1 [Acidothermus cellulolyticus 11B]

--MTEANSF-GS RSTLAVG-D-ARYTIYRLDAVP-- ---SVHRLPFSLKVLLENLL RTEDG--VNVTADHIRALANWD-PDKEPDTEIQFTPARVLMQDFTGVPCIVDLAAMREAM VALGGDPKRINPLSPAELVIDHSVIADVYGR-PDAFVRNAELEFQRNRERYQFLKWGQRA FDNFKVVPPDTGICHQVNLEYLSRVVFDRD--G-VAYPDTLVGTDSHT TMVNGLSVLGWGVGGIEAEAAMLGQPISMLIPKVVGFRVHGELPDGATATDLVLTVAEML RR-H-GVVGKFVEFYGPGVGNIPLADRATIGNMSPEYGSTCAIFPIDDETLRYLRFTGRS PERVALVEAYAKEQGLWHDP-EH--EPEFSE-RLELDLSTVEPSIAGPKRPQDRIPLTGA KRAFRSALRNYVTDEPADGSLDEGLAESFPASDPVAVEHEHPGDKPRVVAS- AAQGSNGRP---SK-PTL--VTLS---DGTTVELDHGAVVIAAITSCTNTSNPSVM IGAALLAKKAVERGLTPKPWVKTTLAPGSKVVMSYYEAAGLVPYLEKLGFALVGYGCTTC IGNSGPLDEPLSRAINESELAVASVLSGNRNFEGRIHPDTKLNYLASPPLVVAYALAGSM DVDLTTEPLGI-GADGNPVYLRDIWPSEQEISEVMGRAIESRMFVESYRDVFAGDERWNS LQVP-DGELFVWDETSTYVRRPPYFDGMTPEP-A-PLADIVGARALVMLGDSVTTDHISP AGSIKRDSPAGRYLMEHGVQPKDFNSYGSRRGNHEVMIRGTFANIRLRNLLAPGT- EGGVTRH---LPDGELMTVYDAAMRYAAEGVPLIVLAGKEYGSG SSRDWAAKGTALLGVRAVIAESFERIHRSNLIGMGVLPLQFV-DGQNRESLGLTGEETYT IAGLAGAD---HIPRQL---VVRADD---KEFPVIVRIDTPGEAEYYRHGGILPYVLRSI LARPA >gi|115378394|ref|ZP_01465556.1|	  933 residues, 50 /line  aconitate hydratase 1 [Stigmatella aurantiaca DW4/3-1] ---MQAARC---GPRRHLAHPHG-

--EGRRTHMTDSF-GT KSQLKVG-S-ATYDFYSLGKLAQK-N-- --AAVSRLPLSLKVLLENLL RHEDG--RVVKKEHVEKMLAWD-PKATPDTEISFHPARVLLQDFTGVPAVVDLAAMREAL ASMGGDPAKINPRNPADLVIDHSVQVDTFAT-TASYKENAELEFERNRERYAFLRWGSNA FKNFGVVPPDIGICHQVNLEYLAQVTFRQG---NVACPDTLVGTDSHT TMINGIGVVGWGVGGIEAEAALLGQPITMLIPQVVGFKLTGQLPAGATATDLVLTVTQML RK-K-GVVGKFVEFYGNGVKNLSLPDRATIANMAPEYGATIGFFPVDEESLAYLRFTGRP DEVVALTEAYCREQGLFRLDSAP--EPVFSD-TLELDLATVVPSLAGPKRPQDRVPLTDM KGAYEKALVEMLAAGKSKGED---DEGGGKAKAPAA ---PVPPER---LQ-QTS--TVTS---GSESYKLGHGAVVIAAITSCTNTSNPAVL VGAGILAKKAVERGLTSKPWVKTSLAPGSRVVTEYLKEAGLLPYLEGVGFHVVGYGCTTC IGNSGPLTEPVANAVTEGDLVVAAVLSGNRNFEGRINPHVRMNYLASPPLVVAYALAGDV NRDLNKEPVGH-DRNGKPVFLKDIWPTNEEIREIIRTAVKPEQFRRQYAHAMEGDTLWQQ LQVN-KGNTFQWEEKSTYVRKPPFFENLPKEP-A-PLKDIHGAHVLAVLGDSVTTDHISP AGNIAKNSPAAKYLMAEGVEPKDFNSYGARRGNHEVMVRGTFANIRLKNLLVPGV- EGGVTVH---IPTREKTTIYDASMKYQQEGTPLVVLAGAEYGTG SSRDWAAKGTQLLGVKAVIAKSFERIHRSNLVGMGVLPLQFE-AGQDAQSLGLTGHEKFT ITGVAEGLAPQKVLTVKAEG-EGGTKEFKALCRIDTPNELDYYRHGGILQYVLRQL AKA-- >gi|83317406|ref|XP_731148.1|	  914 residues, 50 /line  aconitate hydratase 1 [Plasmodium yoelii yoelii str. 17XNL]

-MKNA---GVNFSNYVKKYCS--KSNNPFENL RKSFNKGNYHYYDLNELND- --SRIKSLPYSIRILLESAI RNCDN--LKVTEENVKTILAWK-ENSKKKKEIPFMPARVLLQDLTGVPCIVDLATMRDTA EFLGGDANKINPLIPVDLVIDHSVQVDYSRS-SKAIEYNEKREFERNLERFKFLKWGMNS FENMLILPPGSGIVHQINLEYLAHCVFKNKN-NNLIYPDSVVGTDSHT TMINGLGVLGWGVGGIEAEATMLGLPISMTLPEVIGINVVGKLSDNLLSTDIVLYITSFL RK-EVGVVGKYVEFFGPSLKDLKLADRATIANMAPEYGATIGFFGIDDTTLEYLKQTGRD NDKINLVRDYLKKNMLYNDY-SE--NLEYTD-VYTLDLSKLSLSVSGPKRPHDNILLHDL HNDFKICLDSPVGFKGYNISKEDQKK-- EI--TFEYKTGNGATYKLSHGSIVLAAITSCTNTSNSCSM IAAGLLAKKAVELGIKPIPYIKSSLSPGSKAVQKYLEAGGLLSYLEKLGFYNVGYGCMTC IGNSGNLDAEVEDVINKHDLVCSSVLSGNRNFEGRIHPLIKANYLASPALVVLLSLIGNV NTDITKYTF---ECNGKIIKALDLIPKKDEINEYEEKYVKAELYKDIYKNIKYVNKYWND IQIK-KNKLFEWDKNSTYIHKPPFFDDMKIQP-Q-KIKDIKNANILLLLGDSITTDHISP AGMIHKKSEAYKFLKSKGVKDDDLNTYGARRGNDEVMIRGTFANIRLINKLCPD-- KGPNTIY---APSNELMSVYEAAMKYKQNNKDVIIIAGKEYGCG SSRDWAAKGSYLLGVKAIIAESFERIHRSNLIGMSVLPLQFL-NNENAQHYNIDGTETFT ILLNEGNLKPGQNITIEMNQ-KGKIIKFDVLCRIDTEIEVQYFKNGGILKYVLRSL VKKEDA--- >gi|18416900|ref|NP_567763.1|	  995 residues, 50 /line  aconitate hydratase, cytoplasmic, putative / citrate hydro-lyase/aconitase, putative [Arabidopsis thaliana] ---MYRRATSGVRSASA--RLSSS LSRIASSETASVSAPSASSLRNQTNRSKSFSSA---LRSFR-VCSAST RWSHGGSWG---SPASLRAQARNSTPVMEKFER-KYATMASEHSYKDIL-TS LPK-PGG-G-EYGKYYSLPALND- --PRIDKLPFSVRILLESAI RNCDN--YQVTKDDVEKILDWE-NTSTKQVEIAFKPARVILQDFTGVPVLVDLASMRDAV KNLGSDPSKINPLVPVDLVVDHSIQVDFARS-EDAAQKNLELEFKRNKERFTFLKWGSTA FQNMLVVPPGSGIVHQVNLEYLGRVVFNSK---GFLYPDSVVGTDSHT TMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLDGKLKEGVTATDLVLTVTQIL RK-H-GVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLEYLKLTGRS DETVSMIESYLRANNMFVDYNEPQQERAYTS-YLQLELGHVEPCISGPKRPHDRVPLKDM KADWHACLDNPVGF---KGF ---AVPKEK---QE-EVV--KFSY---NGQPAEIKHGSVVIAAITSCTNTSNPSVM IGAALVAKKASDLGLKVKPWVKTSLAPGSRVVEKYLDRSGLRESLTKQGFEIVGYGCTTC IGNSGNLDPEVASAIEGTDIIPAAVLSGNRNFEGRVHPQTRANYLASPPLVVAYALAGTV DIDFEKEPIGT-RSDGKSVYLRDVWPSNEEVAQVVQYSVLPSMFKSSYETITEGNPLWNE LSAP-SSTLYSWDPNSTYIHEPPYFKNMTANP-P-GPREVKDAYCLLNFGDSVTTDHISP AGNIQKTSPAAKFLMDRGVISEDFNSYGSRRGNDEVMARGTFANIRIVNKLLKGE- VGPNTVH---IPTGEKLSVFDAASKYKTAEQDTIILAGAEYGSG SSRDWAAKGPLLLGVKAVIAKSFERIHRSNLAGMGIIPLCFK-AGEDAETLGLTGHERYT VHLPTK--VSDIRPGQDVT--VTTDSG--KSFVCTLRFDTEVELAYYDHGGILPYVIRSL SAK-- >gi|71033859|ref|XP_766571.1|	  912 residues, 50 /line  aconitate hydratase [Theileria parva strain Muguga]

-MFVSFGEK---L--- -GLKS---SPSVLRQMKNFSS--SRPNPF-EK VKK-TLA-G-TNKKYFSLRDLKD- --PRLFELPFSIRVLLEAAV RNCDE--FSTTSNDVEKILGWA-KNSLNQTEIPFIPSRVLLQDFTGVPTIVDLAAMRDFV AKSGKDPTRINPLVPVDLVIDHSVQVDFSRD-SKALALNQETEMNRNSERFRFLKWGAQT FKNTLIVPPGSGI---VNLEFLARCLFDKN---DLLYPDSVVGTDSHT TMINGLGVVGWGVGGIEAEATMLGQPISMLLPQVVGFELVGKPSENVFSTDVVLAVTSLL RSGA-GVVGKFVEFFGEGVKYLSLADRATIANMAPEYGATVGFFPIDQLTLDYLLQTGRP NEKVDLLERYSKENLLHTSSS-NAGEIKYST-VVRLDLSTLTPSIAGPKRPQDNIPLHLV KSKYSELLTSK-DT---KGY ---GLDKL-S-NKV--KFTY---KGKEYELDNGSVVIASITSCTNTSNPSVM LAAGLLAKNAVEHGLSVKPYIKTSLSPGSKTVTRYLELSGLIGYLEKLGFYIAGYGCMTC IGNSGELDPEVTEAVVNNKLVVSSVLSGNRNFEGRVHPHTRANFLASPPLVVAFALAGNV NFDLMNEPLGVSTKTGKPVFLHDLLPSKEEVSSLEAQFVKASLFNDVYHNITEGSDSWRK LNAP-KTELYPWDELSTYIQHPPYFKGMHLDKLN-EVKPITDARVLLLLGDSITTDHISP AGNIAKNSPAARFLMENGVEQKDFNSYGSRRGNDKVMSRGTFANIRINNLLCPG-- QGPNTVH---FPTNKLMSVYDASELYQRDNTPLVVVAGKEYGTG SSRDWAAKGPLLLGVKAILAESFERIHRTNLVGCGILPLQFL-DGQNATTLNLTGTEKFT VHL-GSDVVPGSLVR--VTTDTG--LSFDTKCRVDTQIESEYYKHGGILQYVLRSI CKSD- >gi|49659878|gb|AAT68238.1|	  1055 residues, 50 /line  iron regulatory protein-like protein [Toxoplasma gondii] ---MRILVPLVFLAAQIPPASLERVSVSGFLPRALLFRRVPLPRPICTARCLEVAQARRP RNPFLLPVSSFLLPGSMKALSNIVLPRKGISVA---ARSTASATAASQPLPR-NSRALSK ACALPASQA---FEGSRRSAGAKEAHVPERHTR-LHSALTQSRKMSTSRGNPF-AY VAK-TLA-G-TEKTYYDIGALQD- --DRLKTLPFSIRVLLESAV RNCDG--FSIKPEDVQTILDWQ-KASQAQKEIPFMPARVLLQDFTGVPAVVDLAAMRDAM ARLGGPPSSINPLVDVDLVIDHSVQVDFSRS-PEAFEKNLAKEMERNSERFSFLKWGSTA FSNMLIVPPGSGIVHQVNLEYLARVVMDKKV-G---D--R-AVLYPDSLVGTDSHT TMINGLGVVAWGVGGIEAEAVMLGQQISMVLPQVVGFELTGQMPPSVTATDLVLTVTNIL RK-K-GVVGKFVEFYGPGVQTLTLADRATVANMAPEYGATMGFFPVDEQTLRYLKQTGRP DEKVDLIEAYTKANHLFASPSV-HAEIAFSD-RVSLNLSELEPCVAGPKRPQDRVPLSEV KEDFQVSLRNPVGF---KGF ---GLSEEQ---AE-KKV--EMTF---RGKKYTLTHGSVVIAAITSCTNTSNPGVI LGAAMLARNALEKGLSVPPYIVTTLSPGSRAVTEYLARSGLLKDLEKLGFYTAGYGCMTC IGNTGDFDPEVSAAISQGDLVVAAVLSGNRNFEGRVHPLTRANFLASPPLVVAYALAGRV DFDFEEEPLGN-DKEGNPVFLRDIWPSREQIAEVEAKALSASAFVKVYEHITEGTPAWNA LKTAKASDLFDWDEKSTYIHNPPFFQTMQKEP-A-PIEDIVDAYCLLNLGDSITTDHISP AGNIAVNSPAAKYLQSKGVERKDFNTYGARRGNDEIMVRGTFANIRLVNKLCP-K- DGPKSVH---VPSGEVLPVYDVAMKYKAERKPMIVLAGKEYGSG SSRDWAAKGPYLMGVKAIIAESFERIHRTNLVGMGILPLQFQ-EGQNAESLGLTGKEQFN ISL--N--KGEIIPGSLMT--VKTSDG--KAFDVRCRIDTELEVKYFQNGGILHYVLRNL TKQHSGE-N >gi|118063248|ref|ZP_01531589.1|	  918 residues, 50 /line  aconitate hydratase 1 [Roseiflexus castenholzii DSM 13941]

-MTNLNDPF-NA RAPLVVG-G-QTFIIYRLDALARRVG-- --ADLARLPFSVKVLLEALL RNVGD--GFTTIDDVAALAQWT-PASAGQREVAFKPARVLMQDFTGVPAVVDLAAMRDAM AHLGGDPAKINPLVPADLVIDHSVQVDAFGH-GMALVLNAQLEFERNRERYEFLRWGQQA FANFRVVPPATGICHQVNLEYLATVVMTREI-D---G--E-LVAMPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAVLLGQPLAMLTPEVVGVKLTGALRPGATATDLVLRVTEML RR-H-GVVDKFVEFCGPGLSALSLADRATIANMAPEYGATCGFFPVDAETLAYLRGTGRS DDLVALVEAYCREQGLFRTDDSP--IPEFNT-LLELDLSTVEPSVAGPRRPQDRVPLTDL KASFNQAMRTIFGREAPAYEGNGERRR- ---ERRDLY---AA-SRV--PVTL---NGQATALTHGSTIIAAITSCTNTSNPSVM IAAGLLAKKAVEKGLRVPPYVKTSLAPGSRVVSEYLAQSGLQEYLDQLGFNVVGYGCTTC IGNSGPVADEIAQAVKAGNLVVSAVLSGNRNFEGRINPVVRANYLASPPLVVACAIAGTV DIDMNREPLGV-GIDGEPVYLADIWPSAEEVAEVMAASLNADLFRQQYANVFTGNETWNA IPVS-GGDLYAWNPDSTYIQNPPYFRDMTREV-P-PLASIRGARALALLGDSVTTDHISP AGSIAKDSPAGRYLIERGVQPADFNSYGARRGNHEVMMRGTFANIRLRNAMVPGV- EGGYTIY---LPTGEQMSIYDAAMRYQADGTPLVVLAGKEYGTG SSRDWAAKGTFLLGVRAVIAESFERIHRSNLVGMGVLPLTFA-PGESWQSLGITGREIFT IEGIE-TLRPGQELTVHAQRPDGSAFTFTVKARINSEGELAYYRNGGILHYVLRQL AEQEEPAAV >gi|88812882|ref|ZP_01128126.1|	  917 residues, 50 /line  aconitate hydratase 1 [Nitrococcus mobilis Nb-231]

MSNSF-NT RSTLEVD-G-DPYQIYRFEALKSK --YDVDRLPYSLKILLENLL RKEDG--RHVTEQDIEALLNWE-PMAEPGVQIAFTPARVVLQDFTGVPAIVDLAAMRDAM QRLGGEPKLINPLEPADLVIDHSVMVDYFAT-PNALKKNTELEFQRNEERYKFLRWGQKA FANFRVVPPGTGIVHQVNLEYLAQVVFTKTT-P---P--A-TLAYPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPITMLLPQVVGFKLTGKLSEGATATDLVLTVTQML RQ-K-GVVGKFVEFYGDGLDNLPLADRATIANMAPEYGATCGIFPIDRETLRYLELSGRD PARLALVESYAKLQGLWRESGSR--EADYSD-TLALDLGAVVPSLAGPKRPQDRIALTNA RQAFLGTLRQDLESRHALP---ANHE-EERFASEGGDTAI ---GWQGGH---ET-GAI--EIEL---GAEKHLLKHGAIVIAAITSCTNTSNPAVL IAAGLVAKKANALGLKVKPWVKTSLAPGSQVVPAYLEKAGLLGELAALGFNVVGFGCTTC IGNSGPLPEAIAQAIREGDLVVASVLSGNRNFEGRIHQDVRANYLASPPLVVAYALLGSM ASDPYREPLGR-DRNGKAIYLKDVWPSQREITELMGNNISSTMYREQYADVFAGSEAWQA LPVP-EGEIYQWP-ESTYVKHPPFFEGMSLEP-P-GPPKIEAARCLIMLGDSITTDHISP AGAIKPDSPAGHYLQQHGVAPKDFNSYGSRRGNHEVMMRGTFANIRLRNKLAPDT- EGGWTTH---FPSDTQMSIFDAAQRYQETMTPLVVLAGKDYGAG SSRDWAAKGTKLLGIRAVIAESFERIHRSNLVGFGVLPLQFK-PEESAERLGLCGKEIFS IGTLAG--EPG-SVSVKAVTETGEVTEFEATVRIDTPTEWDYYQHGGILHYVIRAL AKQSEA--S >gi|121998188|ref|YP_001002975.1|	  914 residues, 50 /line  aconitate hydratase 1 [Halorhodospira halophila SL1]

MTDSF-NA RTTLQAG-G-KAYEIYSLDGPRRD --YDVDRLPFSLKILLENLL RKEDG--VNVTREHIEAVLNWD-PKATPKDQIAFTPARVVLQDFTGVPAVVDLAAMRDAM KNLGGDPSRINPLSPADLVIDHSVMVDHFGN-RQALQLNTEIEYQRNRERYEFLRWGQTA FSNFRVVPPGTGIVHQVNLEYLGQVVFRNEN-G---D--T-PQAYPDTLVGTDSHT TMINGLGILGWGVGGIEAEAAMLGQPISMLVPEVVGFRLEGKLPEGATATDLVLTVTEML RK-K-GVVGKFVEFFGDGLDHLPLADRATIANMAPEYGATCGIFPVDKETLAYMELSGRE QELIDLTEQYAKAQGMWRETGSR--EAEYSD-TLSLDLSTVVPSLAGPKRPQDRVSLDAA KASFKQTLQDHLRAHHTVPTD---AA-EEHFESEGGHSAP ---GIDDAH---ER-GAV--EIEI---GGRKEMLKHGDVVIAAITSCTNTSNPAVL VAAGLVAKKARERGLMPKPWVKTSLAPGSQVVPAYLEQAGLLDDLEHLGFSVVGFGCTTC IGNSGPLPEAVAEGIREGDLCVTSVLSGNRNFEGRIHQDVRANYLASPPLVVAYALAGTM ARDLYKEPLGT-DNQGRDVYLKDIWPSQQEVADLVRGNISAEMYREQYANVFDGDAAWQS IDAP-SGELYDWR-ESTYVKNPPYFQGMNQTP-Q-PLQDIRGARCLIYVGDSITTDHISP AGAIHPDSPAGQYLQEQGVAPKDFNSYGSRRGNHEVMMRGTFANVRLRNKMAPGT- EGGWTTH---VPSGEQTSVYDASMRYQQADTPLIVLAGKEYGTG SSRDWAAKGTNLLGIKAVIAESYERIHRSNLVGFGVLPLQFQ-DGENAETLGLKGDEAFD IEGITE--QP-RTVRVLARRDDGTETTFEARVRVDTPQEWEYYRHGSILHYVLRGL AGTA- >gi|149918462|ref|ZP_01906952.1|	  941 residues, 50 /line  aconitate hydratase [Plesiocystis pacifica SIR-1] ---MGTPAGLRYSP---PAERPLDPPEPALHRN---LISEK---

--Q-PVATSALPN-DI RESIALA-DGSQGVIYRLGALEAAGW-- --TELAKLPFSIRVLLESAL RNHDG--FLVTDDDVRTIASWK-PQGE-RKEIPFIPARVILQDFTGVPAVVDIAACRNAM VELGGDPQKVNPAVNVDLVIDHSVQVDVDGSHTDALLRNLDIEYKRNQERYEFLKWGQQN LANFGAVPPGRGIVHQVNLEWIAQVAFRKQT-T---GP-DGAEE-VRYYPDSLVGTDSHT TMINGIGVLGWGVGGIEAEAVMLGQPVYMLAPDVIGFKLTGKLRAGVTATDMTLRIVELL RA-K-GVVGKFVEFYGPGLDHLSLSDRATIANMAPEYGATCGFFPVDDQSLAYMRLTGRD EDHVKNVETVLRAQGLFRTAETP--DPEFTD-SLELDLADVDPGLAGPKRPQDRVNLSAM KTHFNESLTAKLGLHGHG-- LAEGE---LG-NKA--TVNH---KGTQFELTHGDVVIAAITSCTNTSNPAVM LAAGLLARNAVAKGLHTKPWVKTSLAPGSRVVTEYYDKAGLSDDLAKLGFNLVGYGCTTC IGNSGPLPEVIDSAISDNKLVVGSVISGNRNFEGRVHNKVKASYLASPPLVVAYAIAGTL DINFDEDPIGK-DAAGVDVFLKDIWPGDEELRQVVHSSINPEMFRAKYGDV-TAEPRWDS IEVA-DSALYPWNSESTYVQQPPFFQGITPEV-P-AVQPIAGARVLLKLGDSVTTDHISP AGSFPAEGPAGKYLIDKGVQKAAFNSFGSRRGNHEVMMRGTFANVRIRNQIAPGT- EGGYTKY---WPTGEVEFVYDAAMKYVESNTPLVVLGGVQYGTG SSRDWAAKGTLLLGVKAVITKSFERIHRSNLVGMGVLPLCFA-DGEGADELGLDGSESFD IPITDD-VQPLSKLTVTATKADGSKVEFETTVRLDTPVEVDYYKNGGILQTVLRNM AKG-- >gi|21227630|ref|NP_633552.1|	  942 residues, 50 /line  aconitate hydratase [Methanosarcina mazei Go1] -MLEV---

--KSKMREGPDPF-GV RDSIETT-A-GKATIYRLGKLEEKGF-- --EGISLLPYSIRILLESLL RHADTQKKTITVEDVEALARWS-PENISEKDIPFIPSRVIMQDFTGVPAVVDLAALRSAM ERLGGDPAKINPVIPADLVIDHSVQVDSYGT-AYSLGENEKKEFERNRERYTVLRWAQKA FDNFRVVPPGRGIIHQVNLEYLTPLVHLSEK-E---G--E-LFAFPDTLVGTDSHT TMINGIGVLGWGVGGIEAEAVMLGQPYYMPVPEVVGFKLYGKLEPGVTATDLVLTITKML RK-H-GVVGKFVEFYGPGLNSLSLPDRATISNMAPEYGATLGIFPPDQETLDYMKRTGRS DEQVDLVKKYLEAQDLLYSANKP--EPVFSS-NLELDMGTVKPCLAGPRRPQDQLFLNEV SENFCETMRQTFIRKKEGGTDL-ARD-PAYLRWIGE-GGA ---PVEETEAQVAR-ETE--KVGP---VEKDFRVTHGSVVIASITSCTNTSNPSVL IGAGLLAKKAIERGLKVKPFVKTSLSPGSRVATEYLGAAGLLPYLEALGFHQVGYGCTTC IGNSGPLPEHVSKEIEEKDLTVAAVLSGNRNFEGRINPLVKANYLASPPLVVAYAIAGTV NINFETDPLAY-DPNGIPVYLRDIWPMQDEIKQVEKESVRPEMFKKEYSGVLEGAKLWKE LEVP-EGTLYEWIPTSTYIQEPPYFVDFPLTS-P-LLGDIRNARVLALFGDSITTDHISP AGDIPAESPAGRYLMSWGVDQKDFNSYGSRRGNHEVMMRGTFANIRLRNRLVS-K- EGGWTVYH--LKGEDFPPEACGEGMPIYDASLLYAENNVPLIVIAGKEYGTG SSRDWAAKGTFLLGVKAVIAESFERIHRSNLVGMGVLPLQFK-AGENADSLGLTGKESYD ILGIEK-MEPHGELTVLARDDSGKETEFKATLRLDSAVEIEYYRNGGILHKFLRDS VKK-- >gi|50086100|ref|YP_047610.1|	  917 residues, 50 /line  aconitate hydratase [Acinetobacter sp. ADP1]

---MASYSKINSF-NA LKTLNVG-S-TAYQIFSLHQAQAK-L-- --GDIEKLPKSLKVLLENLL RFEDD--QTVLATHIEALVKWQ-NTKTSDQEIQYRPARVLMQDFTGVPAVVDLAAMRAAM AKAGGDPEKINPLSPVDLVIDHSVMVDHFAS-DAAFEENVDIEMQRNGERYQFLRWGQSA FNRFSVVPPGTGICHQVNLEYLAQAVWTGED-Q---G--Q-TFAFPDTLVGTDSHT TMINGLGVLGWGVGGIEAEAAMLGQPISMLIPEVIGFKLTGKLREGITATDLVLTVTQML RK-K-GVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGFFPVDDITLDYMRLTGRD ADRIALVEAYSKEQGLWRHAG-D--EPVFTD-TLTLDMDTVEASLAGPKRPQDRVLLAKV PEAFQAVMDLSLTAAKPE-KERLENEGG-GGT ---AVDAEQSH-FE-QQP--YYEM---DGQRYELNHGDVVISAITSCTNTSNPSVM LAAGLLAKKAIEKGLQRKPWVKSSLAPGSKVVTDYLAAAGLTPYLDQLGYNLVGYGCTTC IGNSGPLPDPIEAAVQKYDLNVASVLSGNRNFEGRVHPLVKTNWLASPPLVVAYGLAGTI RKDLTSEPIGQ-GKDGEDIYLKDIWPTSAEIAEVLQ-KVNTDMFHKEYAAVFEGDESWQS IQIP-QSQTYEWAEDSTYIRHPPFFEGIDQPP-E-AITNIESARVLAVLGDSVTTDHISP AGNIKKDSPAGRYLQEHGIQPKDFNSYGSRRGNHEVMMRGTFANIRIKNEMLGGE- EGGNTIY---IPSGEKLAIYDAAMRYQKDDTPLVIIAGKEYGTG SSRDWAAKGTNLLGIKAVIAESFERIHRSNLVGMGVLPLQFI-DGQNRQSLKLTGQEEIS ITGLSDQIQPHQSLDITVKREDGSTDTFKVLCRIDTLNEVEYFKAGGILHYVLRNL IAA-- >gi|21231308|ref|NP_637225.1|	  922 residues, 50 /line  aconitate hydratase [Xanthomonas campestris pv. campestris str. ATCC 33913]

MSDSF-ST RTSLEVN-G-QRYDYYSLPKLGER --FDVARLPYSMKILLENLL RHEDGG-VTVGKDHIEAVAKWD-PTAEPDIEIAFMPARVVLQDFTGVPCVVDLAAMRDAV VKLGGNADQINPQIPSELVIDHSVQVDVFGK-PEALDLNGKIEFQRNQERYGFLRWGQKA FDNFKVVPPNTGIVHQVNLENLARVVMSADK-D---G--T-QIAYPDTVFGTDSHT TMINGIGVLGWGVGGIEAEAAMLGQPSSMLIPQVVGFKLTGKLPEGATATDLVLTVTQML RK-H-GVVGKFVEFYGEGLQHLPLADRATIGNMAPEYGATCGIFPVDNESLTYLRLSGRS EEQIALVEAYAKAQGLWHDADTP--HAQYSA-TLELDMGDVKPSLAGPKRPQDRVLLEDM QSNYRESLKPFAEARSKRLADT--KQ-EDRLKNEGG-GGT ---AVGAKASQA-E--SAGD---SGAGWQLRDGSVVIAAITSCTNTSNPAVM LGAGLLARNAAAKGLKAQPWVKTSLGPGSRVVTDYLSKAGVLADLEQLGFYVVGYGCTTC IGNSGPLPEDVSAAIAKDDLVVTSVLSGNRNFEGRVHPEVKMNYLASPPLVVAYAIAGTT DIDLTRDPLGT-GSDGQPVYLRDIWPSNKEIGDTIAATVGPEMFKQNYADVFKGDTRWNT IASP-DGALYEWDAGSTYIKNPPYFEGMTMQV-G-HVDDVHGARIMGLFGDSITTDHISP AGNIKKDSPAGRFLQERGVQPADFNSYGSRRGNDDVMVRGTFANIRIKNLMFGGE- EGGNTLY---FGKDGATPEKLAIYDAAMKYKADGVPLVVLAGKEYGTG SSRDWAAKGTNLLGVKAVVAESFERIHRSNLVGMGVLPLQFL-EGENAQTLGLDGSEVLD ITGLQDGAS--RRATIDAKKSDGSVKQFQVKVLLLTPKEVEYFKHGGLLQYVLRQL AARKA---A >gi|115450595|ref|NP_001048898.1|	  986 residues, 50 /line  Os03g0136900 [Oryza sativa (japonica cultivar-group)] MPPLT--SALLSRSSSTR-- --IPAAAAAAAAISNPAGAAASSSSPSPPPPSSRPRPASP FASGLAGRIFGGRRAAARSSSSAAAVFER-RFASAAAKNSYDEIL-TG LAK-PGGGA-EFGKYYSLPALSD- --PRIERLPYSIRILLESAI RNCDE--FQVTGKDVEKILDWE-NSAPKQVEIPFKPARVLLQDFTGVPAVVDLACMRDAM SKLGSDPNKINPLVPVDLVIDHSVQVDVARS-ENAVQANMELEFHRNKERFGFLKWGSTA FRNMLVVPPGSGIVHQVNLEYLARVVFNN---GGILYPDSVVGTDSHT TMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLTGKLRNGVTATDLVLTVTQML RK-H-GVVGKFVEFYGGGMSELSLADRATIANMSPEYGATMGFFPVDGKTLDYLKLTGRS DDTVAMIESYLRANKMFVDYNQPEAERVYSS-YLELNLEEVEPCLSGPKRPHDRVTLKNM KSDWLSCLDNDVGF---KGF ---AVPKES---QG-KVA--EFSF---HGTPAKLKHGDVVIAAITSCTNTSNPNVM LGAALVAKKACELGLEVKPWIKTSLAPGSGVVKKYLDKSGLQKYLDQLGFHIVGYGCTTC IGNSGELDETVSAAISDNDIVAAAVLSGNRNFEGRVHALTRANYLASPPLVVAYALAGTV NIDFEKEPIGI-SKDGKEVYFRDIWPSTEEIAEVVKSSVLPDMFKSTYEAITKGNPMWNE LSVS-ASTLYPWDPTSTYIHEPPYFKDMTMSP-P-GPRPVKDAYCLLNFGDSITTDHISP AGSIHPDSPAARYLKERGVERKDFNSYGSRRGNDEIMARGTFANIRLVNKFLKGE- VGPKTIH---IPSGEKLSVFDAATKYKNEGHDTIILAGAEYGSG SSRDWAAKGPMLQGVKAVIAKSFERIHRSNLAGMGIIPLCFK-SGEDADTLGLTGHERFT VHLPAN--VSEIKPGQDVT--VTTDNG--KSFTCTLRFDTEVELAYYDNGGILPYVIRKI AEQ-- >gi|118346197|ref|XP_977148.1|	  984 residues, 50 /line  aconitate hydratase 1 family protein [Tetrahymena thermophila SB210] ---MYRKITCNFSALNNP-- --FQ --KN FKQ-LKVEG-KNYNFYSLPDLHDARLGNNNKKLALFVYIFLSLLLCFNPPPTFNFQIRPK CFLLKWIQLKTVERREKKREKKTIFKTSYFSQSIFKIFFIINYKIEKLPYSVRILLESAV RNCDE--FNVKKADVEKILAWE-KNSTQQIEIPFKPARVILQDFTGVPAVVDFAAMRDAM VRLGGDPNKINPLCPVDLVIDHSVQADVARD-LKAFEKNEEIEFNRNYERFEFLKWGQKA LNNFTIVPPGSGIVHQVNLEYLARVVFNNE--NGVLYPDSVVGTDSHT TMINGLGVLGWGVGGIEAEAVMLGQCISMVLPEVVGFKLYGKLKEHVTATDLVLTCTQML RK-R-GVVGKFVEFFGPGCENLSLADRATIANMAPEYGATMGYFPIDAQSVDYLKLTGRD SHKVKVIESYLREQGLFRTSSSKD--PVYTGAVLELDLASVQPCISGPKRPHDRVPLNEM KSEWNQILTAKTGF---KGF ---GLTEQQ---SK-KTH--TFNY---KGTDYTLSNGSVVVAAITSCTNTSNPDSM VAAGLLAKAAVEKGLNVKPYIKTTLSPGSGVVTKYFVESGVQSYLEQLGFTTAGYGCMTC IGNTGELEPEVDQAIRQGDVVAAAVLSGNRNFEGRIHPLTRANYLASPALVVAYALAGTV NIDFETEPIGT-DKHGKAVFLKDIWPSRTFTQDTVHKSLRPEMFSEVYKRISQGTARWNA LKAS-DKKVYDWKAESTYIHNPPFFQTTELVP-K-PVQSIKSAYCLLNLGDSITTDHISP AGNIAKNSPAARYLNERGIQSKDFNTYGARRGNDEIMARGTFANVRLINKMMDKV- -GPETVH---IPSGQKLAVFDAAEKYQKEGHQLIVLAGQEYGSG SSRDWAAKGPYLQGIKAVIAQSYERIHRSNLVGMGILPCEFL-NGQNADSLGLNGHETFN IDLKGGNLKVNEVLT--VTTSTG--KSFQVKTRLDTDVEIAYFQNGGILQYVLRKL VKGEA---Q >gi|149737063|ref|XP_001497856.1|	  1028 residues, 50 /line  PREDICTED: hypothetical protein [Equus caballus] ---MPQQLLSGLLLVTPP-ETGIEVNIPDSFYIPFLDPQEEDRDYLSTRHSRRVEESVLE RHGHSRYRHVCVTPGALGTLCK-QRRRGGKQEAGRGGAGDAGPSASSIPLPSLVPSPLLP FRAFLPEFSLSGYPAVPPVRSIRQARLDTNGKLVVHRDTRPAGIMSNPFAHLA-EP LDPAQ-PEKKFFNLNKLKD- --SRYGRLPFSIRVLLEAAV RNCDQ--FLVKKNDIENILDWN-VTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAV KKLGGDPEKINPVCPADLVIDHSIQVDFNRR-TDSLQKNQDLEFERNRERFEFLKWGSQA FHNMRIIPPGSGIIHQVNLEYLARVVFDQ---DGYYYPDSLVGTDSHT TMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGNPHPLVTSTDIVLTITKRG QP-C-GVVVKFAQRVSLGVASTLLSDRAPLVEFTPSASAAQSFTGLDPRRLATDVSSGRD EDKVKQIKKYLQAVGMFRDFSDPSQDPDFAQ-TVELDLKTVVPCCSGPKRPQDKVAVSDM KKDFESCLGAKQGF---KGF ---QVALDH---HN-DHK--TFIY---NNSEFSLAHGSVVIAAITSCTNTSNPSVM LGAGLLAKKAVDAGLTVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTC IGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTI RIDFEKEPLGV-NAKGQQVFLKDIWPTRDEIQAVERQFVIPGMFKEVYQKIETMNESWNA LAAP-SDKLYYWNPKSTYIKSPPFFENLTLDL-Q-PPKSIVDAYVLLNLGDSVTTDHISP AGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLN-K- QAPQTIH---LPSGEILDVFDASERYQQAGLPLIILAGKEYGSG SSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYL-PGENADTLGLTGRERYT VSIPE-NLKPRMKVQ--VKTS--LLGTALKCC FGARR---L