At2g01980.1/MSA

>gi|22325422|ref|NP_178307.2|	  1146 residues, 50 /line  SOS1 (SALT OVERLY SENSITIVE 1); sodium:hydrogen antiporter [Arabidopsis thaliana] --MTTVID---ATMAYRFLEEATD

-SSSSSSS-SKLESSPVDAVLFVGMSLV-L--

--GIASRH L--LRGTRVPYTVALLVIGIALGSL-EYGAKHN--LGKIGHGIRIWNEIDPEL--- --LLAVFLPALLFESSFSMEVHQIKRCLGQMVLLAVPGVLISTACLGS LVKV---TFPYE---WDWKTSLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLSTI IEGESLMNDGTAIVVFQLFLKM--AM-GQ-NS-DWSSIIKFLLK---VALGA VGIGLAFGIASVIWLKFIFNDTVIEITLTIAVSYFAYYTAQEWAGASGVLTVMTLG MFYAAFARTAFKGDSQ-KSLHHFWEMVAYIANTLIFILSGVVIAEGILDSD-KIA- --YQGNSWRFLFLLYVYIQLSRVVVVGVLYPLLCRF--G-YGLDWKESIILVWSGL RGAVALALSLSVKQSSG--N---SHISKETGTLF-LFFTGGIVFLTLIVNGSTTQFVLRL LRMDILPAPKKRI-LEYTKYEMLNKALRAFQDLGDD---EELG-PADWPT-VES-- --YISSLKGSEGE--LVH--HPHN---GS---KIG- -SLDPKS-LKDIRM-R FLNGVQATYWEMLDEGRISEVTANILMQSVDEALDQVS--T--- -TLCDW-RGLKPHVN--FPNYYNFL--- -HSKV-VPRKL-

---VTYF-AVERLESACYI- ---SAAFLRAHTIA---RQQL-YDFLGESNIG SIVINES---EKEGEEAKKFLEK-VRSSFPQVLRVVKTKQVTYS VLN---HLLGYIENLEKVGLLEEKE-IAHLHDAVQTGLKKLLRN --PPI--- --VKLPKL SDMITSHP---LS--VALPPAFCE-PLK HSKKEPMKLRGVTLYKEGSK-PTGVWLIFDGIVKWKSK--I-LSNNHS LHPTFSHGSTLGLYEVL-TG-KPYLCDL --ITDSMVL-CFFIDSEKILSL-QSDST--IDDFLWQESALVLL-KLLRPQIFESV AMQELR---ALVST-ESSKLTTYVTGESIEIDCNSIGLL- --LEGFVKPVGIKEE-LISSP-AAL--SPSNGNQ-SFHNSSE--ASGI--MRVSFSQQAT QY-IVETRARAIIFNIGAF-GADRTLHRRPSSLTPPRSSS-SD-QLQRSFRK EHRGLMSWPENIYAK-QQ-QEINK-TTLSLSERAMQLSIFGSMVNVY- --RRSVSFGGIYNNKLQDNLLYKKLPLNP--- AQGLVSAKSESSIVTKKQLETRKHACQL---PLKGE S-STRQNTM-VESSDEEDEDEGIVVR-IDSPSKIVFRN---D-- L >gi|106364303|dbj|BAE95196.1|	  1169 residues, 50 /line  putative Na+/H+ antiporter [Suaeda japonica] --MAASRI---EVPFPFM---LAEDVTSPSSS

-NSTVSAV-LEEESNPTDAVIFFGASLI-L--

--GIACRH F--LRGTRVPYTVALLVIGIGLGSL-EYGTKHG--VGRFGDGIRIWENIDPEL--- --LLAVFLPALLFESSFSMEIHQIKRCIAQMVLLAGPGVLLSTCILGA ALKL---TFPYG---WNWKTSLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLSTI IEGESLMNDGTAIVVYQLFYQM--VL-GR-SF-TWVAIVKFLLQ---VALGA VGMGIVFGAASVLWLGFIFNDTVIEISLTLAVSYVAYFTAQEGADVSGVLTVMTLG MFYAAAARTAFKGESQ-QSLHHFWEMVAYIANTLIFILSGAVIAQGVLSSDNIFE- --NHGIAWGYLFLLYAYVLVGRAIVVGVLFPFLRYF--G-YGLEWREALILIWAGL RGAVALSLSLSVKRSSG--D--PALLSTQTGTLF-VFFTGGIVFLTLIVNGSTTQFLLSS LGMNKLSKAKRRI-LDFTKYEMEKKALDAFGDLGED---EELG-PADWAT-VKR-- --YIKSLNTLDEE--RIH---PHE---ASGTENDG- -YLDPMN-LKDMRV-R LLNGVQAAYWAMLDEGRITQNTANVLMQSVDEALDKVDY-E--- -PLCDW-KGLKSSVQ--FPNYYRFL--- -QGSI-YPKKL-

---VTFF-TVERLESACSI- ---CAAFLRAHRIV---RGQL-HDFIGDSEVS FAIINES---EAEGEEARKFLED-VRITFPQVLRVVKTRQATFA VLQ---HLIHYIESLEKAGILEEKE-MVHLHDAVQTDLKRLLRN --PPT--- --VKLPKV GDLICTHP---FL--GALPEGLRN-RLV GSTKEEVKVRGMTLYKEGGK-PNGIWLISNGVVKWASK--S-SKNKHV LHPTFTHGSTLGLYEVL-IG-KPYFCDM --ITDSVAV-CFFIEAEKIQAVLGSDPA--VEHFFWKESVIVLA-KVLLPRFFENK SMQDMR---MLT-A-ERSTLNTYLRGETIEVPPHSIGFL- --LEGFIKSHSLVEE-LITSP-APL--FPAQGNS-SFLN-QNHNGSGYN-KSTSFSHQGA SY-YVETRARVLLIDMSQS-QPESTLQRRKSSFLL-PEQ-SARNLTNR EHSGLLSWPENQYRS-HQQL--PTG--QEI-E-ESENLSAKAMQLSIYGSMVPSR- --GESFKEAPMRGQSFKGDNLGNPSHVRSYPQVPFSDQ-- ---EQRSLTSVKSEGSTAVRKRLAEEGIKQEL--LPPAHS S-RHPSHAR-DDSSSESGGDEDVIVR-IDSPSKLSFRQ---A-- P >gi|116077879|emb|CAL44986.1|	  1050 residues, 50 /line  putative Na/H antiporter [Cymodocea nodosa] --MAAVED---GALPYRK---LLEEV--

-NGTVTGE-GRSESTPQDGIIFVGVSLV-L--

--GIASRH M--LRGTRVPYTVALLLLGIGLGAL-EFQTSNG--LGKLGSGIRLWSHINPEL--- --LLGVFLPALLFESSFGMEVHQIKKCLAQMILLAGPGVIASTFCLGS LLKL---TFPYN---WDWKTSLLLGGLLSAT--DPVAVVALLKD-LGA-SKKLNTI IEGESLMNDGTAIVVYQLFYDM--VL-GQ-EF-SAGSIIKFLCE---VSLGA VAVGLAFGIVSVLWLHYIFNDTVIEVTLTLAVSYIAFYTSQDAIKVSGVLSVMTLG MFYAVAARTAFKGETH-ESLHHFWELVSYIANTLIFILSGVVIGENVMSDKSSFE- --SDGAKWGYLILLYVYVQLSRATVVGILFPFLRYF--G-YGLGLKEAAILIWSGL RGAVALALSLSVKRAGD--SLESPSLKQDVGTSF-VFFTGGIVLLTLIINGSTTQFLLHF FAMDKLPDAKIRI-LNYTKYEMLNKAMETFDDLGDD---EDLG-PVDWPT-VKK-- --YITCLNDLEGV--QEN---PHT---IS--ESEN- -QLHDMN-LSDTRV-R LLNGVQAAYWEMLEEGRITQTTGILLMQSVDEAMDTVSH-E--- -TLCDW-KALKAHVH--FPKYYKFL--- -QMSR-IPQGL-

---VTYF-TVERLESACYI- ---SAAFLRAHRIA---RRQL-REFIGESEIA TAVINES---EEEGQEARNFLED-VRISFPQVLCAVKAKQVTYS VLK---NLSEYVQTLEKIGLLEEKE-MLQLDDAVQTDLKKLLRK --PPS--- --VVMPKL KDLLDRHP---LL--GVLYKQVQV-PFE KSTKEIMKTEGRTLYREGSK-PKGIWLISSGVFKWAST--T-LSSRQS LHPDFLHGSPLGLYEVL-AG-KRFICDM --VTDSLVH-CFFIKAEKILPLLRSDPE--VEELLWRESSIVIA-KLLLPLVFENL PLQEVQ---GLL-N-ERSRMDTYVSGESIEIPHNSVCIL- --LEGSLESQDAHRS-LIASP-AVL--LPSNVAP-SFLN-LE--SSGT--VPASCCHRGN SY-MVEAIARVVRFEIGAN-ERRSPPQWRQSLCMP-QSV-GPQRLPVR EQCGLLSWPENLQRA-RSHP--QVL--NAYGH-QANNMSARGTGLHNFRSMV

- >gi|119359748|dbj|BAF41924.1|	  1129 residues, 50 /line  Na+/H+ antiporter [Phragmites australis]

MGDPDDAVLFVGVSLV-L--

--GIASRH L--LRGTRVPYTVALLVLGVALGSL-EYGTQHG--LGKLGSGIRIWANINPDL--- --LLAVFLPALLFESSFSMEIHQIKRCMAQMVLLAGPGVIISTFLLGT AVKL---TFPYN---WSWKTSLLLGGLLSAT--DPVAVVALLKE-LGA-SNKLSTI IEGESLMNDGTAIVVYQLFYRM--VL-GR-TF-DAGSIIKFLSQ---VSLGA VALGLAFGIVSVLWLGFIFNDTIIEIALTLAVSYIAFFTAQDSLEVSGVLTVMTLG MFYAAFAKTAFKGDSQ-QSLHHFWEMVAYIANTLIFILSGVVIADGVLQNNVHFE- --RHGTSWGFLVLLYVFVQISRVVVVGVLYPLLRHF--G-YGLDLKEAAILVWSGL RGAVALSLALSVKRTSD--AVQ-PYLKPEVGTMF-VFFTGGIVFLTLILNGSTTQFLLHI LGLDKLSATKLRI-LKYTRYEMLNKALEAFGELRDD---EELG-PADWVT-VKK-- --YITCLHDLGDE--PEH---PHD---VS--DKDD- -RMHTMN-LRDIRV-R LLNGVQAAYWGMLEEGRINQATANILMRSVDEAMDLVSR-Q--- -PLCDW-KGLQSSVQ--FPNYYRFL--- -QMSK-LPRKL-

---ITYF-TVERLESGCYM- ---CAAFLRAHRIA---RRQL-HDFLGDSEVA RIVIDES---NAEGEEARKFLED-VRITFPQVLRVLKTRQVTYS VLT---HLSGYIQNLQKTGLLEEKE-MVHLDDALQTDLKKLKRN --PPL--- --VKMPRV SELLNNHP---LV--GALPAVSRD-LLL SNTKETVRGHGTNLYREGSR-PTGIWLVSIGVVKWTSQ--R-LSSRHS LDPILSHGNTLGLYEVL-IG-KPYICDM --ITDSVVH-CFFIEAEKIEQLRQSDPS--IEVFLWQESALVIA-RLLLPQIFEKM AMHEIR---VLI-A-ERSTMNIYIKGEDIELEQNYIGIL- --LEGFLKTKN--QN-LITPP-GVL--LPSNTDL-NLFG-LE--SSAM--NHIDYCYTAP SY-QVEARARIIFFEIGRVWETQPDLQ-RTVSLLA-QTH-EPPRTLSK EHSGLLSWPESFRKS-RGPHN-VSF--AEMRN-QPGSLSARALQLSMYGSMINDM- --HSGQGQRRQRHRMQATNQKHSSSYPRVPSRPS-- ---NARPLLSVQSEGSNMKRMAAPKEAGE--A--PAPATS AG--QRRRKAMEA-NNSSDDESAGEEVIVR-VDSPSMLSFRQ---PS- K >gi|57117296|gb|AAW33875.1|	  1148 residues, 50 /line  Na+/H+ antiporter [Oryza sativa (japonica cultivar-group)]

---M-DNPEAEPDDAVLFVGVSLV-L--

--GIASRH L--LRGTRVPYTVALLVLGVALGSL-EFGTKHG--MGKLGAGIRIWANINPDL--- --LLAVFLPALLFESSFSMEIHQIKKCMAQMVLLAGPGVLISTFFLGS ALKL---TFPYN---WNWKTSLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLSTI IEGESLMNDGTAIVVYQLFYRM--VL-GR-TF-DAGSIIKFLSE---VSLGA VALGLAFGIASVLWLGFIFNDTIIEIALTLAVSYIAFFTAQDALEVSGVLTVMTLG MFYAAFAKTAFKGDSQ-QSLHHFWEMVAYIANTLIFILSGVVIADGVLENNVHFE- --RHGASWGFLLLLYVFVQISRILVVVILYPLLRHF--G-YGLDLKEATILVWAGL RGAVALSLSLSVKRASD--AVQ-THLKPVDGTMF-VFFTGGIVFLTLIFNGSTTQFLLHL LGMDRLAATKLRI-LNYTKYEMLNKALEAFGDLRDD---EELGPPADWVT-VKK-- --YITCLNDLDDE--PVH---PHA---VS--DRND- -RMHTMN-LRDIRV-R LLNGVQAAYWGMLEEGRITQTTANILMRSVDEAMDLVPT-Q--- -ELCDW-KGLRSNVH--FPNYYRFL--- -QMSR-LPRRL-

---ITYF-TVERLESGCYI- ---CAAFLRAHRIA---RRQL-HDFLGDSEVA RIVIDES---NAEGEEARKFLED-VRVTFPQVLRVLKTRQVTYS VLT---HLSEYIQNLQKTGLLEEKE-MAHLDDALQTDLKKFKRN --PPL--- --VKMPRV SDLLNTHP---LV--GALPAAMRD-PLL SSTKETVKGHGTILYREGSR-PTGIWLVSIGVVKWTSQ--R-LSSRHS LDPILSHGSTLGLYEVL-IG-KPYICDM --ITDSVVH-CFFIEAEKIEQLRQSDPS--IEIFLWQESALVVA-RLLLPMMFEKM ATHELR---VLI-T-ERSTMNIYIKGEEIELEQNFIGIL- --LEGFLKTKN--QT-LITPP-GLL--LPPNADL-NLFG-LE--SSAI--NRIDYCYTAP SY-QVEARARILFVEIGRP-EIEADLQ-RSASLIS-QTL-ELPRTQSK EHSGLLSWPESFRKS-RGAQNGASL--TEIRD-HPASFSARALQLSMYGSMINDM- --KSGQGQGQRRQRHRHTKASSNKAHSSSYPRVPSRSSN- ---TQRPLLSVQSEGANMTTARQAAAAGASLP--PEPEEA GRRRRRQRKAIEEDEDNSSDESAGEEVIVR-VDSPSMLTFRQ---PSS AAD-R >gi|124301345|gb|ABN04857.1|	  1146 residues, 50 /line  salt-overly-sensitive 1 [Thellungiella halophila] --MATVIE---AVMPYRLLEDETG

---S-PEGESSPVDAVLFVGMSLV-L--

--GIASGH L--LRGTRVPYTVALLVIGIALGSL-EYGTHHN--LGKLGHGIRIWNEINPEL--- --LLAVFLPALLFESAFSMEVHQIKRCLGQMVLLAGPGVLISTFCLAS LVKL---TFPYD---WDWKTSLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLSTV IEGESLMNDGTAIVVFQLFLKM--VM-GH-SS-GWSSIITFLIR---VALGA VGIGIAFGIASVLWLKFIFNDTVIEITLTIAVSYFAYYTAQEWAGASGVLTVMTLG MFYAAFARTAFKGDSQ-RSLHHFWEMVAYIANTLIFILSGVVIAEGILDSD-KIA- --YQGSSWGYLFLLYLYIQLSRCVVVGVLYSFLCRV--G-YGLDWKEAIILVWSGL RGAVALSLSLSVKQSSG--N---SFLSTETGTMF-IFFTGGIVFLTLIVNGSTTQFALRL LRMDGLPASKIRI-LDYTKYEMLNKALQAFEDLGDD---EELG-PADWPT-VES-- --YISSLKDSEGE--QVH---PHS---GS--KPG-- -NLDHTS-LKDIRI-R FLNGVQAAYWEMLDEGRISESTANILMRSVDEALDHIST-E--- -PLCDW-RGLKSHVK--FPGYYNFL--- -HSKI-IPGKL-

---VIYF-AVDRLESACYI- ---SAAFLRAHTIA---RQQL-YDFLGESNIG STVIKES---ETEGEEAKEFLEK-VRSSLPQVLRVVKTKQVTYS VLS---HLLDYIQNLEKIGLLEEKE-IAHLHDAVQTGLKKLLRN --PPI--- --VKLPKL SDLITSHP---LS--GALPSAICE-PLK HSKKETMKLRGVTLYKEGSK-PTGVWLIFDGIVKWKSK--G-LSNNHS LHPTFSHGSTLGLYEVL-TG-KPYMCDV --ITDSVVL-CFFINSERILSYVQSDST--IEDFLWKESALVLL-KLLRPQTFEKV PMHELR---ALVSA-ESSKQTTYVSGESIEIDHNSVGLL- --LEGFIKAVGIQEELLIASP-AAL--LHSNENQ-SFRNSSE--ASGI--LRVSFSRQAA RY-SVETRARVIIFNHGAF-GAHRTLQRKPSTLASPRATSSDH-QLKRSASK EHRGLMRWPENIYKA-GQEEEMNG-KTLNLSERAMQLSIFGSTENLY- --KRSVSFGGLNNNKAQDNLSYKKLPSTS--- AQGLFSAKSEGSMATTKQVESRKFVSQL-PPLAASA EGSS---RRETMA-EESSDDE--GEGIIVR-IDSPSTIVFRN---D-- L >gi|124301347|gb|ABN04858.1|	  1151 residues, 50 /line  salt-overly-sensitive 1 [Mesembryanthemum crystallinum] --MAALTD---FQLPLRLAEEVAANATS

--AAAAVA-AESETNPTDAVIFVGVSLV-L--

--GIACRH F--LRGTKVPYTVALLIIGIGLGSL-EYGTKHG--LGRFGDGIRLWEHIDPEL--- --LLAVFLPALLFESSFSMEVHQIKRCIIQMLILAGPGVLISTFCLGS ALKL---SFPYD---WNWKTSLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLSTI IEGESLMNDGTAIVVYQLFFQM--VL-GR-SF-NVAQIIKFLVQ---VSLGA VGIGLAFGVVSVLWLGFIFNDTIIEISLTLAVSYVAYFAAQEAADVSGVLTVMTLG MFYAAAARTAFKGESQ-ESLHHFWEMVAYIANTLIFILSGAVIAEGVLNSGHIFE- --NNGISWGYLVLLYVYVLASRAVVVTVLFPFLRYF--G-YGLEWKEAVILTWSGL RGAVALSLSLSVKRSSG--D--ASLLSAQTGTLF-VFFTGGIVFLTLIVNGSTTQFVLHF LGMDRLSAAKRRI-LEFTKFEMEKRALEAFGDLGED---EELG-PADWPT-VKR-- --YIKSLNS-GGE--QIH---PHD---NS--TSGG- -DLDPMS-LTDIRV-R LLNGVQAAYWVMLDEGRISQSTANILMQSVDEALDSVTH-E--- -PLNDW-NGLKRNVH--FPNYYRFL--- -QGSSMWPRKL-

---VTFF-TVERLESGCYI- ---CAAFLRAHRIA---RRQL-YDFIGESEIA TAVINES---ETEGEEARKFLED-VRITFPEVLRVVKTRQVTHS VLK---HLIDYIHSLEKAGLLEEKE-IHHLHDAVQTDLKRVLRN --PPL--- --VKLPKA KDLVSTHP---LL--GALPATARD-VLV NSTKEVVKVRGLTLYKEGSR-PNGIWLISNGVVKWGSK--S-RVIKHA FHPTFTHGSTLGLYEVL-IG-KPYLCDM --ITDSVVV-CFFVEAEKILSVLGSDFE--MENFLWKESVIGLA-KILLPQIFEKM SMHDLR---LLI---ERSTMNTYLSGENVEVPPHAIGFL- --LEGFIKCHSLHEE-LITSP-AAL--WPAQGNS-SFLS-QD--GTGY--KSTSFYSQGC SY-YVETRARVIVFDINSF-QHDKTLMRRKSSLLL-HDQ-STISLTSR DHGGLVSWPENARPE-REGED---E--EEIDE-HEQNMSARARQLSIYGSMLKEK- --DPLLKTVSFHESVLNKPSSHSLSYPTVPD--A-- ---QGRSLTTVKSEGSHTIRKRLEG-DL-PDIPSVP H---SRRPSQL---PESSDESGGEEDVIVR-IDSPSRLSFRH---A-- P >gi|130917793|gb|ABO32636.1|	  1137 residues, 50 /line  plasma membrane Na+/H+ antiporter [Puccinellia tenuiflora]

---M-EEAGSSPDDAVLLFGVSLV-L--

--GIGSRH L--LRGTRVPYTVALLVLGVALGSL-EYGTKHG--LGKLGAGIRIWAAINPDL--- --LLAVFLPALLFESSFSMEVHQIKKCMAQMVLLAIPGVVLSTVLLGS AVKL---TFPYN---WSWKTSFLFGGLLSAT--DPVAVVALLKD-LGA-SKKLSTI IEGESLMNDGTAIVVCQLFYRM--VL-GT-TF-DAGSIIKFLTQ---VSLGA VALGLAFGIASVLWLGFIFNDTIIEISLTLAVSYIAFFTAQDAFEASGVLAVMTLG MFYAAFAKTAFKGDSQ-ESLHHFWEMVAYIANTLIFILSGVVIADGVLQDNIHFE- --RHGASWGFPLLLYVFVLTGRAVVVTVLYPLLRHF--G-YGMDVKEATVLVWSGL RGAVALSLSLSVKRASD--ADQ-PNLKSEVGTMF-VFFTGGIVFLTLIVNGSTTQFLLHL LGLGKLSATKLRV-LKYTRYEMLNKAKEAFGDLRDD---EELG-PADWIT-VKK-- --YITCLNNLEDE--QAH---PHD---AP--DKDE- -SVHTMN-LRDTRV-R LLNGVQAAYWGMLEEGRITQATANILMRSVDEAMDLVST-Q--- -SLCDW-KGLRSNVH--LPKYYRFL--- -QMSR-LPRRV-

---VTYF-TVERLELGCYI- ---CAAFLRAHRIA---RRQL-HDFLGDSEIA RIVIDES---TAAGEEAKKFLED-VRLTFPQVLLALKTRQVTYA VLT---HLSEYIQDLGKTGLLEEKE-MVHLDDALQTDLRKLKRN --PPL--- --VKMPRA SEILNTHP---LV--GALPAAVRD-PLL SNTEETIKVHGTILYSEGSR-PTGIWLVSTGIVKWTSQ--R-LSTRHS LDPILSHGSTLGLYEAL-VG-KPYICDI --ITESVVH-CFFIEAETIEQLRQSDPS--IEDFLWQESALVIA-RIFLPQIFEKM AMREMR---VLI-S-ERSTMNIYIKGEDIELGPNYVCIL- --LEGFLQM-N--QT-LITPP-AVL--LPSNTDL-NVFG-LQ--SSAM--NHIDYCYTAP SY-QVTARARAILFDIRRP-EAESDLQ-RSASLLS-PNL-GPPRTQSK EHIGLLRWPQSFHHRSRGPGN-PSL--AEIGK-QPGSFSASALQVSMYGTMMDDE- -MHTA--QPRPRPDRVEANQKHSASYPKVPSRSLS- ---NTRPLLSVRSEGSNMMKRKSAPAPAHAPALD---PFPP-LA GGR---HHRAITE-GDLSSDESAGEEVIVR-VDSPSMLAFQP---RP- --QGN >gi|37499122|gb|AAQ91618.1|	  1142 residues, 50 /line  putative plasma membrane Na+/H+ antiporter [Triticum aestivum]

---MET-G-EAGSPSPDDAVLFFGVALV-L--

--GIASRH L--LRGTRVPYTVALLVLGVALGGL-EYGTKHG--LGKLGAGIRIWSAINPDL--- --LLAVFLPALLFESSFSMEVHQIKKCMAQMVLLAVPGVVISTVLLGA AVKL---TFPYD---WNWKTSFLFSGLLSAT--DPVAVVALLKD-LGA-SKKLSTI IEGESLMNDGTAIVVYQLFYRM--VL-GK-TF-DAGSIIKFLSQ---VSLGA VALGLAFGIASVLWLGFIFNDTIIEISLTLAVSYIAFFTAQDALEVSGVLAVMTLG MFYAAFAKTAFKGDSQ-QSLHHFWEMVAYIANTLIFILSGVVIADGVLQDNIHFE- --RHGTSWGFLVLLYVFVQISRAVVVGVLYPLLRHF--G-YGMDIKEATVLVWSGL RGAVALSLSLSVKRASD--SVQ-TYLKPEVGTMF-VFFTGGIVFLTLILNGSTTQFLLHL LGLGKLSATKLRV-LKYTQYEMLNKALEAFGDLRDD---EELG-PVDWVN-VKK-- --YITCLNNLEDE--QAH---PHD---VP--DKDD- -HIHTMN-LKDTRV-R LLNGVQAAYWGMLEEGRITQSTANILMRSVDEAMDLVSS-Q--- -SLCDW-KGLRSNVH--FPNYYRFL--- -QMSR-LPRRL-

---VTYF-TVERLELGCYI- ---CAAFLRAHRIA---RRQL-HDFLGDSEIA RIVIDES---TAVGEGAKKFLED-VRVTFPQVLRALKTRQVTYA VLT---HLSEYIQDLGKTGLLEEKE-IVHLDDALQTDLKKLKRN --PPL--- --VKMPRV RELLNTHP---LV--GALSADVRD-PLL SNTKETIKVHGTILYREGSR-RTGIWLVSTGIVKWTSR--R-LCTRHS LDPILSHGSTLGLYEAL-TG-KPYICDI --ITESVVH-CFFIEAEKIEQLRQSDPS--IEDFMWQESALVIA-RILLPQIFEKM AMREMR---VLI-S-ERSSMNVYIKGEAIELGHNNVGIL- --LEGFLKTEN--RT-LITAP-AVL--LPSNTDL-NLFG-LQ--SSAM--NQIDYCYTAP SY-QVEARARAIIFEIGRL-DIEADLQ-RSASLLS-STL-GPSRTQSK EHVGLLRWPESFRRS-SGPGN-ASL--AEIRG-QPGSFSARALQVSMYGSMTDG-- -MHRA--RRQPRLAHVEGNQKHSVSYPKVPSRA-A- ---DTRPLLSVRSEGSNAMKRKSAPAPAIAPALA---PFPPPLA EGQ---QRRAVGE-DDDSSDESVGEEVIVR-VDSPSMLSFNP---PSG PPRGS >gi|65432047|gb|AAY42598.1|	  1110 residues, 50 /line  SOS1 [Lolium perenne]

---GSTSPRASPQS--

IHRS F--LRSKFVIFFCFLSSPRRS-EYGTKHG--LGKLGAGIRIWAGINPDL--- --LLAVFLPALLFESSFSMEVHQIKKCMAQMVLLAVPGVVISTVLLGT AVKL---TFPYD---WNWKTSFLFSGLLSAT--DPVAVVALLKD-LGA-SKKLSTI IEGESLMNDGTAIVVYQLFYRM--VL-GT-TF-DAGSIIKFLSE---VSLGA VALGLAFGIASVLWLGFIFNDTIIEISLTLAVSYIAFFTAQDALEVSGVLAVMTLG MFYAAFAKTAFKGDSQ-ESLHHFWEMIAYIANTLIFILSGVVIADGVLQDNIHFE- --RHGASWGFLLLLYVFVQLSRAVVVIVLYPLLRHF--G-YGMDVKKATVLVWSGL RGAVALSLSLSVKRASD--AVQ-LYLKPEVGTMF-VFFTGGIVFLTLIVNGSTTQFLLHL LGLGKLSATKLRV-LKYTRYEMLNKALEAFGDLRDD---EELG-PADWIT-VKK-- --YITCLNNLEDE--QAH---PHD---VP--DKDE- -SVHTMN-LKDTRV-R LLNGVQAAYWGMLEEGRITQSTANILMRSVDEAMDLVSG-Q--- -SLCDW-KGLRSNVH--FPNYYRFL--- -QMSR-LPRRL-

---VTYF-TVERLQLGCYI- ---CAAFLRAHRIA---RRQL-HDFLGDSEVA RIVVDES---TAAGEEAKKFLED-VRVTLPQVLRALKTRQVTYA VLT---HLSEYIQDLGKTGLLEEKE-MAHLDDALQTDLKKLKRN --PPL--- --VKMPRV SELLNTHP---LV--GALPAAVRD-PLS SNTKETIKVHGTVLYTEGSR-PTGIWLVSTGIVKWTSQ--R-LSTRHS LDPIFSHGSTLGLYEAL-VG-KPYICDI --ITESVVH-CFFIEAEKIEQLRQSDPS--IEDFMWQESALVIA-RIFSPSDIEKM AMHEMR---VLI-S-ERSMLNIYIKGEDIEPGHNYVGIL- --LEGFLKM-N--NH-LITPP-AVL--LPSNTDL-NVFG-LQ--SSVM--NHIDYCYTAT SY-QVEARARAILFEIRRP-EAESDLQ-RSASLLS-PTL-GPSRTQSK EHVGLVRWPESFRRS-RGPGN-PSL--VD--I-GSQSFSARALQVSMYGSMMDDM- --HPA--QRRQRPHPVKANQEHSASYPKVPSRVMS- ---NSRPLLSVQSEGSNLMNRKSAPAPAIA---PFPP--- -RR---QRRAIAE-EDNSSDESVEEEIIVR-VDSPSMFTFHP---PS- --QGS >gi|66765937|emb|CAG30524.1|	  1151 residues, 50 /line  putative plasmalemma Na+/H+ antiporter [Solanum lycopersicum] --MELLVETRPFRIVEESIS

-A-ESSDPTNAVIFVGISLL-L--

--GIGCRH L--LRGTRVPYSVALLVLGIGLGAL-EYGTHHG--LGRIGDGIRIWANIDPDL--- --LLAVSFPALLFESAFSMEIHQIKRCAVQMLLLAGPGVLISTFFLGA ALKI---AFPYN---WSWSTSLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLGTI IEGESLMNDGTAIVVYQLLLRM--VT-GW-TF-NWGAVIKFLVQ---VSLGA VGFGIAFGIASVLWLGFIFNDTVIEISLTLAVSYVAYFTAQQGADVSGVLTVMTLG MFYSAVAKTAFKGESH-QSLHHFWEMVSYIANTLIFILSGVVIAEGILAGDNIFK- --IYDNSWGYLILLYVLILVSRAVVVGVLYPFLRYF--G-YGLDLKEAFILVWGGL RGAVALSLSLSVKRSSD--G--SQYISSDTGTLF-VFLTGGVVFLTLIINGSTTQFALHY LGMDKLSAAKKRI-LNYTKYEMLNKALEAFGDLGDD---EELG-PADWPT-VKR-- --YITSLNDVEGE--PVH---PHT---SS--GNDD- -NVDHMH-LEDIRI-R LLNGVQAAYWEMLNEGRIPQTIANLLMQSVEEANDVVSH-E--- -PLCDW-KGLKSYVN--IPNYYKFL--- -QTSF-VHRKL-

---VTYF-TVERLESACYI- ---CAGFLRAHRTA---RQQL-NEFIGESEIA SLVIKES---EEEGEDARKFLEE-VRVSFPQVLRVVKTRQVTYA VLN---HLIDYVHNLEKIGILEEKE-MAHLHDAVQTDLKRLVRN --PPL--- --VKFPKI RDLISVNP---LL--GALPPTVRE-TLI GSTKEIMKLRGATLYEEGSK-ATRVWLISNGVVKWSSK--S-TSNIHL LHPTFSHGSTLGLYEVL-VG-KPYICDI --ITDSVAL-CFSVDNERILTALRSDPA--VEDFFWQESALVLA-KVLLPQMFETT KMQDMR---TLV-A-ERSTMSIYIRGESFELPHHSIGFL- --LEGFVKSHGSHEG-LLSAP-APL--LPLALEQQSFHN-TE--ASGV--HAASFSHQPS QY-QVETRARVIMFDIAGF-LSGRGLQRRSSSLLS-HSIDHPSRSFSR ELGGLMSWPENTYKA-MQH--RQDV--ERTGQ-QETNMSTRAMQLNIFGSMISDT- -RSRSRSFPGISAAKTSHSQSYPEVRS---D- ---GVQTLVSVRSEGSTTLRKKAQVQGENKDMS-IQLPSA PI---EESDTR---EYSSDDSGGEDEHLIR-IDSGRPSFPQW---IAE EDKTS >gi|99029169|gb|ABF60872.1|	  1145 residues, 50 /line  Na+/H+ antiporter [Populus euphratica] --MGSAIEKG-VGLPYRILESSSS

-SSA-ASDEWNPTDTVLFFGFSLL-L--

--GIACRH L--LRGTRVPYTVALLVVGIALGSL-EYGTSHK--LGRIGDGIRLWAHIDPDL--- --LLAVFLPALLFESSFSMEVHQIKRCMGQMLLLAVPGVLISTCCLGC ALKL---IFPYN---WSWTTSLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLSTI IEGESLMNDGTAIVVYQLFYRM--VL-GE-SF-NSGAIIKFLTQ---VSLGA VGIGIAFGIASFLWLGFIFNDTVIEIALTLAVSYVTYFTAQEGAAVSGVLAVMTLG MFYAAVARTAFKGDGQ-QSLHHFWEMVAYIANTLIFILSGVVIAEGVLSSGNTFH- --RHAHTWGYLFLLYAFVLLSRFIVVGVLYPILRYF--G-YGLEWKEAIIVIWSGL RGAVALSLSLSVKRTSD--S--SVYLSSDTGTLF-VFFTGGIVFLTLIVNGSTTQFILHL LDMDKLSATKKRL-LNFTKYEMLNKALEAFGDLGED---EELG-PVDWPT-VKR-- --YIPSLNSLEGS--CEH---PHG---AS--EADN- -NLDPTN-LKDIRI-R LLNGVQAAYWGMLDEGRITQTTANILMQSVDEAIDLASH-E--- -PLCDW-KGLQSNVH--FPNYYKFL--- -QASI-FPQKM-

---VTYF-TVERLESACYI- ---CAAFLRAHRIA---RRQL-HDFIGDSGIA SLVINES---NAEGEEARKFLED-VRVTFPQVLRVVKTRQATYS VLN---HLIDYVQNLEKVGLLEEKE-MLHLHDAVQTDLKRFLRN --PPL--- --VMLPKI TDLISVHP---LL--EALPSIVRE-PLE RSSKEIMKPRGVPLYKEGSK-PNGVWLISSGVVKWTSK--S-VRSKHS LHPTFTHGSTLGLYELL-VG-KRCICDI --ITDSVVF-CFFIESENMLSLLGSDPA--IEDFLWQESAIVIA-KLLLPQVFEKM PMQELR---ALV-A-ERSVMTTYLRGETIEIPHHSIGFL- --LEGFIKAHGFQDE-LIASP-AVL--LPPQGNQ-SFQK-IG--MSGA--QAASFSHQGS RY-QVEARARVIIFDIAAF-EADGALRRGSSSLVL-G--DHPHRYFTR EHGGLMSWPENFYKP-RER--EQNG--VGTSR-SENSLSVRAMQLSIFGSMV-DM- -RRHAHSFSG-SQVKRSHSLSV--LRN---A- ---SYQQVRVPSDEATYA-RKSLEVRKLIGKTH-APPPQS TG--TNETRII---DNYSDESDAEDELVVR-IDSPRTLSFHH---A-- S >gi|27525521|emb|CAD20320.1|	  1145 residues, 50 /line  putative Na/H antiporter [Cymodocea nodosa] --MAAVE-HG--PLSYRM---FLEEV--

-NGTVTGE-VKSESSPQDGIIFVGVSLV-L--

--GIASRH V--LRGTRVPYTVALLLLGVGLGAL-EYGTSHG--LGKLGSGIRIWANINPDL--- --LLGVFLPALLFESSFAMEVHQIKRCIVQMILLAGPGVLTSTFCLGS LLKL---TFPYN---WDWKTSLLLGGLLSAT--DPVAVVALLKD-LGA-SKKLSTI IEGESLMNDGTAIVVYQLFYRM--VL-GE-KF-GVGSIIKFLSE---VPLGA VAVGLAFGIVSVLWLGFIFNDTIIEITITLAVSYIAFYTSQEAIELSGVLTVMTVG MFYAAAARTAFKGESQ-ESLHHFWEMVAYIANTLIFILSGVVIGESVMRNESNFE- --SDGATWGYLILLYAYVQLSRVAVVAILFPLLRYF--G-YGLEFKEALILIWAGL RGAVALSLSLSVKRASD--SLDSPSLKQEVGTLF-VFFTGGIVFLTLIINGSTTQFLLHF LAMDKLSAAKIRI-LNYTKYEMLNKAIEAFEDLGED---EELG-PADWPT-VKK-- --YITCLNDLEGE--KEH---PHT---IT--ESEN- -HLHHIN-LSDTRV-R LLNGVQAAYWEMLDEGRITQTTGILLMQSVDEAMDTVSH-E--- -PLCDW-KALKSYVH--FPKYYKFL--- -QMSR-IPQRL-

---VTYF-TVERLESACYI- ---SAAFLRAHRTA---RRQL-HEFIGESEIA AAVINES---NAEGEDARNFLED-VRISFPQVLRAVKTKQVTYS VLK---HLSEYVQTLEKVGLLEEKE-MLHLDDAVQTDLKKLLRN --PPL--- --VKMPKV RELLDTHP---LL--GVLPKQVRV-PLE NSTKETMKIKGTTLYKEGSK-PNGIWLISNGVVKWASK--T-LSNRQS LHPTFLHGSTLGLYEVL-VG-KPFICDM --ITDSLVH-CFFIEAEKIVPLLRSDPD--IEEFLWQESSIVIA-KLLLPPVFEKL SLQEVR---GLI-A-ERSRMNIYISGEFIEIPHNSVCIL- --LEGFLKTQDAHKS-LIASP-AVL--LPSNVEL-SFLS-LE--SSGI--AAASFCHRGN SY-MAEARARVILFEIGAT-EPPSPLQRRQSSWMS-HSI-EPQKL--Q EHGGLMSWPENLQRA-RSH---QIL--KDSDH-HANNMSTRAMELNIFGSMVEGT- --H--KHHAGVPKTSLDFSKSYHRIPSET--- ---SPLPLVSTRSEGESLGKRLGQREKPK---LL---PPPPKPV TGA---SESKPAE-DNSSDESGAEEEIIVR-IDSPSHID- I >gi|33352144|emb|CAD91921.1|	  1153 residues, 50 /line  putative Na/H antiporter [Physcomitrella patens] ME---SMSTV--

-APAPSTA-ATEEVGPEVAILFVGVALF-L--

--GMVSRH L--FKGSRIPYTVVLLLLGIGIGGL-EYGVKN---LGVLGDSIRMWSNIDPDL--- --ILFLFLPALLFESSFAMDFHQIKRCFFQMLLLAAPGVLISTFLLGV ATVK---VFPYN---WNWSTGLLLGGLLSAT--DPVAVVALLKE-LGA-SKKLSTL IEGESLMNDGTAIVVFRLFLQM--VL-GK-HF-SAGDVVSFLSR---VVFGA VALGLLFGIVSVIWVGRVFNDTVIEITLTLTASYMAFFVAEESASVSGVLTVMTVG IFFTAFARTAFTGESA-QSMHHFWEMISYIANTLVFLLSGVVIAESILRSQDKIQ- GRDWGYLLLLYLFVQISRAMVVGLLYPGLKYF--G-YGINWKEAIVLIWAGL RGAVALSLSLSVAQVGQHDPTQNTYLSKLTEARF-VFFTGGVVLLTLIINGSTTQFLLLF LKMDTITETKSRM-LEFAKYEMYSKALEAFGELGDD---EELG-PADWNT-IRK-- --YVSCLSYEENK--PTH---PHGPPSFA--LPDG- -EYAKQQ-MTDTRT-R FLNGLQAAYWNMLDEGRITQTAALILMQSIDEALDKVKH-HT-- -ALQDW-EGLRPHIH--FPGYLKYFS-- ---WRSTSV-LPRRA-

---STYF-LIQQLELACYI- ---AAAFLRAHRMT---RNHL-RDFIGESEVT EAVIQES---EAQAQHARLFLED-VRLSFPQVLRAVKAKQVTHA ILL---HLTTYVESLENAGLFESKE-AVHLHDAVQIDLKKLLRD --PPI--- --VEMPSA EQTLQNQP---FI--GAMPTSVQK-PLL DVSKEYMKLQGSVIYREDMK-SDGIWLITNGVVKWSKK--A-VGGQRL RQPTFSFGSTLGLYEVL-TG-KPYLCDV --VADSVVH-CFFVERSRILFIQKERAD--LEDFLWQESALAVA-KIVLGPQFDMA TLQDIR---ALV-M-EGSSMRIFLRGEVFELRHKEMGLL- --LEGFVRQENST-E-LITAP-AGL--TAK--ILL-PS--PTGS--WSNISLQQPT VF-HAEARSRVLLFESSKV-GEILSQGSSQLLAVP-RKT-SRSMLRLSSKTSTNTR TKVDRHSSHNEIRIA-SDH--SIPIAQAWG-SGSSC-VPDKYTAKALEISVFGSEVDVR- --DKRRADEIPLDAQSRFTQSHSNLVKRV--- ---SLMMQERFDNKQTSMPKRKIASQEN--MTVPMS LLP---HQSEPKP-DDSSDDS-DKEEHIVR-IDSPSFLFHNS---RR- ---EL >gi|109032998|ref|XP_001103513.1|	  1219 residues, 50 /line  PREDICTED: similar to sperm-specific sodium proton exchanger isoform 3 [Macaca mulatta] --MDDDTDIVSDIN---LQKNVSSTWLE YFRS-LFFSA--

PDDLPEIILTLSLIST-I--

--GAFLNL H--LKDFPIPLPVMLFLLGCGFEVL-SF-TSLR--VQRYANAIQ---WMSPDL--- --LFCIFAPVIFFTTAFDMDTYMLQKLFWQILLITIPGFLVNYILVLW YLAA---VNKLH---LKPTPWLLFSAILVSS--DPMLTAAAVRD-LGL-SRSLISL INGESLMTSVISLIIFTSIMDF--DK-EQ-QNKRNHTIARYIVGEFFS---NIIAS FLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICE-LLGMSGIFTLAIVG LLLNS---TSFKAGVE-ALLLEFWNFLSRVAFLMVFTFFGLLIPAHTYLY-- --VKFADIYYSLNIYFTLIVLRLVTLLLMSPALSRV--G-HEFSWRWVFTMIWSET KGMPNINMALLLAYSD--LYFGSDKEKSQI-LFHGVLVCLITLIVNRFVLPTAVTI LGLRDATSTKYKS-VCCTFQHFQELTKSVASVLKFD---KDLA-NADWNM-IEK-- --AIILENPYMLNQEET--TEQ--QKVKCPHC---NK--EIDE- -ILNNEA-MELANR-R LLSAQMASYQRQYRNEILSQSAVQVLVGAAGSFGEKKGK-CMRLETIKNYSESQK- --TITFTRKLLLNWVYNTRKEKV--GPSKYFFFHLCHTIVFTEEFEYVGYLVILMNIFPF VISWISRLNA-IYRRELKHTNYCFLTLYV-LEALLKIAAM R-KDFFSHTWNLFELAITLTGILYAILTEIEA--IKY-IF AVTEIIVFIKLVQFIRILRIFKLIAPKVLQIIDKR-VSQQKTFWYGI- ---LKGYVQGEADV---MTII-DQITSSKQIK QILLKRV---IRNMKHATKELGY-LEYDHPEIAVTVKTKEEINV MLN---MAREILKAFGLKGIIHKIE-SAQISKLIMAKKKEMLES --KSI--- --IRPLTV EEVLYHIQ---WL--DK-NQDHIN-FIQ EKAKVVTFDCGNGIFEEGDE-PQGIYIIISGMVKLERSKPGLGIDQMV-ESKE-KDFLII DTDYMLSGEIIGEINCL-TN-EPMKYSA --TCETVVETCFIPKTHLYDAFKQCSPL--IEHKMWLKIGLAITARKIREHLSYED WNYKMQ---LKLSN-IYIEDIPMTTKTDIYDENVIYVIL- --IHGAVEDCQLRK---FYRA-PFL--IPITCHQIQ GI-EDFTKVVIIQTPTNMKA---FRWNIRKFIPKHKSSLT --PGLMR-STETLEAGIQGE-TKTNVK- -EDGAHSTATARSPQ- ---PCSLLWTKFNCKKSL---RINLGKSGK---SETVMKT EACINTV---AMRGVL L >gi|119879464|ref|XP_615728.3|	  1262 residues, 50 /line  PREDICTED: similar to sperm-specific sodium proton exchanger [Bos taurus] --MGAGQGRGLEQVTVNE---VAVGCGCFWMN ELAT-FHLSLTYYIILLLK---LWMALRGNHTVAVANLRCMEQS

REQGRAHS-SEEILGRQQTAYFHSVYIF-F--

--AALLNQ H--LKDFPIPLPVILFLLGCSFEML-SF-TSDK--VQEYADAIQ---WMDSHL--- --FFNLFTPVIIFSVAFDMDVYLLHKLFWQIVFITVPGFLINYTLILW YLAS---VNKLL---LKTTPWLLFSAILVSL--DPMLTSSAIKD-LGL-SRSLVSL INGESLMTSVMSLITFTVIVNI--DL-SL-HKNTIQSLAYIIMREIWL---HLIVS FSFGIVSSKLIQLWMSTVFGEDVNHISLSFSFLYLIFYICE-LTEMSGTFTLVIMG LFLNS---TNFKPGVE-ALILEFWNCLSFVAFLMVFTFTGLLIPAHTYLY-- --ISFSDIYYSLNIYLTLIMFRLLVFLLLSPLLSRL--G-HGFSWRWAFIMVWSEM KGTPNINLALLLAYFE--NSYGSEREKSQI-LFHGVSVSLISLIVNRFILPMAVTK LGLRDVTSTKYKS-LYYTFQHFQELTKSVASALKFD---RDLA-NADWNI-VEK-- --TIILQNPYALGQGET--KEH--QKVKCQHC---NK--EIDD- -NLNIEA-MELANR-R LLSAQIASYQRQYRSETLSQSAIQVLVGAAGSFGEKMVE-YMNAETIKNYSESKK- --ILVFTRKVLLNWVYNTKKEKG--IPSRHCFLRACHKIVFTDEFEYIGYLVILMNMFPI IISCISVLND-IYETELAYANYSFLAFYI-MEALLKIAAM R-KEYFFHAWNLFELTITLVGIIDVMLIETNS--INYYIF DLVQIVIIMKIVRFLRILRILKLVTPRLLQILDKR-MSHQLSFRYAI- ---LKGYVQGEADI---MTII-DKIASSKQVK QMLLRRV---TKNTGHAMKELGY-LEYDHPEIAVTMKTKEEINV MLS---LAREIVKVFRLKGILHKIE-GSEINKIIMAKKRDILDF --QPT--- --YKPLTV EEALYHIP---WL--DK-DEEHIS-FIQ ERSRVVTFDCGNDIFEEGDE-PKGIYVIISGMVKLQRSKPGLGIDQIIWESEE-KDYQIT YTDFVISGAVIGELNCL-TN-APMKYSA --TCKTVVETCFIPKNHLYEAFEQFYPH--IEYRMWLKLGLSITAKKIREHLSYED WNYKMQ---LKLSN-IYVKDIPKNTKTDIYDETVIYVIL- --IHGAVEDCQLRK---AYKA-PFL--IPITCHQIQ GT-EDFTKVTIVQTSIYSKR---FRWNTRKYIASHKPADP --TTSGA-ESRRCEYPFPEE-TRTQFEAG--- -ESGTRENLSQEETH- ---TQNQEPTKSTAKIMM---DKSIYGNAS---NKPKRKS EMFDKAV- - >gi|34535281|dbj|BAC87265.1|	  1177 residues, 50 /line  unnamed protein product [Homo sapiens] -MAG IFKE-FFFST--

-EDLPEVILTLSLISS-I--

--GAFLNR H--LEDFPIPVPVILFLLGCSFEVL-SF-TSSQ--VQRYANAIQ---WISPDL--- --FFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILVLW HLAS---VNQLL---LKPTQWLLFSAILVSS--DPMLTAAAVRD-LGL-SRSLISL INGESLMTSVISLITFTSIMDF--DQ-RL-QSKRNHTLAEEIVGGICS---YIIAS FLFGILSSKLIQFWMSTVFGDDVNHISLIFSILYLIFYICE-LVGMSGIFTLAIVG LLLNS---TSFKAAVEETLLLEFWTFLSRIAFLMVFTFFGLLIPAHTYLY-- --IEFVDIYYSLNIYLTLIVLRFLTLLLMSPVLSRV--G-HEFSWRWVFIMVCSEM KGMPNINMALLLAYSD--LYFGSDKEKSQI-LFHGVLVCLITLVVNRFILPVAVAI LGLRDATSTKYKS-VCCTFQHFQELTKSAASALKFD---KDLA-NADWNM-IEK-- --AITLENPYMLNEEET--TEH--QKVKCPHC---NK--EIDE- -IFNTEA-MELANR-R LLSAQIASYQRQYRNEILSQSAVQVLVGAAESFGEKKGK-CMSLDTIKNYSESQK- --TVTFARKLLLNWVYNTRKEKE--GPSKYFFFRICHTIVFTEEFEHVGYLVILMNIFPF IISWISQLNV-IYHSELKHTNYCFLTLYI-LEALLKIAAM R-KDFFSHAWNIFELAITLIGILHVILIEIDT--IKY-IF NEIEVIVFIKVVQFFRILRIFKLIAPKLLKIIDKR-MSHQKTFWYGI- ---LKGYVQGEADI---MTII-DQITISKQIK QMLLKQV---IRNMDHATKELGY-LEYDHPEIAVTVKTKEEINV MLN---MATEILKAFSLKGIISKTE-GAGINKLIMAKKKEVLDS --QSI--- --IRPLTV EEVLYHIP---WL--DK-NKDYIN-FIQ EKAKVVTFDCGNDIFEEGDE-PKGIYIIISGMVKLEKSKPGLGIDQMV-ESKE-KDFPII DTDYMLSGEIIGEINCL-TN-EPMKYSA --TCKTVVETCFIPKTHLYDAFEQCSPL--IKQKMWLKLGLAITARKIREHLSYED WNYNMQ---LKLSN-IYVVDIPMSTKTDIYDENLIYVIL- --IHGAVEDCLLRK---TYRA-PFL--IPITCHQIQ SI-EDFTKVVIIQTPINMKT---FRRNIRKFVPKHKSYLT --PGLIG-SVGTLEEGIQEE---RNVK- -EDGAHSAATARSPQ- ---PCSLLGTKFNCKESP---RINLRKVRK--

E >gi|37674259|ref|NP_932774.1|	  1120 residues, 50 /line  solute carrier family 9, isoform 10 [Mus musculus]

---M H--LKDFPIPLPVILFLIGCCFEIL-SF-ASTQ--IQIYADAIQ---WMDPDI--- --FFGIFTPVIIFNVAFDMDIYMLQKLFWQILVITIPGFLINYTLILW YLQS---VNKLS---LKTVPWLLFSAVLISS--DPMLTSASIRD-LGL-SRSLTNL INGESLLTSVLSLVIYSGVVHI--RF-KS-K-SVNHTLAHKVMSTAWS---YIVES FITGIVFTKVIQLWMATIFGDDVNHITLIFSVLYLIFYVCE-LVGMSGIFTLATIG LFLNS---TSFKPGVE-AFLLEFWNCLSFIGFLMVFTFIGLLIPAHTYLH-- --ISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRL--G-HGFSWRWAFIMVWSEM KGTPNINMALLLAYSD--ISLGSERERSQI-LFHGVSVCVITLIVNRFILPMAVTK LGLRDVTSTKYKS-VYYTFQHFQELTKSTAMALKFD---KDLA-NADWNM-VDN-- --AIILQNPYALNQEEI--TEH--QKVKCPDC---TK--EIDE- -TLNIEA-MELTNR-R LLSAQIASYQRQYRNEVLSQSAVQVLVGAAGSFGEKKGE-YMSPENIKNFSESKK- --LLSFLRKLLLNWVYNTKKDKG--VPSRYMFLHACHRIVFTNEFEYTGYLVVLMSTYPM IICWISRLKD-IYDNEIKCANYYFLAFYI-LEALLKVAAM R-KEFFSHTWLLFELGITLVGILDIILIETDS--ISY-NF DLTETVVFMNVIRLLRILRILKLVTPKLLQIIDKR-MSQQISFRYSI- ---LKGYVQGEMDV---LNII-DQIASSKQTK QILLKRV---MRNMEHAMKELGY-LEYDHPEIAVTMKTKEEINV MLN---MAREIVKTFRSKGIIHKVE-GTEINKLIMAKKIQVLDL --QSV--- --IQPFNV EEAPCNIP---WL--SE-DPEAIT-FIQ EKAKVVTFDCGNNIFEEGDE-PEGIYVIISGMVKLKRSKPHLEMERVSAESEI-KIHPLP HTEYLLSGEIIGELNCL-TK-ERMQYSA --TCKTVVETYFIPISHLYEGFEKRCPN--MKHKMWQKIGLAITAQKIREHLSFED WNYKLQ---LKLCN-AFIRDIPKSMKTDIYDETVTHVVL- --IHGSAEDCQLRK---IYKA-PFL--IPVTCHQIQ GM-EDFTKVMIIQTSIAVRK---FRWNVRKFIPPRRISMK --PDSERESFETLDETSEED --NGKKENQENEELI-

---EENIN I >gi|74002660|ref|XP_535739.2|	  1227 residues, 50 /line  PREDICTED: similar to sperm-specific sodium proton exchanger [Canis familiaris]

-MYF-F--

--AAFLNL H--LKDFPIPLPVILFLIGCSFEIL-SF-TSEQ--VQAYADAIQ---WMSPKL--- --VFDMFTPIIIFNVAFDMDVYMLQKLFWQILLITIPGFLMNYTFILW YLAS---ANKLF---LKNTPWLLFSAILVSS--DPMLTAAAIRD-LGL-SRSLVNL INGESLMTSIMSLIIFSGIEEI--NV-NL-QK-KNHSITLDILLELWF---YFLAS FLFGILSSKLIQLWMSTVFGEDVNHISLSSSILYFIFFICE-IVGMSGIFTLAIMG LFLNS---TSFKPGVE-VLLLEFWNCLSFVAFLMVFTFIGLLIPAHTYLY-- --VSFYDIYYSLNIYFTLIVLRLLVFLLLSPLLSRF--G-HGFSWRWAFIMVWSEM KGTPNINMALLLAYSD--LSFGSEREKSQI-LFHGVSVCLVTLIVNRFILPIAVSK LGLHDVTSTKYKS-LHCTFQHFQELTKSAASALKFD---KDLA-NADWNM-VEK-- --AIRLQNPYALSQGDT--TEH--QKVKCLDC---NR--EIDE- -TLNIEA-MELANR-R LLSAQIASYQRQYRNETLSQSAAQVLVGAAGSFGEKKEK-YMSPETIKHYSESKK- --LLAFIRKVLLNWVYNTKKEKG--IPSRYYFLRVCHKIVFTDEFEYVGYLVTLMNMFPI IISWIPKLSD-IYEHELRHSNYSFLVLYI-MEALLKMAAM R-KEYFLHAWNVFELVITLVGIIDIILIETNS--ITY-TF DFILTVVFIKIVRFLRILRILKLITPKLLQIIDQK-MSHQQSFQYAI- ---LKGYVQGEADI---MTII-DQISTSKHVK QVLLRRI---TKNTGNAMKELGY-LEYDHPEIAVTMKTKEEINV MLN---LAREIVRVFKSKGIIHKIE-STEINKLIMAKKKEILDF --QPV--- --IKPLTV VEALHHIP---WL--DK-DKEYIT-FIQ KRARIVTFDCGNDIFEEGDE-PKGIYIIISGMVKLQRSKPSFGIDQM--ESEE-KDYQMN YTDFLISGEIIGELNCL-TN-KPMTYSA --TCKTVVETCFIPKNYLYEAFEQCSPH--IEYKMWLKLGLSITAKKIREHLSYED WNYKMQ---LKLCN-VSVKDIPKNIKTGIYDETVIYVIL- --IHGAVEDCQLRK---AYKA-PSL--IPITCYQVQ GT-EDFTKVMIVQTSVDLKN---FRWNTRKYVPSRKPSLPTCGSRTLK KYPGLRKIKAANREHPGKEMSSAPTQDS-ADQSSS- -EDLCYTLINHSVLG- ---GKSSGISAERCYENISPKTETPRESLGKTEV---SYALLRV --PSSPRHSSSPEDAYELIIPRRVFSYSLQQPHPPTPHLE NRVSY >gi|118397161|ref|XP_001030915.1|	  1148 residues, 50 /line  Sodium/hydrogen exchanger family protein [Tetrahymena thermophila SB210] -MKSTTYRLLLT---GIVALSI---FLQ TVLATLE---NGQQQNSNQTNSSESFQQKESSQDDMNSII -KKV KDSSIVKP-EEHIVKESRIIFFIFMSLT-I--

--GGLLKH V--NKRFPVAYTSMLFLIGYFGGLF-HDS--LGQLGESIKSASSINPVFTYKLQIQ SKFQSVLYSKQKHGILIIFLPVMIFQSAYNTDWHIFRRQFSQIFILAVPCVIVGSVLIMA FIKL---LYRGD--EYSLSSTFLLGSLLSWT--DTVAIGAILQE-IGA-PKRLNSL IKGESLMNDITCVALYKVVKEV--VR-ES-IT-GFWGSVQYFFV---VALGG ILFGILFGFVTSFWIKKIFNDEIHAVNIVLLSCYLLYFFGQNITIFGQSLNGIVPLVSFG LFMSASGKKRIASQAD-QAFRQFWNYISFCAETVIFILAGVIVSFTFYSEETS-G- --ITTPDYYKLFLIYIFTIISRLASISMFMHFLQRL--G-YGLTWHEVYVLAYGGL KGAIGVSIALIVSHDQHFNSEMRALI-LFEVAGNCLLTLLINGSTIKFLIQY LKITPTSQLKDKLFMDYLEKDFKEELEQQVKELKES---KYLK-NADWDNDVLVLS --GAKKQQEYMLQLDKK--IQE--KEQNQEDN-KKKEENELQVV LLKDEKKYQENDRVDEENKQEDKPRQERSNSNSSDSSDEDNENSIKQDDET-LIFIRN-I FLKRLKSAIWDLFEKNQCTGESYIRLCEAVDWDLDLET--S--- -LMNNW-TYLKRQFSEGYIHFYSTL--- -RNWT-IIGNW-

---AKKQ-LFQHISGIFDM- ---VHTYLEAHKIA---MTNL--- ---LSEA---QENEIYAKQYLDDFLDISFPDVSQQIRTKKVAFT ILE---YQKDIIKEKSAQGQLDEKE-FFSLKKKIDQNIIQINNL --TPS--- --WNELKF DDFIKSQP---LF--QLLSQHMKEKAKFSEII SQATEARFDPEQFVFKSEKK-ATHIFVIMRGGGTESYK--N-DLGKFS VKRGVGH--ILPIQQLLNSN-NKYQTEF --QADCMMI-TRQIEIKKIQDHIKCHHE--IEHHIYRESLPYLF-KIHYQQF-APL SVLDIE---KIEDI-INKTFVRRIKKDTI-FEMQSGGIL- --ARGEVQLVLNEI---GQSSLNVFEDDQNNVV-KKRE-- SSEVNIQEQDARLRPNF---QSEQDQMP EKV---ITAY-SIINP-NASYYTYKTTKKSIIFEFTNP-- ---EEIRLLTTALRR- ---QRATLITPNSALRNLLKK---

---YN >gi|118589284|ref|ZP_01546690.1|	  994 residues, 50 /line  putative Na+/H+ antiporter with cyclic nucleotide-binding domain [Stappia aggregata IAM 12614]

---M-ETPLITGAFALLLITISLL-Q--

--PLARRL G--LAPSVLLATVGTM-IGILATYL-RYTAETN--AFNAIADVFINPPLDSEM--- --ILYIFLPILLFQTALTLDVRRIIEDIAPILLMAVVAVLLHGFIGFA LYPL---ATLFS---LTDITLIAASARLHRRHHGPGRVVAIFRD-IGA-PARLGRI VEGESLLNDAAAIVIFVILLHM--LT-GHETM-TVGESAIAFSR---SFAGG IIVGALLGRIAVSLLPVMRDIPLAQVTLSLALPYGTYVLSDQFVDVSAVVAVVCAG TVFNLYGPARIQPASW-QFLHAVWEQISFWAASLIFLLSAILIPRFVEGF-- ---TPIDILLLFVVIVAALAARAVVIFGLLPVLSVFRMG-QAVNDRYKTVILWGGM RGAVTLTLALSVSEHAMLSDEVSVFV-TKLATGFVLFTLLVYGTSLKPLIRL LGLDKLNARDEALR---TQYLAL-ALSDVRQE---LETAA-RNYHI-APRV- --TDDVLKDYETR--AAA---AAAET-NKLE- -ELKDWDRVRIGLI-A LADREQQLVLEHFHDKTISGRSVSRFLAMTGRTGDLTRS-E--- -GRSGYNQAARQPLK--FGLGFRLA--- -QTLQ-RRLRI-

---ARPL-AIRLADRFEFL- ---LVYRILADELVDFNNRRI-RPLLGD-RVA DILQDTL---AIRQDETLAAIDA-LRLQYPDYADALEGQFLRKA GVRL--EETAYDEAKEQMLIGTELH-RELLRDAERTR-KACHTR --PKL--- --DLGLKT RELVSAHP---LF--ADLTRKQQK-AIR RMMRPQFATPGEKLIRKGDR-GDAAYFIASGAVEVRAP--S-HNIR-- LGRGDVFGEIALM-TG-GRRSADV --VALGYCQ-LLSLRAQDFKALLGENED--LRNH-- VA---MLT-K-RRQLMNMDDGEAELEDPVFP- --IFSEIRTSTRSE--EAPD--PEAGPSEQET NETEAEVFTFDETDA-QNDPSLTEKLNA ADTVTKTVEETPLPDNERDSDANE-SEGKAAAKEKSESNTGSADEKE-

EKGGAE---GAQPRMT TSAA---TSSPDEDKTEPAEEVRARSMPEK-TQEPNAKSHET-- A >gi|118791508|ref|XP_552951.2|	  1222 residues, 50 /line  ENSANGP00000028764 [Anopheles gambiae str. PEST] ---MAVMLKQEVNLSRRACR --PTTTNNDDCLQEQRTLLTTPTEGGSWHNDTCYGGGGANSRLVTVPAPAKELTDS SRSGGLPSSSSS---SSLSC-LLATIVMWCTGQVLLKLR- --QAGQGG-WREVQQPPRLSRLCIYVVF-CSALL-SHNAFVLARPNLSAPASGEKV PVGQ---LSPLDLAFDASSGSLTSASQLKRSAEAAAIIASTAPSADGGAGHEAEDTALGH GRVGEGEGGEHGGEHVVER---YPVSQVDFSRVETPFVIGVWILSASIAKIGFHMT P--KLSRIFPESCLLIVVGVIIGVLLRYATNLH--V--SPLTPNT--- --FFFYMLPPIILDAGYFMPNRMFFDNIGTILLMAVIGTIFNIATIGG SLWACGQTG--IFGVD---LPFLHIFLFSSLIAAV--DPVAVLAVFEE-IHV-NEVLYIV VFGESLLNDAVTVVMYHMFEVYNEIG-AS-EI-IAVDIVSGIASFFVVALGG TIIGVIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAE-IFHMSGILAITFCG ITMKNYVEQNVSHKSH-TTIKYALKMLSSSAETIIFMFLGVATVNNKHVW-- -NTW-FVLLTIIFCSVYRILGVLILSALANRF--RIHKLTKVDQFVMSYGGL RGAVAFALVLLVDVNH--IP-LQPMF-LTTTIAVVYFTVFLQGITIKPLVKI LNVKRSSKRKPTM-NERIHERFMDHMMAGIEDIVG- ---KTGNY NIRDKFK--RFDNRF-IRPLLI-K NLQG-PEPKILETYSKLTMR---DAMDYMRR-NP-- STIGQM-SGTESM-SALFRNYTSYFGGSPSFTNLENSTRNLDMQ ELDYNPSKKD-LTDAKIHHLLSEEL-KPYRR-

---HRRL-SYSR --HAVDDRDLSTQ-VNYKMQMNIR RMISEKKH--HKRSKRVKDGKQQ-NHVSFPEFVQNGSAKQFAND YINEVLHEDNEDEERQAAGPSEDWDGGGLTFTAKSSLDERGAA-KEDKRFSRESRFLES- --EQR--- --VATPTA IESVLPWK---RV--DE---SDDNGAIK QNEFPSWASNKEYLAYNSPS-ATFLGGLTQPKQAKSVIGLFR--

-RESSGSGGVV- --IGGVTDSE-- -TSTPVAATTPVGRM-AAVPKDKR--SA SIAGYITIDGGDTAGNPMLDPLGISRAG-PHATAFP-VTASHRRNNRRGSMLELSG EAIPEENYTKSLPERDKYGARRAPALIKASSTNTPKSAGRRSGG GGGPVNPQTTALLSASSTDSDEDDEEEGSGDR--HRADDA TRRLNGAGNNDDEDEDDDEDDDDEDEDCAD-- EQHPI >gi|32450774|gb|AAM63432.1|	  1179 residues, 50 /line  Na+/H+ exchanger [Aedes aegypti] --MVAHSLQQEVNLSRRACRIPKW---P LSGA-QQEEENDEEVLEEQ---LLNGANQSPASEVAAFRLGPVHSENSPGGIDEDPLSFR NRRMHDGRMGSV---VDFSCDLVARVFLLVKALVMGVLRFDLTSPKRA SSSSSNSS-SYGSQFSKNLVKWCTWAIV-LSVVLANHGGFVLARPKNGVVTADGVDAASV ASGQWELLTPQPVSSDGAGGGQISGS---LSSVKQQDDQSHGGEL--- --GDASHGEGHEVER---YPVAQVEFSRVETPFVIGVWILSASIAKIGFHMT P--KLSKIFPESCLLIVVGVIIGVLLRYTTNLH--V--SPLTPNT--- --FFFYMLPPIILDAGYFMPNRMFFDNIGTILLMAVIGTIFNIATIGV SLWACGLTG--IFGVD---LPFLHVFLFSSLISAV--DPVAVLAVFEE-IHV-NEVLYIV VFGESLLNDAVTVVMYHMFESYNEIG-AS-NI-QVVDIVSGVASFFVVALGG TIIGVIWGFLTGLVTRFTDHVRVIEPIFIFAMAYLAYLNAE-IFHMSGILAITFCG ITMKNYVEQNVSHKSH-TTIKYALKMLSSSAETIIFMFLGVATVNNRHIW-- -NTW-FVILTIVFCSVFRIIGVLILSAMANRF--RIHKLSKVDQFVMSYGGL RGAVAFALVLLVSTDH--IP-LQPMF-VTTTIAVIYFTVFLQGITIKPLVRV LNVKRANKRKPTM-NERIHERFMDHTMAGIEDIVG- ---KTGNY NIRDKFK--RFDNRF-IRPYLI-K NLQG-PEPKILETYSKLTMR---DAMDYMRR-NP-- STIGQM-SGTESM-SALFRNYTGVFGGSPSFSNLENSTRNLDMQ ELDYNPSKKD-LTDARIHHLLSVEL-KPYRR-

---TRRL-SYSR --HAVDDRDLSTQ-VNYKMQMNIR RMISEKK---HKRSKRGKDGKTQ-NHVSFPELPQNGSAKQFAND YINEVLHEDNEDEDKLPTAAGDDWDGGGLTFTAKSSLDEKSEQPKNDKRMSKDLRDLEAA --ENR--- --VTTPTA IEAVLPWK---RV--DE---DDENGAIK QNEFPSWASNKEYLAYNSPS-ATFLGGLTQPKQAKSVIGLFR--

-RESSGSGGIV- --IGGVTDSE-- -TSTPVTATTPIGRVKKDKR--SA SIAGYITFPGSSDAGD---DPLGVSRAVVSHANAFP-VTASHRRNNRRGSLLELSG EAIPEENYSKSLPDRDKHGPRRGPTLIKASGTPKPARNSK ---SNNPQTTALLSSSSTDSEEEEEE-- DEDCTD-- EQHPI >gi|66518336|ref|XP_391857.2|	  1107 residues, 50 /line  PREDICTED: similar to Nhe2 CG9256-PA, isoform A [Apis mellifera] ---MYLAGRLCVVFALYP-P ASSP-NDLQEDRRMKLWEQPCREPNALKGSSWLEVSSDGTEG--DSAPVDER ERAARSPRSAPQ---SPCHV--VMATRAVTSTMIAFVLILLV-- ---A-GWPTGGQTGLVKF--YESV-PDHLQPDRRIPINDYAMHGPIVDD--- HELPRDLREPYPGKSFGP-MGPIDGS--LPDDVSFRSLSS GQEKGANSIELLSSHAVEKVEKHKPEYKIMSVEFHRVETPFVIGIWIFFASIAKIGFHMT P--KLSKIFPESCLLIVVGVVVGVLLFQASSVH--V--SPLTPDT--- --FFLYMLPPIILDAGYFMPNRLFFDHLGTILLFAVVGTIFNTLSIGA SLWVLGKSG--LFGFE---TPLLQMFLFSALISAV--DPVAVLAVFEE-IHV-NEILYIV VFGESLLNDAVTVVLYHMFEAYNEIG-PT-EI-LYTDVLSGLASFFVVAIGG TIIGVIWGFGTGFVTRFTHQVRVIEPIFIFVMAYLAYLNAE-IFHMSSILAITFCG ITMKNYVEANISHKSH-TTVKYTMKMLSSSSETIIFMFLGVATVNNHHDW-- -NTW-FVVMTIVFCSIYRIVGVIFLTALANQF--RLHKLNKVEKFVMSYGGL RGAVAFALVLLIDPKH--VS-LQPMF-VTTTIAVIYFTVFIQGITIKPLVKI LNVKRAEKKKPTM-NERIHERIIDHVMAGIEDILG- ---KHGNY HVRDKFK--RFDNKF-IRPYLV-R NHYG-AEPKILETYSKLAMK---DALDYIRR-NA-- STIGNI-SGTESM-SAIFRNYSN--TGQFNGSPSCSQLE-AGWNIDLQ ELEYNPSKKD-LTDARIHHLLAEELCKPYKR-

---HRRL-SYSR --HAVNDRDLSTQ-VNYKMHMNIR RMMGEHKH-RHKRSKKLLKDGKQ-NHVSFPEFQQNGSTKLFTQD YINGVLYEL-ENGDTSKPSSKEDWD-SAITFTARTSAAGKDNSGVSCRSVSLNVKRDERE --SYR--- --VTTPTA TETMLPWK---RE--DD---YDSGHPIK QNEFPAWCSNKEYLAYSSPS-ATFLGGIEQPK-VQSVIGLFR--

-RESVCTPDGI- --DCQET- VDER--DE -YTLTGTEQTED---SPTKTFSEYEKDNKKGP-TRRVSMMELGS ---MEKSHSDKCTDDGSHSLPECWNAQRVRMTSFPYSA-- ---QVPSLSTALITSSSESSEEIDEEEE

---KA >gi|119924122|ref|XP_001255172.1|	  1267 residues, 50 /line  PREDICTED: similar to Solute carrier family 9, member 11 [Bos taurus] MNGRFEAVIDKTVQLQKLFIFHEKGRMTEAGAEGQENILLSA---CRVKNEWLETH LEAS-INELFEQKQQLEDIVTPI---FTKMATPPLAEGIAGFESLENL VWEQGCPDKLSRGCEGAEDVRLVCTSESVNSKSHPGSSTGTDKTMSKTNVSFWVQKEGNR PDLLCGRA-ADYTVGKGHFLILVWSTLV-L--

--GGLLRA F--LKNSEVIVLTILSLFGFLIGQL-AYN--FVEMHQVIYPLLRTSSFS--- --LYCYFSPLIIFMAALDVDFYILKNVFWQVFLTGLISFATTFIIIGY VVLK---FNKYS---WDLQSCLLFSMALGIT--DPIYSVNSLKT-VGI-SKMYTDI IRGESMIICGFTSIFFAIFKTG--IL-QMSNF-RELHVIMGLTL---DILGS IACGYWCARIIQFILTDLFSNTLTNIIFCISMVYMTFYIVE-FWGMSGTVALATVG LNLD---SLSFKPRIK-LIITKFLIMFSCIFQHLIYTFFGIVIGCGEVKY-- --FQFHTVVFMFILFVTVNFVRFVTVVLVSPILMHS--S-YEYNWRWGIVIAWSGI KGVFSLLFAPEVHNLAEQRVESPQLF-ILYIQVISLMTLGINSYVMTRLAKT LDLCVLSIPRQMA-MQNAIKHIQEMIQSRITLFKTE---KLLT-NVNWTL-VEE-- --KTKIEY--IIPTP--HVSSD--SKAKEEF- -PTDEVL-IEEARL-H VAIIQISSFEKQCNDGVLSVEAARTLIGATKSYCHIQGK-FMSIYDVSTYVRARS- --WLVKFKNMLTFLEYHKDKTPL-FLYGHNKFLIFIYHIVFSEEFENAEHIIGIMYIYPM IMHLWPTARK-LNVSGLIFVNYYFVFLYL-LESALKIIIL K-RKYFHQHWNTLEFFIVLIGIVDIFCIYFVR--LRPDNL ILIQFTVIIGYLRIIRFLPLLKIIIPLLINIVDVQ-IKKRLSLTYSI- ---TKGYVKSLEDT---KFLI-RQISSRKSID QKLYEIL---ETNKRDAVKELGL-IEHEGRDVVIALKTKQAIRN VIA---KALKSLTFLSSRGIIDKYE-SVEMNKVLLEKIKSLNNF --PMA--- --IPLPTP DKYLHNII---WL--EN-KDVLIE-FFK ERAKLAYFDYGDVICKEGEM-PQGIYLIISGMAILESSPPTFGIDRSL--RPD-RESTTR FTEYCTSGDIIGELSCL-LK-REIEYTA --ICETILQVCFISLEDLYEGFDFFWPS--LEYKIWLKLALSIAYQYFESSLVDED LKFQKC---VMLNH-AYVETLSSYNEMIIDNVNMKFVIL- --VYGSVIDTKTEV---PYFA-PCI--LPKTCEQVQ GT-SDLSKLLVIQAPAPDKN

--DGNAKVMGNTGLGMTKRNYQWKK--- ---KD >gi|73961353|ref|XP_537189.2|	  1128 residues, 50 /line  PREDICTED: similar to sperm-specific sodium proton exchanger [Canis familiaris]

MSNTNSSFWVHKEGHK PELLCGSS-ASYTVVNGHFIMLVCSTII-L--

--GGFLKT L--LKNSEVTVLMILSLLGFVIGQL-AHN--SIEVHKIVYPLLKTPSYS--- --LYCYFSPMIIFMAALDVDFCILKNVFWQVLLIGLVSLLMTFIILGY VVLK---FNKDL---WDLQSSILFSMIVGMT--DPVHSVNSLKT-IGI-SKTYTDI IRGESMIICGFTSICFGVFRSD--FL-HISMF-TEFRVILGLCL---DILGS IICGYSCSRIIQFILTDLFSNTLTSIILCISMVYMTFYIGE-SFGMSGMIALVTVG LNFD---SLSFKPRIE-VTITKFLIMFSSVYQQLIYTFFGIVIGCGETKY-- --LRFHTVVFMLILFATVNFVRLLTIVLVSPLLTHA--N-YEYNWRWGIVIAWSGI KGIFSLLLAPDIHNLADQKVESPQLF-ILYVQGISLMTMGINSYMMAHSART LGLCATSLPRQMA-IQNAIKHIQEIIQNTITLFKTE---KVLT-NVNWTL-VEE-- --KTKIEY--IIPSDAYNNVSH--DDIEEES- -LTEEVL-IEEARL-H VAIIQMSSFEKQCNDGILSVEAARILISATKSFCPIQGK-FMSIYDVSTYVRARS- --WLIKFKNMLTSLEYHKDKALF-ILYGDNKFLLFVCHVVFSEEFEYAGHIITVMYIYPM IMHLWPMARE-LNVSGLISVNNYFVFLYI-FQAAMKIISL K-RKYFHQYWNTLEFLIMLVGIIDIFCIYFVK--LRPDNF ALIQMTVILGYFRIIRFIPFIKLIIPLLINIVDVQ-IKKRLRLMYSI- ---TKGYVKSQEDT---KLLI-KQISSRESVY QKLYEIL---ETNKRDAVKELGL-IEHEGRDVVIALKTRQAIRR VIA---KALKNLTFLWSRGIIDKHE-GIEMNKVFLAKIKALNNF --PMA--- --IPPPTP DKYLHNIV---WL--EN-KDVLIE-FFK ERAKLAYFDYGDVICREGEM-PQGIYLIISGMAILHSSPPTFGIDSSL--RSE-RGSKSM FTEYCTSGDIIGELSCL-LK-RETEYTA --ICETILQACFISLEDLYEGFDVFWPS--LEYKIWLKFALSVAYQYFESSLIDED LEFQKC---VTFNL-AYVETLSSYNEMTIDNVTMKFVII- --VYGSVIDTKTEV---PYLA-PCI--LPKTCEQIQ GT-SDLSKLLVVQPSDPAKN

--TDDPKVMECAFSEDLWCPRVYGA--- ---TA >gi|125821741|ref|XP_001345326.1|	  960 residues, 50 /line  PREDICTED: hypothetical protein [Danio rerio] --MRGLSLLLFITLARDAVTDL-- --YVTGASLPPKL--- GVSAAPPATS-- -PVAARYI ---PREYGHPGIALARSA--EEPTTP-- STEDGESSHHHGGGFKIVQWEWSYVQTPYIIASWLLVASVAKILFHFS Q--RFTTAVPESCMLILLGLALGTVVLLASKKQPYQLDPGL--- --FFLFLLPTIVGDAGYFMPARLFFDNLGAILMYAVVGTLWNAFCTGF CLYGVKMAGVIDEKVD---AGLMEFLLFGALISAV--DPVAVLAVFEE-VHV-NETLFII VFGESLLNDAVTVVLYKVYISFVEVG-PG-NV-NTADYFKGIASFLIVSIGG TLVGLIFAVILAFFTRFTKKVRIIEPMFIFLLVYLAYLTAE-LFSLSAILSLTFCG IGCNKYVEANISQKSR-TTVKYTMKTLASIAETIIFIFLGISAVDKS- --KWAWDTGLVVSTLIFILVFRAMGVIGQTWFLNWF--RLVPLDKIDQVVMSYGGL RGAVAFALVVLLDKEH--VK-AKDYF-VATTIVVVFFTVMFQGLTIKPLVKW LKVPRSTNRKPTI-NEEIHERAFDHILAAVEDIAG- ---LNGYH HWRDKWE--QFDKNY-LSKLLL-R KSVYHKSELWEAYQKINIRDAISVIDQ-GG-- -NVLTSARVSLPSMASRTS--FPEVTNVTNYLRENGSGVCLDLQ VIDTVPGAKI-EEELETHHVLAGNLYKPRR--

---RYQS-HYSR --HFMTLGEKERQ-DREVFQRNMR NRLESFKSTRYKRHKKDRNAKEQ-DTSDKP---RRNVSWQDKDP LVAPLATEEDKHDPTEVDKDDDVGIIFVARRTPETPKE--

--RPKSAALDVCQSPIT-A- -PPSLTCGEKNLP-WK-SGMGSLP --P---CVSVEATKIIPVD- --L- --QQAWNQSISSLES-LASPP-APA--EPLHPRISALSR- --LGGPLRTPAKDKSAGVDAGLESTTSS PSSGQFKYPMGKEE---EEEGALSQQHR EMQPLMSSLRPPP--- PPPPLAAQSAGKRRNPCVYLRSL--VTVPPTG AEPHSR---KPTQ--- L >gi|126325719|ref|XP_001365700.1|	  1190 residues, 50 /line  PREDICTED: similar to sperm-specific sodium proton exchanger [Monodelphis domestica]

---MKDSHFPLPLILFFIGCSFEIL-SF-ASYQ--VKQYAEMLQ---WMDPVI--- --FINLFTPIIIFSVSFDIDFYMLQKLFWQIIFLTVPGFFLNYALVDW YLFS---VNKLL---LKGITRMLFAIIIVCT--DPMLTTTAIKN-LGL-SKGLTHL IKGECVFMAALAENTFKITLQI--AN-NH-HKEISTKLGIIILSDILI---KFVGS SLFGFVMYKAFQLWLRNIFSDDITEGMLSFSLIYISFYVAE-WSGMSGIITLTVLA LLLNS---TSFKPGAQ-LFLFKFWKSLKFFAYLMIFTLIGLMIPAHTYLY-- --LSFSDIYYAVHFYFTLIVIRILVFLIMSPILSRL--G-YGFTWRWAFTIVWSEM RGLLNINMALMFSYTD--NALGTEGEKSQI-LLHGVTICLITLMINSITLPRAVIQ LGLRDITLTQRKS-LYYTVQHFQGIIKASASALRFD---RDLA-NADWNL-VDK-- --KIMFTNPYKLKPEEER--QNLKCPDC---NK--EIRE- ASINTEI-MELARI-R LLSAQIASYERQYIHEILSQSAVKVLVGAAGSFGDKKGE-FMSFQTIRAYAEKKK- --FFNFVRKILLNWVYNTRKEKG--VPSKNPVLLFCHKIVFNDEFESSVYLIIILNMAPL LISWIPQLYV-IYEKEARTVNHMFLSFYI-IESILKLAAM R-KGYFQHNWNLFELLIIVLGIIEEILMVTDA--FKN-SI YVFQALIVLKISNLLRVFRILKLITPVLLQVIDRR-MTHQLSFRYAI- ---LKGYVQGEADI---ACLI-DKISSSKLVA EELRKRV---SMNAERAMKELGY-LEYDHPDIAITMKTKEEINS LLG---MASEILKNLKSKGIINKAE-VAEIHKIIMAKRKHVFDF --EPV--- --IKLPSL DEVLYHIS---WL--NK-SKFHIN-FIK KKVKILTFDCGNNIFEEGDS-PRGIFVIHSGMIKRHSSKPYLGLDQQLLETKE-KE-KTV YADYLLSGAIIGELNCL-TE-KPMTFTA --TCKTVVETYFINKRDIYDIFNNCCPS--IEYKMWLKLALAIGAKKVKEILAYED WTYNLQ---LQLCN-VYVRDVLLGYKVDIYDETVSYVIL- --VYGSVEDCQLQK---TYFA-PEL--IPKTCHQIK GT-ARITKILVIQTSIDLKK---CRSNTARYVPVCKHIRAGSKHEEVS PAFYQETNEDNAKEPFYALIMHVPQRRPSTNSTDDG-YENVVPKH---

--MTKQ---LADRCET EYAVVRVPSSPQPSYSFQDEEYELIMPITH-THYPSHLNWMN-S GNLNR >gi|145341792|ref|XP_001415987.1|	  1247 residues, 50 /line  CPA1 family transporter: sodium ion/proton [Ostreococcus lucimarinus CCE9901] --MTPR---VGRTLLSAAAS

--NATAVN-AAAHDDATAPLWFIFISLA-V--

--GSAART A--LHGTSVPYTVVLFIIGMVMAVV-YYYA--D--LGLLEASLSAWGGINPHV--- --LLACFLPALIFESSFSMEWHTLKKVLPKVLILAGPGVLMSMALTGC VLRVFPFD---FSWAFCMMVGSILAAT--DPVAVVAILKE-VGA-SKVLGHL IEGESLVNDGTAIVVFNVFLAI--AK-GE-HL-SFGDVMKDLIT---QPILS VITGVVVGELCLIWLRNSHKDHLVDITITLFAGYISFMLAEIVIKCSGVLAVVVLG WYLSAKGRTFFKGNIQ-HSMHHFWEVLTYAANTIVFILAGFLIVADILLGELDIK- --ASD--LGWGILLYLCLNIIRFVVTAMLFPWMNYYK-G-HVLSMRETFIAIWSGL RGAVGLALALVVLEDD--AHF-TKRERGLT-LVMVSAAVIGTLLINASSAAAMLRI VGLLTPGLSHDRT-LLAARKAIHERALAHYDEKLDQTGAQYLG-APDFTA-VKQ-- --LVPFLRTQTDETEIEF---KHE---IA--- -KMDAQL-MHEMRD-R FLAGLCKEVWSMLEDDLIDAKVAHGLLIACERATDKSKS-N--- -VLCTFDEFNRFM--- -KQSR-VKSAV-

---VKAFERRAWGMRIIKTLRYLRLVEEGWMG TRRQMQGLHALISAHRLT---SEQF-KSLLGKNEEEEQAKEEAQSEVAELAKSYTLTKAG VGENLANETSIKSHHVRDVLFES---DTEVVQAVEMLKE-MQHAHNAVARSLRSEALARE ILE---VTMEETKLLTHTGLLDESE-GSMLQAEHDLYLQRLIMH --PLP--- --PSRTSP GRILAAIP---LFDFTQRVGIKSREIRK-HFL REAEVVEFNVGDIIIDPNVKLNDGIMLVGNGVVLIESA--A-DATQQI TAGCK--SHPHAWALALYEAL-ANDANEEEPNRSGI RATAQTTMF-GFVLPRSLLDSLRGDLREAETLEFMWRVVLGLLA-ETVLRSELDSV LPDLPV---NKL-V-RAGKLVKISQGSKLEHDDRQVVIL- --LRGSLYNNTC---GNIPAP-CVV--TFKRTGMLSNAT---TSASSALESKLESRLSAL KF-GKNGLVRGSSQNLAAL-AAKMSVDESASESLPVE---PDRDGYCTFESVNDLLIYVI PTDKLLQSPTSG---K-SRTSL--RAQKKREFLRGLS--N KVSRQ--RSIFIGPDNRLNAQKSTMPRRSID- ---SDRRSIEFDIESGVANATSRSPNRRLSLQLPRQPTVAEDADNPIGEDPRTQLT SNSMISLGTDDDNAQDTHRS-DDLVP-LRSRSRVWDDSPIPAPRVLPSRDYEDPST QHTIS >gi|145506977|ref|XP_001439449.1|	  1025 residues, 50 /line  hypothetical protein [Paramecium tetraurelia] --MYIYKA---GIVLLML---GVGQC--

-EDQPISA-SSDISGTALSVFFIFFFLG-I--

--GSFMKE I--NKKLKIPFSPMLFVLGLFFGFY-WDS--LGIIGQSCKKISEIEPIG--- --VLLIFLPTLIYESGYNFDWHLFKRLFAQTAILAFPCVIILSTLLQL SVKV---LLNYGDDYFTWESAFMFGAMLSCT--DTVAVLALLKE-SGA-QKRFQSL IEGESLLNDGACVMLFQISYGI--VR-GR-SA-SAFDVGSLFFT---LCVGG TLIGLIFGMACVYWIKKIANDEILVLNITIVSAFLVYFISENVDF-GVHISGVLGLVSLS LFMAAFGRSRISHEAD-HALREFWEYVVFASEVIIFILGGIIAGIRVFKDESEI-- ---TQLDFYKMIALWWCLMGCRFISIALFYPWLKNL--G-YGLSWSQILVLTYGGL RGSIGIAFALIVAKDESLPTKWRDII-LFHMSGIAVCTLVVNGTTLSLLIKL LGLSTQSDIREKI-YSNFLTKLNEEIDNECKKNNEL---KYLK-EADVEY-VKTLSG--F KVYQSDCNQIIDKLAKHEKAQKEIQM--KNIHQPLM---EE--EEEE- -ELDQNL-LTEIRR-I FLMALKGIYMEQFESNQCSPDTIILLTESANLDLDN-DK-E--- -HMNSW-EFLQSQFSERYINLLFYM--- -KDKF-LIGIL-

---ARNH-LFSYIYTIYDA- ---VSAYIEAITIL---KEEA-SHYHFSQNLL LEILNEV---EDNKKSAISYLEGYLEVSFPEISRELHTKKAAFE ILE---FEKSVLKNNLQSGQLNDKE-FLRMKRNIDKKVKNLNDL --NPP--- --WQMPSL IDILTQHE---LF--KSLTQPNIL-KLL EGSREDSFGRDQLIFKEGDR-ASEICIITRGAGNEFSD--R-SKI--- -RERR--ALN--EATPIYMLVAPS-IRYQTSL --VADCVIN-ATFIKIQTLQMIMKQIPE--FEEAIWRNSIPLLC-RVYSDQLKPLC NLKINQ---IVEIV-SKSVFQKIKKNQLIR--FEQGGIL- --LKGTLCEGKE SI-QEASSEDEDALKNSGE- ---DQDSTQKDALCLIGPTSSPLR ARTGIIVLLFKQY--- ---QMLEQYNQLNQNINEGAKSSNR--- --RSSKSDLQKRSLTVVH-- - >gi|145520052|ref|XP_001445887.1|	  1036 residues, 50 /line  hypothetical protein [Paramecium tetraurelia]

--MSEHLDVAQIAIVIFFIFVALT-I--

--GGLVSE I--TKKIMIPYPAAVFLVGILIGSQ-FNNIHNHLLHRTVQAAFNIDANS--- --NMTLFLPALVFSSAFNADIYIMKQQIMQIFVLSIPSLLISASLICL GLKL---LLEYDDEYYSWGFAFVFGVVVTCT--DTLQVVKLLNN-AEA-PKRFISL VQGESLVNNCASMVLMLIAVNC--AR-GD-C-DLLTVELSYGLS---LLLGG AFVGIMFGLFTVWWIRRINHNSILTINLTIVSAYVTYFVAESVDL-GFRKNGLIAVITLG LFMSAFSKIRIRTEVE-HPLQIFWQYTQFANETIIFIITGVTCGYKIFDQQSP--- -YIRKQDYINTILLYFYILLSKFISVLLLLPTINLY--G-QQVKMSEAILFSYSGT RGAVQLMLALLVVKEPSFSDQWSDIF-LFHTTFIVILTMLINGSTIPLYVKF SGLCATAQYRAKV-RLNFLQEMKEQIEFKLNQMKED---YKQK-TIDWNK-VEYFSG--L AETNTQIQQKDDKLSKKQL---DEENKHKKEKESSIIGRF-QKLLKSKGLQD DFNDDDIDADD-IIETRD-R FLMALKQTYWDLYSQNQCGGKAYNLLIESVRWDLDTVEGRMCSWDFIYSVFYSPIYM---

-RFLYSLNKF--

-PIIRGF-SGDLLFDWVAIGYEV- ---ISTYVRAHEEM---ENMI-EEFPINVTLKKK-- --LSKES---KENRTNAENFIEGYFYVSFPEIIKLIQTKKSAQG CLA---SQGKYLLRKYELGELDFQQ-YQKLKLQLNNFVCNVEDI --RPI--- --WPQISI HTKLKVLP---LF--SEFNDDLLK-QLA LQSKELLFDKDECIYREGDL-ARYFYIITRGRVNETSS--A--YINYS ISKDIGQ---FLSCHHI--VL-ES-TLYISQV --VAASLVE-VIQIEIELMVSLYKQSLY--MQDYVWRDSIFSLSRFYPKELQ IFSLVDREIIENIL-TFVVFKKYQAYTSVS--FQ-AGILLQGRLTEQKQEKRIRL--EED QFEMNCNDGLQ-GPLLFPFLNQ-TYTY-QTETACSFF--LFDET KKE-EIMKLIQ-TERSQER- RRTRLQTDLRVSVSGVNRQSFGFSYLL- --R-

-PSKVNL---DV NESKH >gi|146165774|ref|XP_001015733.2|	  998 residues, 50 /line  Sodium/hydrogen exchanger family protein [Tetrahymena thermophila SB210] ---MSLEGQI-- IASG-GH- -EEA AGGHHGGGDCMTDHEQPYLILFVIMGLA-L--

--GGLLRQ L--NRKTGLPYTPMLIVVGIIVGCY-RGS--FGLIGSSAELMSHINPHM--- --ILFIFIPVLIFESGFNCDWYVFKRALVNILILAGPGVLVGAFMLGF CLKS---ILGYD-EDLTWNGAFTMGAILCAT--DPVAVVALLKE-LGA-SVRFNTL IEGESLLNDGTAMVFFLVFFGM--EK-GE-E-STPVSVTLNFLR---LAGGG PALGFICGMVGSFWLRRIIRDDVLTSTVTFITCYFCFYFAEFT---FLGVSGILSIVVLG LFMSAHGRTKIYPESE-HSVHTVWSFVQYSCETIIFLLTGVIVGKEMVSQ-- STIEFMDWVKLPIFWVLMMIARALMVFMFLPCLKYF--G-YGINKAEMWVLIWGGL RGALGLTLALIVAVDTDLQDEVKFPLGRRLRQLT-IFYMSGVATMTLLVNGTTCGY LQMIEVPQIRARV-VKNSKRNLSNACDDKLKELKMN---TFLN-LADWEK-VVEISG--C SEIKNELVS--GAEGQASGRRSTY-SSF --DEQEI-CSETRF-R LLRTLKTYVWEGYEQGQMGPEAAQLLNECINVSLDNTNLPLVVWNNIYSNFTDFATI---

-RLMFRLKNW--

-ILIGTM-AKNYITHHMAFVYEV- ---TTAFITSAEEA---EHLL-HNYPLGQQFINK-- --IVNEL---KNQVNDAYKYI-SELQNKFPEIIKAIHTKRAASA LLE---TQKKFLNEYKNNGYIDDGD-YNDIRKKVDMRCLELENM --TFN--- --WQEVSELQSF NTFVLRFP---IF--SSLLPEEIR-QLE KCHKSFNFYAGNEIYHEGQK-FDYLYVITQGTVTDALS--ASDKSQYT MIKGMGA---FLSFANC-VNE-NN-SRSVSTA --VAETDCT-LYGIPFATIKGIMSQNKI--FEKKVYLYSMIYFIRIFPEKAG PLRGMEENHLNEYI-VKSEFLALNARQSCN--FEFGGYLLVGQIENTDSGQD-NI--IDE FSY---IPPS-SKSY-ITSKNSYIL--KFTEV LE--

--RKQSIMDAHFEEQGVK-- --KFNQNLVSSSNQY---VA DESQL >gi|146180705|ref|XP_001021323.2|	  1114 residues, 50 /line  Sodium/hydrogen exchanger family protein [Tetrahymena thermophila SB210] -MNNSTDT---SAATYQP-- -NY- -FST MAAQAID--DSKISTESLVVFFLFGGLM-I--

--AGFVRE I--NKKTSIPYTPMLFVIGIFLGKF-SES--MGILGITISKISLINPHG--- --ILIIFLPVLIFESGFNSDWHTFKKQSGQIFLLAFPCVLFSAIFLLI SIKV---ILRYDDSYYTWSGAFMFGSILSCT--DTVAVLALLKE-VGA-PKKFNSL IEGESLLNDGTCMVLFQISSEF--AKKV--DQN-TQNQQYFDLFEVIKLLLS---LTVGG TLLGIVFGMIAQFWMRRIHNDPILTVNITFIVCYLTYYVAENVDI-GIKVSGIMALVSLG IYLSIFGKTKISSEEK-RTVYIFWKYVTYAGESIIFILAGVLVGVKVLTSNGDYDTMSGS DNVSSSIQTSDYFKLFGLYVCMILSRFGSIACFMSWLRKW--G-YGLTWKEVYVLAYGGL RGAIGNFISISFAMIVANDDSYSQKLRDII-LFDMAGNAILTLIINGTTTGPLIKS LGLCVTSTVRERV-FLNILQDLKEDTEKKINYLKSN---NYLK-MVNWDS-VKEYVG--L ADLEQRITRLESDLT---KREE--IEEYTRNI --R-NKN-VIDAKIDE LKNSNEFQEQQSFDSDSTNHNLDENMIVELNWDLDTEQERMNSWEFLSNYFYNPIYI---

-KVLFQLKGW--

-PIVGSY-AGNLLFNHISNIYDV- ---IAAYIEAHEQA---EQLCIDQFPFIPQVLEI-- --IIRES---QDNRMSGEEYIKNDLNVSFPEITKQIQTKKATYS LLE---CQKKIIKKGILLGKIDEKE-RDILMQQIDDRVVALDNI --KPS--- --WKAPPI KNFLENVP---FF--KLIHKDLLP-YII KESVEMIFEKDMYIIKEGEK-AKYFFVITRGSATETTS--Q-SFCTYQ EQKEVGS---LISPHHL--IV-PS-LRYLTSC --MANAVVY-VLAFPLSSIQKVIKVNLE--IKEYVWMQSLRALSQLFYNELK PLGSLDRNSFIKLQ-PKLKFAKYNKGKTIQ--CESGGILLKGQVSRKDLTDV-MM--TQS KVNNDEVKKSD-LIDGR-IYKAFCVLMPGQ-AFSV-FTEKKCTFL--HFAED CE--EIRFMIS-HMDYNVG-INQQTPH- TLNI-FSPVAVSGSHNKRNSFQAPHLS- --RFAGRHTFNNLEVVVQGSENKI ---NSGQQIELQKMKSKSYLNDQQIK-- --SVKSDDEESDD--- -NKEK >gi|148539552|ref|NP_001091927.1|	  1325 residues, 50 /line  sperm-specific sodium proton exchanger [Strongylocentrotus purpuratus] -MKKRVVKLREL---VPAV---AALAVAVLIQSATGSSGG SGHTPTTQATHADDHDLTTHNGT- -EEH DDGHDDGH-DDLHAHAPKVIVFISGSCL-F--

--GAISRS L--FKKLPIPYTVVLLILGAILGVV-ASN--VPLVEEHTRDVAHMDPHV--- --LLQIFLPVLIFESAFAMDVHTFMRSFSQVCILALFGLVVASVLTAV LAMN---LFNYN---WNFSEAMMFGAIMSAT--DPVAVVALLKD-LGA-SKQLGTI IEGESLLNDGCAIVIFNVFMKM--VF-FP-QLT---STVGQNVLYFLQ---VAVAG PLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEVSGVLAVVVLG LIVNA-EKTSISPEVE-VFLHRFWEMLAYLANTLIFMMVGVVVTQKAL VAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRI--G-YGLTWRNAVIMTWGGL RGAVGLALALVVENLA-GNDVIGSKF-LFHTAGIVVLTLVINATTIQTLLRI LGMSDISIPKRLA-MAGAVRRIHEGQNRTLNMLKSD---RFLA-DADWDI-ATAACE--I SDPYSALSDD---EN---APADELTLGERKSVCPGC-KAMVPNEPSPR --EFADM-MEEARL-R MLKAEKISYWKQFEHGMLAREALRLLVQHAEVAADEKDQ-FILVDDLKKSWQIKG- --IYPWLKRKLEDLISEKKIAAI-PMPKYKLG-KLMYKICHHMAFEVTINIAIVLNIVPI IMEFVVQDKMASVSTMAAPGSTVSSEPSSLQKIEDALRISNYVFFVIYAI-EAIVKILGL G-RHYIVSHWNKFDAFILVVALVDIIIAET-LLKGS--ITI-NL SSIKVVKLFRLLRGLRMLRLTKALIPKLILV-VNGKINNQLSLGYDV- ---GKGYIIGEEEV---GKI-IDRMVDNKKILRE-- --LKHIS---ETGRLQVVKEL-GLLQREHPGIAVSVKTRQAIRT ILN---HSRETIHELQGAGLLDEME-AHKLELTVEIKMKRLMNA --PSS--- --IPPPPP ENLLKNVS---WL--AG-DMKLID-FIK ARASLLHFDYGEVIVREGDE-SDGLFLIVSGLVKLYGK--S-AFLDHD NPPVT-AGSEENEVFED--YLTVGNVIGEMGVL-TK-KPRNATV --TCETTVQ-VYFITAEDMNIAIDTF-TLYPS--LEYRLWRVVAIRIATPLIMEQM AFQGWTQEK--VKLHLERGYLVDLAES--HFQ FNIDATLEDVI-LINGT-AYN--AHTREEI-RSPC-LISRTVHKLTFQYTAT EE-PRLFVVRNAEYNGPIL-DGRLDVD-SKRSLIS- ITEI-SSNMCLKHAAELRQKNSKVMLS- --RKSSGAAAKEEEDCIPNTSDVEQAAGVSPSVPTKT--- ---TPKPKSFLPSLGLSMSKERVNGEAVEESPVK-- --TKQGEETPETEEG---AA PRVNV >gi|71412494|ref|XP_808429.1|	  1208 residues, 50 /line  Na/H antiporter-like protein [Trypanosoma cruzi strain CL Brener] MDEP A---

--KGNDAA-EELETL-SQNVLFLMMLIFCG--

--GTFFMT --NMSKIPLPYTVVLFLYGIFVGFF-AHW--I--TPDVATSLGNIPPEL--- --LFYIFLPVLIFEGSYAMNVHALRRVFPQVLILASVGVVVNTCLLAL PVAC---FFP-E---WSWYSALLLGSLLSAT--DPVAVVSLLKG-LGV-DSRITAM VDGEAIMNDGTAIIAFKLLLPA--AR-VG-CLK---DSTWNIILKGVQ---LAALP IIVGPVFGFIQSYWLRHA-TGGIVKTCITVSVTYVCYYVAGNIIGTSGVLTLFFSG TFLSFYCPSLFPGREG-NLVYNIWEFLVHLGNTMLFSLVGLILVADVV PTLNILDLIIIICMYVAVIMARFLMLEILLPILNLF--P-YRMSQREVTLLAHAGL RGGVAVTLALAVLQTGI---EAGVNI-LKVTCGVVLLSLFINATTAEKVVTF LGHKRKQEHRMIQ-MEYAMDHLEVVRQKALQKNKNN---VSYR-SANWAA-AEAYVKEHL LNPYKGMSYLR---ED --E-DTVVNR-L LMKAFKASLWRQRDENLISETVVLTISRAVARAIDS-GE-LIEVRHLHRRKPSPHVEMTE ELEARLIEENLKP-LWVTVSE---IFLG-KGYLEWAHVRVQ--- ---QNAFMTL-LSFARCLDE VNPIKYQY

-AKNELHGRRIEAWM---TSQREEVRRVI-RLLYETYPAATMCIATSRAVLR AVN---ELRKGVEELHHYHGFGAKP-TAALEEMVQHMYEHIPRS WEPPRLDNELVIAALAATPLGRGLDPEEINTLSAMGSTKNLYEGEEIKLEDKLFHVIVFG SLKPKLNRWTASSEGEYGFGCVIGLERFVVPPQLRDNQMNRWVVTSTECQVLCIAYRYIE PFLWEKSFASVRAFWRAVAVETLLPTLEHMITLPVNL--TQ-SSRDHF-TSI MMSGNPLIGPKECNAMDWSL-QFQLCFYIRG--S--D-TTGLFC NGHTAPCYVSAFFARRLKWEDPQVVLYAVPVNVSDSGYVPWSQSA-NK-SPRGSFM --PQRSSAA-EA-DLSSAMMLDYIHHEP SSTYAEAAD--IFSSILRGIIPGE-NQ--PRS FKIDPPVADVG-SFDGVDACI--LQNPENF-VTNVPYLNQLFLRYATV LEGLCIAALRYVRVPTDPL-NAKHAQY-ISEQALE- FLMVFFNELTILSAALRRLSRRDTTTS- --SFAHGVKRQEKEEQLQDDELEDIRMIGKVIMWHRVAEMHGA-FQLRT--- ---MVLQMKSLANRRFRYLSESLRALAEEQPSLK-- -GADSVEELQR---IL LDLNP >gi|91086579|ref|XP_973405.1|	  1115 residues, 50 /line  PREDICTED: similar to sperm-specific sodium proton exchanger [Tribolium castaneum] ---MFRKL---SIIIFLL---YLAQILAEDTP K---

-KRPPPDFSVKYIFIFGCLLL---

--VTKTRH FIINKGIPVPYAAVCMTCGVLWGVG-TWY--SPWMEDVSLVWPTIINEF--- --D-VIFLPAMVFSTAICMDIHTFLYSFPQIFVISFPVALLASAMFGI LMRL---VIDRK---WTVVDSLYFGALTQAI--YPTEMLRLLKE-SGHRTKCVAIL LEGETLLSVSIAVAFTQMLGLH--IG-GW-IV-HWYQWLMGLVR---TVVVA LPLGYLFGVFGTFLMKLSYTDTSGLLIVTISMCYMSYYIVQ-WISSAGLPACTICG IFMG-RARATLSKERE-ESIINFWKMVIIMMCGILFVVAGVIAPITLR INVQMKEYVLVLVTYLMANVTRFLSFFLFSPILSRT--G-YGMSFQNMLICVWGGL KNPLILNLAVDLTMKVYGENSHRRQILYLHVVGLYMLMLFINATFIPVLLRS LGLMELSLSRRIN-MNNCLKFINEARTRTMAILKMD---RFLS-DANWPL-VTKCTT--M EHPYRKKASTEAEQE---EQEDEYLLAYKFTFCPDC-QKEVPNEPTPK --EMKDM-MKEAKL-R ILKLKKTAYSRQYENGMISRHAIRTMHQTVEIAMDSQEA-VIELDGLYKLF- --LRNHLQK-FLRNKSDTV-KPPRLEWR-LWCYRIVTHVAFTIFMNLVVLFQMVFI LYYFAVRVEKDDV--- --MHGFRTYFRSCCNVLEFIILLGVFMIIVFHATLNLTGAHMCYYVDLAL-- CFLLILRSLKLLRLVNYLAFCQRLPVALSKY-LDAKVDKHRALAFEL- ---GKCYITGEEEI---LEN-LHQIVDNDKIRES-IRERI ENDRLAITKRLGLAQKESIRERI---ENDRLAITKRL-GLAQKESPWVTTTVKTRLAMRT VLN---GMKDDIYELKLSGWVDDLE-YDKLLKSLSKRYKYV---

-DSVKLIPPPTS KAVFKEIP---YM--AE-EPELIE-FLY TNVSTKKFDPGEVVIKEGEN-LEGIYILISGMLMASYT--P-HPLILD NLKEKGAIPVVDHICSLTYDEPMSE--YIVPGNSIGELSTL-TG-RGYDGKI --LSETHSQ-VYVLYKPFIKKAMEMDDDPVNG--FECRIWKYISFRRALTVMMNVP SFRSVTQQN--LKYTLERSFLPNL-SN--YKV FVVNEMMEDII-LIEGL-VVD--FNTRDVY-AAPC-YIPR

- >gi|91086619|ref|XP_974158.1|	  1271 residues, 50 /line  PREDICTED: similar to sperm-specific sodium proton exchanger [Tribolium castaneum] MPKI---NLLLILALCESCNAFLNRTVGSDNP R---

-AIY-PSIPAEH--NVFYFFVIVML---

--ATIIRI VLIRYDIPTPYGAFMIMVGVIWGII-CNH--NLFVLLASDAM-NTNPVD--- --LVCVYLPALVFSTSFSLDVPIFLKTIPQLLVIGIFVTFLTGTLFGV LMRL---VIEPS---WSIKVGLTFGIFIVPI--NPASIVYLLKQQTT-ATRHISAL LEGEAIFNMLLAEMTHDLIINF--AK-GF-VV-HWYQFVMVLIR---FILFG IAFGYFVGLLGRYMMRTLYRYPLTIFMISFGFPFFTFFLSDIYISGCGSISVMILG TMMA-MERSVLAKETN-QFLTDMWETIGYSLDAVMCVTITLLATVEVA TIVTTSAYIRIIVTYLTYYSIRFICFLLFAPIISRL--G-YGMDLKCMIVCVWSGL KSPFSLALSLIFVEDAI-SAEKMKRI-FFQCVGIYFLSVLINGTFTRKILEF LGLREISMARKIN-MTNCMKHIFTKRNKTVAILKMD---RFLA-DVNWPV-VLEATD--M KHPYRMGMEDTEE---DNFFLLGYRFTVCPDC-KSEIPKEPTTR --ELKDM-AKEAKM-R VLKSKKMCYARQYENGMMTKEGIKILSQAVELAMDTEAA-VIQLEGLEKRFKEEN- -CIYRCIRKKVKH-LNRSQADSI-RPPRKYFR-RLCYRICINNTFEHFMLVIITIHCVFI TVSTIYHPPIDHL-DTIDKKLDVAISVLDLIFSIIYIV-EVILKIMAF SWIHFWEHGVKTYFKSVWRNIDFLVVVTCILQGYYDLKCFYAQIPESKY--G VFYRVLTCLRLLRVVRLFTVLKIFYPKFVTY-LDRSVDSQLAFTYEL- ---GKSYAIGETEI---LDM-LPYMIDNTAIREE-- --IKQKI---ERDKVIITKLL-GMVQKEKPWIAITVKTKQAIRT ILN---SMKEAANQLRTAGWVDDYE-QEKLFQVMGELWSKV---

-NSIKSVQPSAP KVIFKEVA---WM--AG-DQAVID-FLF ENVTVKKFEPGDVVFEEGTV-ADGIYIVVTGLFMIIYK--P-ESNVLT SLHEYGQLPIADYLSATQYEERVVD--YIVSGNCIGELSTL-TG-RAYNCTV --SADAHCQ-VYVLSKGVIKRAMELNPDPVIG--LECRLWKEVSIRMAVPLLMSVP AYQGFSQDQ--IKYALERAFVPNL-SN--YKI FAVTDMIEDII-LIEGC-AAD--FNTRESF-VAPC-CIPRTVQKLILPKSSL INIPVLLETKLLIIPEKDV-DEYDVMI-LAEDMCE- LVDTGASMKCLQHATQE--- -KTRKKKVKMMAARKKGTAVSKTLSKLQP--- ---DSND--SVGMLFFKRTDSETNSINMEEEEEN-- -KRNAEQTKQS---KT N---P >gi|145517548|ref|XP_001444657.1|	  986 residues, 50 /line  hypothetical protein [Paramecium tetraurelia] --MAEHE---SEFEGHEEELE---

--AP KDSLWR--DEHEMEKSANIVYFLTLGIV-S--

--GLILRE I--NKKTKLPYSPMILSLGILLGLL-QKS--LGYVGESASILSKMHPHL--- --IVFVFVPVLLFESAFNCDWYTFKYQMVNILLLAGPGCGWGAILLGA IFKL---VLQYDDNDMTWYQAFTLGSVLSAT--DPVAVVALLKE-LGA-SLAFNHL IEGEALLNDGVAMVFFIFFNKF--SKAASGKGE-A-VTASQVVLNFVR---NSLVG PALGLILGILAALWTKRILGDDIEVTWLTFVFTYLTFYWAEFC---FFKTSGLLAVVGLG LFWSAFGKTRIRSSVE-HSVHTVWGFVQYSCDTLIFLLVGIIVGTQVIEET- -FIHKSDYIRMIVFYFFMILARFIMILTFWPFLRCF--G-YPISKSEFIVLVYGGL RGALGLTLSLMVGCDEELPARFRHLS-VFYGAGMAAITNLINGTTCKALVQY LEMIENPVVKKKV-YKKYLEELIVNSQDKMRELESD---QFYS-MADWNQ-IEKLET--E IKYMLGSNKVQTS---SSNLYEG- -LTDQEI-FGEVRY-R IYRILKGLYYDKFEYGLCEEDTVRLLVESSDIGLDHTKAILNIWDQLYKNF- -LN--FSSV--- -NFFFKVKEM--

-PLIGPFARDY-MIKHLGFVYDV- ---TTTFLSCASEA---FHLT-GTFPMSKDAI RVVMEEL---NKEIEKAEGYLG-ILNDTFPEIVRAIQTKRASHS ILT---HQRHYLDDTQQNGLVDEKE-YQLLKKEINTRLVDLENH --QFD--- --MVLPSF HVLAMEFP---IF--SGLVSTDLD-NII KSAYEKKFGPDEIIYEQGMT-CQNIYIVSKGNVVDEFA--G-GTIRKG LGTLITYTNLIGDGTCMSTA --KTTADSL-LYSLNLKILKDLMSKNPD--FEFKIYINSLEYLRKMFENQAG PLANVEIKRLLDFLRTKSKLKKFTTNQKCD--FIFGGYLFRGELKDINNQV--YSQ YTY---IPPQ-DTEC-LVTKDCQCL--TFEDS VD--

SFNNQMLKQLDLDPHKDQQIQERYSQ-IKRTSMMEKSKL- N >gi|145543418|ref|XP_001457395.1|	  994 residues, 50 /line  hypothetical protein [Paramecium tetraurelia] ---MGQE---GEAITSTEGT

--QI QDSLYR--DEEKMEESANVAYLLTLGIL-L--

--GLALRE F--NKKTKFPYSPMVLACGLLIGLL-QST--LGYLGESASILSHMHPHL--- --IVYIFIPVLLFESAFNCDWYVFKYQMVNILLLAGPG---GAILLGI VFKV---FLFYSNEDMNWYQAFTLGSVLSAT--DPVAVVALLKE-LGA-SAAFNHL IEGEALLNDGVAMVFFIFFNKL--SKAAAGIGG-G-VTFGGVLLNFVR---NSIVG PVLGVVVGFFGALWARRIVGDDVEVGWLTFIFTYLTFYWAEFC---FFKTSGLLAVVSLG LFWSAFGKTKIRSESE-HAVHTVWSFVQYFCDTTVFLLVGMIVGTEVIEER- -YIYTSDYFRMIVFYFFMIICRYLMVISFWPLLKKY--G-YPMSQPELIVFVYGGL RGALGLTLSLMVGCDEDLPPRFRHLA-VFFTAGMAALTNLVNGTTCKALVNY LNMIENPVIKKKV-YKRYLTDMIVDQEDTIKELEGD---DHFA-MADWNQ-VKSLVG--S QQFLQEVVQLENE---IKQ---IQGGNLSRVSYEG- -MTDTDT-FGEVRY-R VLRILKGLYYSKFEHGQCDEDSVRLLVESSDVALDHTGSILNIWEQLFQSF- -TS--FSSI--- -KYFFRAKEW--

-TFLGGYAQQY-ITKHLGFVYDV- ---TTTFISCANEV---LTLQ-EHMPMNKSAV RLIMEEI---KTEINKAELYLA-TLNDTFPEVIRAIQTKRASHT VLM---HQRHHLEENQKNGLVDDKE-FNQLKSNIDARLVQLENH --VFD--- --WQIPTF HSFAMEFP---VF--AGVPKEELD-TII KSTYEKRYQSDEIIYEKGMT-CQNIYIIQKGNVIDEVG--S-HQLKKG LGSLLSYANLIGDGKCMTTA --KAASETV-LHSLNLNVLKSLMQKSEA--FEQKIYVNSIEYLIKLYESQAG PLGQMEQKRLGTFLRQKAQFRKFDVHSNVE--FMFGGYIIKGEIQSCIQDENEGVERYND YCY---VPPR-ENDF-NVTKALICL--VFDDA ID--

MIKQDRLEQFNLENH-EEIIDQRFSR-IDVQQQYQQQE-- L >gi|145546003|ref|XP_001458685.1|	  994 residues, 50 /line  hypothetical protein [Paramecium tetraurelia] MEA---EDTHSEGENV

--MH QDSLFR--DEEKMEESANVAYLLTLGIL-L--

--GLALRE V--NKKTKFPYSPMVLSCGLLIGLL-QSS--LGYLGESASILSHMHPHL--- --IVYVFIPVLLFESAFNCDWYVFKYQMVNILLLAGPGVGWGAILLGI VFKL---FLFYSDEDMNWYQAFTLGSVLSAT--DPVAVVALLKE-LGA-SAAFNHL IEGEALLNDGVAMVFFIFFNKL--SKAAAGIGG-G-VTFGGVILNFCR---NSIVG PVLGVVVGFFGALWARRIVGDDVEVGWLTFVFTYLTFYWAEFC---FFKTSGLLAVVSLG LFWSAFGKTRIRSESE-HAVHTVWSFVQYACDTTVFLLVGMIVGTEVIEER- -YIYTSDYFRMIVFYFFMIICRYLMVISFWPLLKKY--G-YPMSQPELIVFVYGGL RGALGLTLSLMVGCDPDLPPRFRHLS-VFFTAGMAALTNLVNGTTCKALVNY LNMIENPVIKKKV-YKRYLTDMIVNQEDTIKELEGD---EHYA-MADWNQ-VKALVG--S QEYLQEVVQLENE---IKQ---IQGGNISRISFEG- -LTDSET-FGEVRY-R VLRILKGLYYSKFEHGQCDEDSVRLLVESSDVALDHTGSILNIWEQLFQSF- -TS--FSSI--- -KYFFKAKEW--

-TFLGGYAQQY-ITKHLGFVYDV- ---TTTFISCASEV---ITLQ-QHMPMNKGAV KLIMDEL---RNDITKAEIYLG-SLNDTFPEVIRAIQTKRASHT VLM---HQRHHLEENQKNGLVDDKE-FNSLKANIDARLVELENH --SFD--- --WQIPTF HAFAMEFP---IF--TGVPKEELD-TIV KSTYEKRYQQDEIVYEKGMT-CQNIYIVQKGTVDDEVG--T-HILKKG LGSLLSYANLIGDGKCMTTA --RAASETV-LHSLNLNVLKSLMSKSEV--FEQKIYINSIEYLIKLFESQAG PLAQMEAKRLGQFLRQKTQFKKFDVHSNVE--FMFGGYIIKGEIQSCISDDGEGIERYRD YCY---VPPR-ESDF-TVNKPLICL--VFDDA ID--

IIKQDRLEQFNLENH-EEIVEERFSR-IEVQHQQQE F >gi|145543420|ref|XP_001457396.1|	  997 residues, 50 /line  hypothetical protein [Paramecium tetraurelia] MSS---DDLGGQDENYES--

--IQ RDSLWR--DEHQMEESAQLIHFLVLGLI-C--

--GLILRE F--NKKTNIPYSPMILALGLAVGLS-QEY--LGKIGNSAHILSKMHPHL--- --IVFIFIPVLLFESAFNCDWYTFKYQIINILLLAGPGCGWGAILLGA CFKL---VLQYGDEDMNWYEAFTLGSVLSAT--DPVAVVALLKE-LGA-NPAFNHL IEGEALLNDGVAMVLFNVFNNI--SKASSGKGE-A-VNGGDIILTFLR---TSFLG PIMGLILGLLVALWTRRILGDDVEVTWLTFVFTYFTFYWAEFE---FFKTSGLLAVVGLG LFWCAHAKTRIRASVE-HSVHAVWGFVQYSCDTLVFLLVGIIVGIEIMEEK- -LILTSDYYKMVGFYFLMILARLLMVLTFYPFLKCF--G-YPISKSELIVLVYGGL RGGLGLTLSLMVGCDEDLPARFRHLA-VFYAAAMALITNMINGTTCKTLVKC VKMIDEPIVKKKV-YKKYLEELIVIQQDLVKELETD---EFYN-MTDWAT-VNNLIG--Q QDFIEKIDKVEQE---IKH--LIQKRGFQEMIYEG- -LPNQEV-FGEVRY-R FYRILKGLYYHKYEEGLCEEQTVRMLVESSDVGLDKLSDNLEIWDELYKNF- -MN--LCSV--- -NFFFKVKQK--

-FLIGYFAREY-LIRHLGLVYDV- ---TSSFIICAEEA---LKLA-DNFPMNKEAI SIIQEEL---KKEIEKAQSYFG-TLNGSFPEIVRVLQTKKASFS ILT---HSIEHVQSTQRRGLIDDKE-YKILMKDINIKLVKLESH --SYD--- --MSLPSF HVIAMQFP---IF--QEISLSDLD-IIK KVAVERKYALGQVIYSKGSE-CNEVYIIMRGYVVNEYN--G-ILITKG LGSLITHQSLIVDGNHMSTA --KAAVESL-LYALPTKVIKEVMIRNKD--FEFKVYLHSIEYIRKWYENQVG PLAQMELKRLNELLRNKSRLVKLTTLSQIE--FINGGFLFSGELRDPKNNV--FNK YDY---IAPT-EGLF-TAAANSTCF--VFDEQ IE--

VLQSKRMKELKLDSQRDQEIHEKYSE-IKRNSVLELSKI- --NIT